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Background: Outcomes for many cancer forms are associated with socioeconomic status (SES). We investigated if SES was associated with management and mortality in men with high risk prostate cancer. Material and methods: A nation-wide population-based cohort in Prostate Cancer Data Base Sweden (PCBaSe), a merged database including data on incident prostate cancer identified in the National Prostate

Nucleic acids are well recognized targets for platinum-based anticancer drugs, with RNA and DNA being kinetically comparable. In the case of RNA, previous studies have shown that the reaction between small duplex RNAs (dsRNAs) and monoaquated cisplatin (cis-Pt(NH3)2Cl(OH2)(+), ) can be followed by the metal induced hyperchromicity occurring directly after addition of to e.g. microRNA mimics. In th

Background: Weused a sensitive and specific beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) assay to determine the relationship between BACE1 activity in cerebrospinal fluid (CSF) and markers of APP metabolism and axonal degeneration in early and late stages of Alzheimer disease (AD). Objective: To assess CSF BACE1 activity in AD. Design: Case-control and longitudinal follow-up

Long-term eddy covariance measurements of energy and water fluxes and associated climatic parameters were carried out above a Scots pine (Pinus sylvestris) forest in the middle taiga zone of Central Siberia. Data from June 1998 through October 2000 are presented. With the exception of winter 1998/1999, data collection over this period were more or less continuous. A distinct seasonality in surface

Popular Abstract in Swedish Akupunktur är en mer än 2000 år gammal terapeutisk metod, som ingår i den traditionella kinesiska medicinen (TCM), för lindring av en del sjukdomar och symtom såsom smärta. Tunna, solida nålar instickes i så kallade akupunkturpunkter, oftast belägna i muskulaturen och utspridda över hela kroppen längs linjer som kallas meridianer. Det finns ett flertal olika sätt att teIn a retrospective follow-up study, n=202, long-term pain relief (>6 months) after a course of acupuncture treatments was found mainly among patients with chronic nociceptive pain while patients with neurogenic or psychogenic pain did not benefit much. In a placebo-controlled randomised single-blind long-term study with independent observer of chronic nociceptive low back pain, n=50, it was found

A recent statement from the European-Society-for-Sexual-Medicine has highlighted the limitations of using the rat model for nerve-sparing prostatectomy. The use of young rats with no comorbidities and the early evaluation of the erectile function (EF) are deemed a source of bias. Our aim was to evaluate the long-term consequences in EF of bilateral nerve cavernous crush- injury (BNCI) in type 1 di

The behavioural variant of frontotemporal dementia (bvFTD) is a frequent cause of early-onset dementia. The diagnosis of bvFTD remains challenging because of the limited accuracy of neuroimaging in the early disease stages and the absence of molecular biomarkers, and therefore relies predominantly on clinical assessment. BvFTD shows significant symptomatic overlap with non-degenerative primary psy

Individuals with chronic lymphocytic leukemia (CLL) face an increased risk for severe COVID-19. This study from Sweden, a country that only had a few mandatory restrictions at the onset of the pandemic, used 10 nationwide registers to compare the risks for severe COVID-19 outcomes of polymerase chain reaction-verified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections through

Alster som uppnått ett visst mått av individuell särprägel och originalitet skyddas i Sverige av upphovsrätt. Det upphovsrättsliga skyddet består av en ekonomisk och en ideell del. Vid fall av upphovsrättsintrång kan upphovsrättsinnehavaren väcka skadeståndstalan mot intrångsgöraren. När upphovsrättsintrång begås på internet sker intrången ofta i flera länder samtidigt utan att upphovsrättsinnehavWork that has achieved a certain degree of individual distinctiveness and originality is protected by the Copyright Act. Copyright protects both economic and moral rights. The copyright holder may bring an action for damages in cases of copyright infringement. In situations when the copyright infringement is committed on the internet, the infringement often occurs without the copyright holder know

Studien syftar till att ta fram rekommendationer och råd kring hur klimatpåverkan från anläggningsentreprenader kan beräknas och redovisas. Detta genom att undersöka hur andra aktörer inom branschen agerar i frågan och kartlägga modeller och verktyg för klimatberäkningar. Studien har utförts som en kombination av kvalitativa och kvantitativa forskningsmetoder, vilket kan liknas vid begreppet triaThe purpose of the study is to come up with recommendations and advice on how to calculate and present the climate impact from construction works. This will be implemented by examining how other actors within the construction industry is acting on the issue and examine models and tools for climate calculations. The study was conducted as a combination of qualitative and quantitative research meth

