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BACKGROUND: Osteopenia, osteoporosis, and low bone mineral density are frequent in patients with HIV. We assessed the 96 week loss of bone mineral density associated with a nucleoside or nucleotide reverse transcriptase inhibitor (NtRTI)-sparing regimen.METHODS: Antiretroviral-naive adults with HIV were enrolled in 78 clinical sites in 15 European countries into a randomised (1:1), open-label, non
The present review discusses two types of biological rhythms, namely, circadian rhythms and circannual rhythms. Humans possess a circadian rhythm of approximately 24 hours, which is regulated by neural and hormonal processes. The synchronisation of this rhythm with the solar day and night is maintained through entrainment mainly by light. Dark environments completely lacking windows may have a neg
BACKGROUND: Cyclin A1 is a cell cycle regulator that has been implicated in the progression of prostate cancer. Its role in invasion and metastasis of this disease has not been characterized. METHODS: Immunohistochemistry and cDNA microarray analyses were used to assess protein and mRNA expression of cyclin A1 and proteins with roles in metastasis, including vascular endothelial growth factor (VEG
IMPORTANCE: The clinical utility of stress cardiovascular magnetic resonance imaging (CMR) in stable chest pain is still debated, and the low-risk period for adverse cardiovascular (CV) events after a negative test result is unknown.OBJECTIVE: To provide contemporary quantitative data synthesis of the diagnostic accuracy and prognostic value of stress CMR in stable chest pain.DATA SOURCES: PubMed
An important part of Sweden’s first freedom of religion act, passed in 1951, was citizens’ right not to practice a religion. The post-World War II generations lived in an increasingly secularized paradigm. In this context, Göran Göransson was a very knowledgeable and influential jurist who not only practiced ecclesiastical law within the Swedish church but also served as a departmental jurist acti
Laminar burning velocity of lean methane/air flames exposed to pulsed microwave irradiation is determined experimentally as part of an effort to accurately quantify the enhancement resulting from exposure of the flame to pulsed microwaves. The experimental setup consists of a heat flux burner mounted in a microwave cavity, where the microwave has an average power of up to 250 W at an E-field in th
The contributions from anions and cations from salt are inseparable in their perturbation of molecular systems by experimental and computational methods, rendering it difficult to dissect the effects exerted by the anions and cations individually. Here we investigate the solvation of a small molecule, caffeine, and its perturbation by monovalent salts from various parts of the Hofmeister series. U
Understanding of the Schottky barriers formed at metal contact-InAs nanowire interfaces is of great importance for the development of high-performance InAs nanowire nanoelectronic and quantum devices. Here, we report a systematical study of InAs nanowire field-effect transistors (FETs) and the Schottky barrier heights formed at the contact-nanowire interfaces. The InAs nanowires employed are grown
Ancient genomes provide a tool to investigate the genetic basis of adaptations in extinct organisms. However, the identification of species-specific fixed genetic variants requires the analysis of genomes from multiple individuals. Moreover, the long-term scale of adaptive evolution coupled with the short-term nature of traditional time series data has made it difficult to assess when different ad
Mutualism, interspecific cooperation that yields reciprocal benefits, can promote species coexistence, enhancing biodiversity. As a specific form of mutualism, cross-feeding, where each of two mutualists produces a resource the other one needs, has been broadly studied. However, few theoretical studies have examined competition between cross-feeding mutualists and cheaters, who do not synthesize r
The International Human Papillomavirus (HPV) Reference Center launches annual global HPV genotyping proficiency panels to enhance the precision and international standardization of HPV genotyping services. This study aims to assess the proficiency levels achieved in the global HPV genotyping proficiency panels conducted in 2022 and 2023, and to evaluate trends in performance over time. The profici
Aim: Public health nurses working in high schools have few set tasks, and there is limited research available on their flexible role. Therefore, the aim of the study was to describe public health nurses’ perspectives on their role when working in Norwegian high schools. Design: A qualitative descriptive design, with an inductive approach. Sample: Eight public health nurses with at least 1-year of
Foreign aid for media development has often been associated with the promotion of specific models or ideals for journalism. Efforts by national aid agencies, NGOs, UNESCO, and media organisations have aimed to support journalists worldwide. However, due to limitations in financial sustainability, inadequate media structures, and competing journalistic ideologies in recipient countries, the impact
Parkinson's disease (PD) is characterized by the loss of the dopaminergic nigrostriatal pathway which has led to the successful development of drug therapies that replace or stimulate this network pharmacologically. Although these drugs work well in the early stages of the disease, over time they produce side effects along with less consistent clinical benefits to the person with Parkinson's (PwP)
The IntCal family of radiocarbon (14C) calibration curves is based on research spanning more than three decades. The IntCal group have collated the 14C and calendar age data (mostly derived from primary publications with other types of data and meta-data) and, since 2010, made them available for other sorts of analysis through an open-access database. This has ensured transparency in terms of the
With biobased buildings making the transition into mainstream construction, the safety of their occupants needs to be adequately ensured, since the introduction of combustible building materials is bearing fundamental ramifications for fire safety strategies of such buildings. The present work introduces a research project on safe evacuation of timber buildings. More specifically, it targets to in
Taking its cue from questions raised in ecocritical theory, this article studies some of the central themes in the poetry of Swedish ALMA laureate Barbro Lindgren: the non-hierarchical attitude towards all that lives and exists; the cycle of life and death that is a fundamental condition of existence for human and non-human animals as well as for trees and plants; and the exploration of scales tha
As climate has warmed significantly over past decades, numerous studies have confirmed a pattern of more frequent and more intense hydro-climate events across the globe, such as floods, heatwaves, and droughts. Analyzing the variability of climate events with reliable historical data records is one of the most direct approaches for understanding its patterns of change. The development of climate m
