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OBJECTIVE: Lung transplantation is hampered by the lack of organs resulting in deaths on the waiting list. The usage of donation after circulatory death (DCD) lungs would dramatically increase donor availability. The most optimal organ preservation method, and the need for antithrombotic and fibrinolytic treatment to prevent thrombosis in the donor lungs is currently on debate. The present study i
It has been acknowledged that the traditional didactic lecture does not always provide the ideal learning and teaching experience (Bligh, 1998). Over the last ten years, individuals and institutions have been exploring the pedagogical possibilities of providing more active and engaging alternatives. One model in particular has been influential in sparking change. The use of Active Learning Spaces
Strengthening of feed security in the Sahel is urgently needed given the climate change and growing human population. A prerequisite to this is sustainable use of rangeland forage resources for livestock. Many studies have focused on the assessment of rangeland resources during the rainy season, while only a few have focused on the dry season which is the longest and most demanding period for live
Background: Very preterm infants are at high risk of developing chronic lung disease, which requires respiratory support and might have long-term sequelae. As lung inflammation plays an important role in pathogenesis, antileukotrienes have been explored in both clinical and animal studies. We aimed to assess the benefits and harms of antileukotrienes for the prevention and treatment of respiratory
Aims/hypothesis: The aim of this study was to determine whether BMI in early childhood was affected by the COVID-19 pandemic and containment measures, and whether it was associated with the risk for islet autoimmunity. Methods: Between February 2018 and May 2023, data on BMI and islet autoimmunity were collected from 1050 children enrolled in the Primary Oral Insulin Trial, aged from 4.0 months to
Popular Abstract in Swedish Kritiskt sjuka patienter på intensivvårdsavdelningar (IVA) har ofta störningar i blodets levringsförmåga (koagulation). Kliniska tecken som blodpropp (djup ventrombos eller blodpropp i lungorna) och/eller blödning kan vara resultatet av aktivering och konsumtion av koagulationsfaktorer och koagulationshämmare. Disseminerad intravaskulär koagulation (DIC, som är en samtiCritically ill patients in intensive care units (ICU) often have coagulation disturbances. Clinical manifestations such as thromboembolism and/or bleeding may result from activation and consumption of coagulation factors and inhibitors. Disseminated intravascular coagulation (DIC) is a severe condition with an often-poor prognosis. Global haemostatic tests are inexpensive, widely available, and ma
The management of primary gastrointestinal stromal tumours (GISTs) has evolved with the introduction of adjuvant therapy. Recently reported results of the SSG XVIII/AIO trial by the Scandinavian Sarcoma Group (SSG) and the German Working Group on Medical Oncology (AIO) represent a significant change in the evidence for adjuvant therapy duration. The objectives of this European Expert Panel meeting
Popular Abstract in Swedish Det svenska samhället har under senare delen av 1900-talet påverkats och förändrats på grund av en ökad internationell migration. År 1950 var 2,8 % av den svenska befolkningen utrikesfödd; idag utgör de utrikesfödda 12,0 % av totalbefolkningen. Om även andragenerationens migranter (de som har en eller båda föräldrar utrikesfödda) räknas med utgör första och andrageneratAims: The general aim of this thesis was to describe and compare the group of foreign-born persons living in Sweden and native Swedes with regard to health development over time, thus studying the influence of migration on health. Methods: All four studies are based on data from Statistics Sweden (SCB) and the National Board of Health and Welfare, Centre for Epidemiology covering the period 1970?