Alla svenska medborgare är garanterade yttrandefrihet gentemot det allmänna. Detta skydd återfinns i såväl svenska grundlagar som i de internationella konventioner som Sverige har antagit. Arbetstagare som har det offentliga som arbetsgivare åtnjuter en högre grad av skydd än de arbetstagare som är verksamma i den privata sektorn. Detta beror på att YGL samt TF är direkt tillämpliga gentemot dessaAll Swedish citizens are guaranteed freedom of speech against the State. This protection can be found in both the Swedish constitution and in international conventions which Sweden has adopted. Workers who are employed in the public sector enjoy a higher degree of protection than the workers employed in the private sector. This is because the Fundamental Law on Freedom of Expression and the Act on

As concentrations of measured CO2 in the atmosphere reach a record high it is important to attempt all possible efforts to reduce the emissions of greenhouse gases (GHG) in all aspects of industry. The fishing sector contributes 15% of total GHG emission in Iceland, with the majority originating from fishing vessels using fossil fuel. The relationship between catching locations of Atlantic Mackere

This study assesses the performance of buildings affected by climate change under future climate predictions for three time-periods until the end of the 21st century. Objects studied are residential multi-storey buildings, originally built before 1970 and retrofitted during the last decade. A total of four actual retrofit projects, as they were performed, in Denmark and Germany were assessed in th

Search and rescue operations can greatly benefit from the use of cooperative swarms of autonomous UAVs in order to investigate areas and collect information about the position of a missing person. In this thesis, UAV swarm algorithms are investigated where collisions are prevented both between agent pairs and between agents and static obstacles. The swarm consists of low-cost collaborative fixed-

På senare år har mängden produkter utrustade med sensorer och nätverks-funktioner ökat och fortsätter att öka. Dessa produkter, del av Sakernas Internet (IoT), möjliggör nya sätt för produkter avsedda för privat bruk att gå sönder och orsaka person- och sakskada. På EU nivå reglerar produktansvarsdirektivet (PLD) tillverkarens strikta ansvar för skador på andra produkter än den felande produkten sThe number of products equipped with sensor and network capabilities has risen in recent years and continues to increase. These products, part of the Internet of Things (IoT), bring about new ways for products intended for private use to malfunction and cause personal injury and property damage. In the EU, the Product Liability Directive (PLD) regulates producers’ strict liability for damage to ot

With the growing pool of deposited protein structures, the need for structural analysis tools grows. In study of amino acid substitutions the variety of analysis tools is high; nevertheless, there is a lack of programs serving specific purpose, such as identifying if an amino acid substitution would cause a clash in the structure or not, given just the structure of the original protein. In this stAnalysing structural damage caused by changes in proteins In an organism, even only one single change of an amino acid can sometimes lead to disease, if the protein is a part of an important biological function. Because of that, it is important to study those changes and be able to predict if an amino acid substitution would cause harm. There are various ways a substitution can be harmful to a pr

Human telomerase reverse transcriptase (hTERT) is a critical factor in unlimited cell proliferation and immortalization, with numerous studies demonstrating that high expression of hTERT is a poor prognostic factor in various types of cancer. Ubiquitin-conjugating enzyme E2D 3 (UBE2D3) is a member of the E2 family, and participates in the ubiquitin proteasome pathway to regulate basic cellular act

Packaging is one of the logistics areas where there often is potential and even a demand for improvements. An increase in environmental awareness among the population in the European Union (EU) has generated a demand for changes in packaging, which has led to stricter rules and regulations. Knowledge about what regulations are present and what may be expected in the future is crucial in the formin

BACKGROUND:: Exposure to second-hand smoke has been shown to be associated with increased cardiovascular mortality in several, but not all, epidemiologic studies. Our aim was to investigate the risk of circulatory death associated with exposure to second-hand smoke in never-smokers in a very large prospective study, the European Prospective Investigation into Cancer and Nutrition. A secondary aim