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Background: Cell death induced by intracellutar glutathione depletion has been reported to be dependent on the presence of trace amounts of extracellular copper ions. Since little is known about the relationship between glutathione depletion and copper homeostasis, we have in the present study further investigated the role of low amounts of copper ions in glutathione depletion. Methods: Glutathion

OBJECTIVES: Our aim was to assess the reliability of nailfold capillary assessment in terms of image evaluability, image severity grade ('normal', 'early', 'active', 'late'), capillary density, capillary (apex) width, and presence of giant capillaries, and also to gain further insight into differences in these parameters between patients with systemic sclerosis (SSc), patients with primary Raynaud

X-ray absorption spectroscopy (XAS) includes well-established methods to study the local structure around the absorbing element - extended X-ray absorption fine structure (EXAFS), and the effective oxidation number or to quantitatively determine the speciation of an element in a complex matrix - X-ray absorption near-edge structure (XANES). The increased brilliance and intensities available at the

Substrate pH has been shown to be important for bryophyte distribution, although bryophytes are believed to obtain more or less all of their nutrients from rain water and deposition of airborn dust. In order to better understand bryophyte-pH relations we investigated pH ranges of bryophytes and bryophyte richness at different pH in southern Sweden. In addition, species turnover and critical pH val

Background: In many parts of the world, roadsides are regularly managed for traffic-safety reasons. Hence, there are similarities between roadsides and certain other managed habitats, such as wooded pastures and mown or grazed grasslands. In contrast to roadsides, the latter habitats have declined rapidly in Europe during the last century, and today only a fraction of their former extent remains.

Coastal erosion in Mozambique: Governing processes and remedial measures. Mozambique's 2800-km-long coastline comes with associated vulnerability to coastal erosion, their processes, and resulting evolution. In fact, coastal erosion has been identified as a dominant phenomenon in the Mozambican coastal system. It is driven by a combination of natural processes and anthropogenic actions. Despite th

Prostate cancer is the second most common diagnosed cancer among men. Currently there are no reliablebiomarkers to distinguish between indolent and aggressive disease. When men progress to advanced stages of the disease treatment options are limited and resistance to treatments available today is a growing problem. Recently the signal transducer and activator of transcription 3 (STAT3) has been su

Computed tomography (CT)-based finite element (FE) models may improve the current osteoporosis diagnostics and prediction of fracture risk by providing an estimate for femoral strength. However, the need for a CT scan, as opposed to the conventional use of dual-energy X-ray absorptiometry (DXA) for osteoporosis diagnostics, is considered a major obstacle. The 3D shape and bone mineral density (BMD

BackgroundPregnant women who gain excess weight are at risk of complications during pregnancy and in the long term. Interventions based on diet and physical activity minimise gestational weight gain with varied effect on clinical outcomes. The effect of interventions on varied groups of women based on body mass index, age, ethnicity, socioeconomic status, parity, and underlying medical conditions

BACKGROUND: Proliferative markers are not recommended as prognostic factors for clinical use in breast cancer due to lack of standardization in methodology. However, proliferation is driving several gene expression signatures emphasizing the need for a reliable proliferative marker for clinical use. Studies suggest that cyclin A is a prognostic marker with satisfying reproducibility. We investigat

The accuracy and precision of frameless neuronavigation as compared to conventional frame-based stereotaxy for implantation of deep brain stimulation (DBS) electrodes were studied in 14 patients with essential tremor. DBS electrodes were implanted bilaterally in the ventrolateral thalamus [ventrointermediate nucleus ( VIM)] in one procedure. Frameless neuronavigation was used on one side and the c

This work proposes methodologies using a model-based approach to gain knowledge on and assist the development of an ion-exchange step in a protein purification process; the separation of IgG from a mixture containing IgG, insulin and transferrin. This approach is suitable for capture and intermediate steps in a process. Both methods involve four consecutive steps. Firstly, the retention of the dif

Background The aim of this study was to investigate the prevalence of cerebral palsy (CP) as well as to characterize the CP population, its participation in a secondary prevention programme (CPUP) and to validate the CPUP database. Methods The study population was born 1990–1997 and resident in Skåne/Blekinge on Jan 1st 2002. Multiple sources were used. Irrespective of earlier diagnoses, neuropa

This work looks at three case studies from bog body research in Denmark, England and Ireland in order to investigate the variation of human decomposition in different depositional environments and the application of forensic methods to the area of bog body research in archaeology. The work attempts to assess the chosen case studies using an established forensic scoring method by Heaton et al (2010

Simulating vehicle scenarios for autonomous cars saves both time and money compared to physical testing. For this to work efficiently a sophisticated simulation software is often needed. Esmini is an open-source, lightweight vehicle simulator that can handle advanced traffic scenarios. When designing scenarios to be used for testing autonomous vehicles, it is often beneficial to set up relative ve

The thesis sheds light on the intersectional discrimination on basic education of the Rohingya refugee children in the Kutupalong unregistered camp of Cox’s Bazar in Bangladesh. The basic education for the refugee children is partly created through discriminatory means in the Rakhine state of Myanmar. It is further influenced by the limited education opportunities they are offered in the host coun

Uttrycket “övervakningssamhälle” är något som det talas om mer och mer. Vilket inte är så konstigt då många allmänna platser ofta är övervakade med antingen film eller ljudupptagning. Att kunna identifiera individer som på något sätt har brutit mot lagen eller förutse oönskade situationer är något som stärker vår säkerhet och ordningen i samhället. I många länder ses detta som helt nödvändigt och This report describes the product development process of a new product series of camera housings, adapted for modular applications. The purpose of the project was to develop a module containing a wiper, adapted for outdoor camera housings. The master thesis was performed at Axis Communications AB, a leading company in the surveillance camera industry. The camera housings of outdoor surveillance ca

The performance of five commercial available biobased packaging films for fully-baked frozen bread was studied in comparison to polyethylene (PE) film. The main purpose of this study was to understand how biobased packaging materials affect the quality of fully–baked frozen bread. The five biobased packaging films evaluated in this study were biobased polyethylene (bio-PE), Biodolomer®, polylactic

Populärvetenskaplig sammanfattning: Övergödningen av våra kustnära hav blev akut under 1980-talet, syrefria bottnar och giftiga algblomningar visade tydligt att något var mycket fel. Kväve, ett näringsämne, visade sig vara en av huvudorsakerna till dessa reaktioner i havet. De största kvävespridarna i Sverige var jordbruk och reningsverk. Avloppsvattenhanteringen behövde förändras och ett sätt attThe aim of this essay was to study the nitrogen flow in two willow plantations, at different locations in the south of Sweden, that were irrigated with sewage. The study was also performed to compare the differences in nitrogen flows between two years, 1998 and 1999. The study was made in three parts. First, the denitrification activity was measured using the acetylen inhibition method. Second the

The current curriculum requires a well functioning school library and an active use of it. In junior school grades 1-3 the children primarily learn basic skills. Knowledge about libraries and how to use them and different media is part of these skills. Therefore my intention was to investigate how school libraries in junior schools look, how they are used in the training and how they could be used