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The last decade has revealed hundreds of genetic variants associated with type 2 diabetes, many especially with insulin secretion. However, the evidence for their single or combined effect on beta-cell function relies mostly on genetic association of the variants or genetic risk scores with simple traits, and few have been functionally fully characterized even in cell or animal models. Translating
A reduced kinetic mechanism for methanol combustion at spark-ignition (SI) engine conditions is presented. The mechanism consists of 18 species and 55 irreversible reactions, small enough to be suitable for large eddy simulations (LES). The mechanism was reduced and optimized using the comprehensive mechanism (AramcoMech 2.0) as a starting point, to maintain performance at stoichiometric condition
Background: Recent years of research have increased the knowledge about how to support the transition to adulthood for youths with disabilities. In today’s multi-cultural societies knowledge about transitioning immigrant youths and their caregivers is still needed.Objective: To describe the expectations and needs of immigrant youths with disabilities residing in Sweden during their transition into
Precision nutrition is an emerging concept that aims to develop nutrition recommendations tailored to different people's circumstances and biological characteristics. Responses to dietary change and the resulting health outcomes from consuming different diets may vary significantly between people based on interactions between their genetic backgrounds, physiology, microbiome, underlying health sta
Microglial cells are brain-specific macrophages that swiftly react to disruptive events in the brain. Microglial activation leads to specific modifications, including proliferation, morphological changes, migration to the site of insult, and changes in gene expression profiles. A change in inflammatory status has been linked to many neurodegenerative diseases such as Parkinson's disease and Alzhei
BACKGROUND: Atypical antipsychotics have similar clinical efficacy in the treatment of schizophrenia; variability in their tolerability represents the discerning factor in treatment choices. Sertindole has a relatively good tolerability profile that favours long-term patient adherence and, therefore, is associated with lower rates of relapse and rehospitalization.AIM: A model was developed to comp
This is the software artifact for the paper "Efficient Demand Evaluation of Fixed-Point Attributes Using Static Analysis" published in SLE 2024.This artifact supports the evaluation of a new demand-driven algorithm for efficient circular Reference Attribute Grammar evaluation, specifically designed to improve performance of higly circular applications, e.g., dataflow analyses for Java. The artifac
The epoxide hydrolase StEH1 catalyzes the hydrolysis of trans-methylstyrene oxide to 1-phenyl-propane-1,2-diol. The (S,S)-epoxide is exclusively transformed into the (1R,2S)-diol, while hydrolysis of the (R,R)-epoxide results in a mixture of product enantiomers. In order to understand the differences in the stereoconfigurations of the products, the reactions were studied kinetically during both th
This project evaluates the impact of interior insulation on external walls in three Swedish heritage buildings. Field measurements and hygrothermal simulations were conducted to assess available solutions. Measurements of temperature and relative humidity were taken both indoors and outdoors, as well as on the exterior and interior surfaces of the walls. The accuracy of simulation standards for in
Hårdmetall är kompositmaterial av hårda volframkarbidkristaller i en seg koboltmatris. Det är ett användbart material, framförallt inom skärande bearbetning så som fräsning, borrning och svarvning, pga att segheten från kobolten kombineras med hårdheten från volframkarbiden. Man kan relatera hårdheten och segheten i hårdmetallen till dess mikrostruktur, där små karbidkristaller ger ett hårdare matThe grain growth of WC in WC-7%Co cemented carbides with Cr-addition was investigated for cemented carbides synthesized from four different raw materials varying in grain size. Cr additions were 4%of the Co binder phase. To investigate the effect of Cr on grain growth two of the raw materials were also synthesized without Cr-additions. To investigate the effect of cobalt content on grain growth ce
