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Psychotropic pharmaceuticals present in the environment may impact organisms both directly and via interaction strengths with other organisms, including predators; therefore, this study examined the potential effects of pharmaceuticals on behavioral responses of fish to avian predators. Wild-caught juvenile perch (Perca fluviatilis) were assayed using a striking bird model after a seven-day exposu
Since 1978, China has experienced a series of economic reforms, transitioning from a centrally planned economy to a liberal market economy. Correspondingly, the economic transformation has left a profound impact on the health care system. Universal free health care provided by state-owned enterprises was gradually replaced by modern social medical insurance schemes. The government dramatically dec
In the newly founded state Kosovo, the women’s rights movement has become a strong voice on gender equality and contributes in important ways to strengthening women’s rights. At the same time, highly gendered political structures restrict the movement’s access to political influence. The purpose of this thesis is to explore how the political opportunities and challenges that the movement faces hav
Isla de los Estados (54A degrees 45'S, 63A degrees 10'aEuro"64A degrees 46'W) lies east of the main island of Tierra del Fuego and is the southeastern-most point in Argentina. Because of its geographic position near the latitudes of the Southern Hemisphere Westerlies and the strong influence of the Antarctic Circumpolar Current (ACC), the area is suitable for paleoecological and paleoclimate resea
BACKGROUND: The mechanism behind the antiviral action of interferon (IFN) therapy in chronic hepatitis C virus (HCV) infection is not well understood, and, furthermore, few factors have been shown to be good predictors of a favourable response to IFN treatment in chronic HCV infection. METHODS: Freshly explanted liver cells and peripheral blood mononuclear cells (PBMC) from 80 patients with chroni
Background: Saturated fat (SFA) has consistently been shown to increase liver fat, but the response appears variable at the individual level. Phenotypic and genotypic characteristics have been demonstrated to modify the hypercholesterolemic effect of SFA but it is unclear which characteristics that predict liver fat accumulation in response to a hypercaloric diet high in SFA. Objective: To identif
Introduction: Immune checkpoint inhibitors (ICIs) have transformed lung cancer treatment, yet their effectiveness seem restricted to certain patient subsets. Current clinical stratification on the basis of programmed death ligand 1 (PD-L1) expression offers limited predictive value. Given the mechanism of action, directly detecting spatial programmed cell death protein 1 (PD1)–PD-L1 interactions m
Cell culturing methods are increasingly used to reduce and replace the use of live animals in biomedical research and chemical toxicity testing. Although live animals are avoided when using cell culturing methods, they often contain animal-derived components of which one of the most commonly used is foetal bovine serum (FBS). FBS is added to cell culture media among other supplements to support ce
The aim of this masters dissertation is to investigate how problems that includes fluids can be solved numerical through FE-analysis. The problem at hand is to predict the impact force implied by breaking ocean waves on vertical coastal structures. The importance that coastal areas has on human society both from a perspective of economy, infrastructure and recreation are indubitable. Furthermore,
Glucostatic appetite regulation has numerous determinants, among others: cephalic phase digestion, gastric emptying and absorption, together influencing postprandial blood glucose responses and satiety. This short communication presents and reviews studies of gastric emptying, antral distension and postprandial glucose response and their relation to reports of satiety in healthy non-obese over nig
Popular Abstract in Swedish I den här avhandlingen studeras problem från två områden, medicin och kommunikation. Den medicinska delen behandlar skattning av Händelserelaterade signaler (Event-related Potentials, ERP). Dessa signal uppkomer i hjärnan då försökspersonen stimuleras via yttre påverkan, t.ex ljusblinkning, pipljud eller elektrisk stimulering av huden. De händelserelaterade signalerna kThis thesis consists of five parts in which problems in two fields, medical and telecommunication, have been studied. In the first part, a prediction algorithm, the Prony method, for estimation of frequencies and damping factors of sinusiods is developed for a coloured noise disturbance. The method is applied to estimating a single Event-Related Potential, sERP, and the estimation principle is ev
Objective To investigate the 2-year clinical and radiological outcomes of patients with early rheumatoid arthritis (RA; symptom duration <1 year) who had initially responded well to methotrexate monotherapy. Methods In the SWEFOT trial, all 487 patients started methotrexate (target dose 20 mg/week). After 3-4 months, 147 had low disease activity, 28-joint based disease activity score (DAS28) <= 3.
Objectives: Antithymocyte globulin (ATG)-based immunosuppression remains a cornerstone in aplastic anaemia (AA) treatment. However, most ATG studies are not population-based and knowledge about real-world results concerning response and outcome could offer important information for treating physicians. Methods: We have recently performed a nationwide retrospective cohort study on all AA patients d
Injectable Bioresorbable Organic Bioelectronics Neuropharmacology—our ambition is to supplement classical biochemical signaling with the modulation of bioelectricity using both ionic and electronic processes. We focus on organic electronics that self-assemble directly inside or near the nervous system to form electronic circuits that mimic its structure and organization, enabling seamless integrat