Popular Abstract in Swedish Järn har den kemiska beteckningen Fe från latinskans ferrum. Det är det fjärde vanligaste ämnet i världen och utgör ca en femtedel av jordskorpan. Trots det kan både djur och växter ha järnbrist. Hur kan detta vara möjligt? Problemet är egentligen inte förekomsten av järn utan att järnet som vi och alla andra organismer behöver har oxidationstillståndet Fe(II) medan detIt is of vital importance to understand the systems for iron metabolism and this thesis contributes to this by providing insights into the structure and function of the acquisition and homeostasis of iron. The two proteins that have been primarily investigated are a ferric reductase from Arabidopsis thaliana called FRO2 and a mitochondrial iron chaperone from Saccharomyces cerevisiae called fratax
Popular Abstract in Swedish Fjärrvärme är ett centraliserat uppvärmningssystem där varmt vatten distribueras i ett rörnätverk och används främst till byggnadsuppvärmning och för att värma varmvatten. Fjärrvärme finns i alla länder på norra halvklotet men har störst marknadsandel i Norden och Baltikum. I Sverige används fjärrvärme för att värma c:a 60% av all byggnadsyta. Två stora fördelar med fjäRenewable energy sources dominated the world energy supply until the beginning of the 20th century, when fossil energy became the dominant energy source worldwide. Today, fossil fuels contribute to over 80% of world energy supply. But there are two major reasons why fossil energy use has to stop. First, fossil energy is limited and will not last forever. Second, emissions of carbon dioxide change
OBJECTIVES: To determine whether CA 125 measurement is superior to ultrasound imaging performed by an experienced examiner for discriminating between benign and malignant adnexal lesions, and to determine whether adding CA 125 to ultrasound examination improves diagnostic performance. METHODS: This is a prospective multicenter study (International Ovarian Tumor Analysis (IOTA) study) conducted in
The dust detector system on board the Galileo spacecraft recorded dust impacts in circumjovian space during the craft's orbital mission about Jupiter. This is the eighth in a series of papers dedicated to presenting Galileo and Ulysses dust data. We present data from the Galileo dust instrument for the period January 1997-December 1999 when the spacecraft completed 21 revolutions about Jupiter. In
Diet is considered one of the key factors contributing to an increased risk of developing diabetes type 2. The rising prevalence of this condition is alarming and highlights the urgent need for effective nutrition-based strategies to alleviate an impending health crisis. As reoccurring hyperglycaemic episodes have been linked to an increased risk of becoming a diabetic, there is an opportunity for
Översiktliga beräkningar visar att ca 2 miljoner människor utsätts för trafikbullernivåer överstigande de riktvärden som riksdagen ställt sig bakom. Ungefär 500 000 av dessa utsätts för buller från tågtrafiken. Trafikbuller har betydelse för vår hälsa och de negativa effekterna kan vara störning av dagliga aktiviteter, stress sömnsvårigheter, koncentrationsproblem och högt blodtryck. Detta arbete Roughly 2 million Swedish citizens are exposed to traffic noise from roads, railways and aircrafts at levels higher than those approved by the government. As many as 500 000 of these are subject to railway noise. Exposure to traffic noise can have negative effects and cause irritation and disturbance of daily activities and also create general health problems such as lack of sleep, stress, concent
Populärvetenskaplig sammanfattning: Examensarbetet har gått ut på att med hjälp av satellitbilder göra markanvändningsdata för att förbättra en modell som beräknar vart de luftburna föroreningarna tar vägen. Föroreningarna svavel och kväve deponeras med olika hastighet över olika marktyper, därför vill man använda sig av markanvändningsdata i modellerna. Svavelutsläppen har ökat dramatiskt under Sulphur emissions during the last century has led to major acidification of the environment. The acidity of soil and water is a threat to health and economic interests of man, e.g. the food and paper/wood production in the agricultural and silvicultural industries. The Black Triangle region suffers from severe damage caused by acidification and actions to decrease the acid rain over fields and for
Oatly is a company that produces and sells oat based products. Their most selling product is the oat drink, which is a substitute to milk, and over 80 percent of the annual sales volume comes from this product. Since the foundation of Oatly, the main idea has been to sell their products on markets with low milk availability and milk consumption. Most recently, Oatly identified the Chinese market a
Background: Clinical trial participants may be temporarily absent or withdraw from trials, leading to missing data. In intention-to-treat (ITT) analyses, several approaches are used for handling the missing information - complete case (CC) analysis, mixed-effects model (MM) analysis, last observation carried forward (LOCF) and multiple imputation (MI). This report discusses the consequences of app
Popular Abstract in Swedish Prostatacancer är en av de vanligaste förekommande cancerformerna. Många äldre män har cancerceller i sin prostata, men som tur är behöver inte all cancer behandlas eftersom den inte växer. I USA får ungefär 27% av alla män prostatacancer och cirka 10% dör av det. Vi har utvecklat en ny miniatyriserad metod för att påvisa prostatacancer (Paper I). Genom att titta på PSAThe aim of this thesis is development and application of different miniaturized strategies for detection of biomarkers. The biomarker PSA (prostate specific antigen), which is prostate cancer specific, has been the main focus of the thesis. The papers present two miniaturized strategies for biomarker detection, developed at the department, an antibody microarray and the ISET platform. The antibo
The relationship between ancient hominins and modern humans, from a new perspective Many questions followed the discovery and identification of the Neanderthal from the fossil record in 1856 as to its place in the hominin tree and its relationship with modern humans. Was it a direct ancestor? A remote cousin? Or did it mix with humans? Once reliable nuclear DNA data became available in 2010, the