Varg har naturligt förekommit i hela landet genom historien men arten försvann nästan helt ur den svenska faunan under 1900-talet. Nu har vargen återigen etablerat sig i Sverige. Förutsättningarna för att förvalta varg genom jakt, så kallad licensjakt, är strikt begränsat. De bestämmelser som reglerar möjligheten till licensjakt på varg grundar sig på EU:s art- och habitatdirektiv, AHD. Dessa haWolves have occurred naturally across the country throughout history but disappeared almost completely from the Swedish fauna during the 20th century. Now the wolf has again established itself in Sweden. The prerequisites for managing wolves through hunting, known as licensed hunting, are strictly restricted. The provisions regulating the possibility to licensed hunting of wolves are based on the
Åderförkalkning - En undersökning av plackstabilitet Åderförkalkning, eller ateroskleros, är en kärlsjukdom som orsakar förträngningar i kroppens artärer. Hjärt- och kärlsjukdomar är de vanligaste orsakerna till dödsfall globalt - det uppskattas att 17,5 miljoner människor gick bort till följd av dem 2012, vilket motsvarar 31 % av alla dödsfall det året. Det saknas därmed inte anledningar till atAtherosclerosis is a chronic disease of arteries. Cardiovascular diseases, of which atherosclerosis is an underlying mechanism, are the most common causes of death globally. The disease is characterised by lipids having penetrated the intima of the artery wall, accompanied by inflammation, fibrosis and endothelial hyperplasia. Accumulated cells, lipids, connective-tissue elements and debris from t
Syftet med studien är att ta reda på vilka kunskaper som socialarbetare har när det gäller nära relationer med våld mot kvinnor med funktionshinder. Jag har gjort en kvalitativ studie med intervjuer, och jag har gjort fem intervjuer med socialarbetare från fyra kommuner i västra Sverige. När det gäller relationer med våld mot kvinnor med funktionshinder, har jag funnit olika typer av kunskap, somThe purpose of the study is to find out what experience the social workers have of violent relationships involving women with physical disabilities. I have done a qualitative study with interviews, and I have done five interviews with social workers from four municipalities in Western Sweden. I have tried to find out what the different types of knowledge are, and to what degree this knowledge is
En fastighetsaffär är för de allra flesta en stor affär, kanske den allra största man gör i sitt liv, och konsekvenserna kan därför också bli stora, både för köpare och säljare. En av frågeställningarna vid ett köp är ansvarsfördelningen mellan köpare och säljare och det finns många rättsfall genom åren där köparens undersökningsplikt vid köp av fast egendom prövas i svenska domstolar. Enligt JordA property transaction is for most people an important deal, and the impact can therefore also be great, both for buyers and sellers. One of the issues of a purchase is the division of responsibilities for errors between the buyer and the seller, and there are many court cases over the years where the buyer's duty to investigate the purchase of property is tried in Swedish courts. According to
One component in writing development is a more efficient use of syntactic tools. Later syntactic development, specifically that of the noun phrase, is an understudied area, notably so for Swedish. The demand for specified and concise information in an expository text, and the availability of more planning time in the written modality, are important factors contributing to more complex noun phrases
Gold is known in the financial world to be an important asset in unstable periods, especially as a hedge against inflation. If the gold price can be forecasted, it will be possible to strategically invest in gold rather than acquire it as a last-minute hedge against economic downturns. Although there are many studies on forecasting, few focus directly on gold returns. This study investigates the
Orkanen i Malmö är en universitetsbyggnad som består av fem tillgängliga våningsplan och ett källarplan. Det finns även våning sex och sju, de är dock inte är tillgängliga för studenter eller allmänheten. Genom platsbesök, tillgänglig litteratur kopplat till anläggningen och genom en kontaktperson utvärderas brandskyddet i Orkanen ur ett personsäkerhets perspektiv. Utvärderingen sker genom att möjThe purpose of this report is to evaluate the fire safety of the university building Orkanen Malmö as an educational part of the course Fire Risk Assessment (VBRN70) at Lund University (LTH). Limited to the safety of occupants in the building, the report does not take economic or structural damage into account. To begin with, the building was investigated during a guided tour where photographs wer
