Filetype
Purpose - The employment of continuous ribs in a passage involves a noticeable pressure drop penalty, while other studies have shown that truncated ribs may provide a potential to reduce the pressure drop while keeping a significant heat transfer enhancement. The purpose of this paper is to perform computer-aided simulations of turbulent flow and heat transfer of a rectangular cooling passage with
Objective Zinc transporter 8 autoantibodies (ZnT8A) have been poorly studied in non-Caucasian individuals. We aimed to investigate the prevalence of ZnT8 autoantibodies in patients with T1D and their first degree relatives (FDR) from a multiethnic population, as well as its relation with the insulin (INS) or the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene polymorphisms. Subjects and
Haemophilus influenzae is a Gram-negative human pathogen that resides in the upper respiratory tract. Encapsulated H. influenzae type b (Hib) and type f (Hif) are the most common serotypes associated with invasive disease. H. influenzae displays various strategies to circumvent the host innate immune response, including the bactericidal effect of the complement system. In this study, we identified
Body fatness has been associated with increased risk of a number of hormone-dependent cancers. Recent studies suggest that body mass index (BMI) may be related to meningiomas, which are more common in women than men, and for which estrogens are believed to play a role. Using data from a large European propective cohort, 203 incident cases of meningioma and 340 cases of glioma were included in the
To assess the reproducibility of 3D delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 3 T in early stage knee osteoarthritis (OA) patients. In 20 patients, 3D dGEMRIC at 3 T was acquired twice within 7 days. To correct for patient motion during acquisition, all images were rigidly registered in 3D. Eight anatomical cartilage ROIs were analysed on both images of each patient. Capability of
Collateral damage caused by extracellular histones has an immediate impact on morbidity and mortality in many disease models. A significant increase in the levels of extracellular histones is seen in critically ill patients with trauma and sepsis. We showed that histones are released from necrotic cells in patients with invasive skin infections. Under in vitro conditions, endogenous p33, an endoth
The European hummingbird hawkmoth Macroglossum stellatarum is a diurnal nectar forager like the honeybee, and we expect similarities in their sensory ecology. Using behavioural tests and electroretinograms (ERGs), we studied the spectral sensitivity of M. stellatarum. By measuring ERGs in the dark-adapted eye and after adaptation to green light, we determined that M. stellatarum has ultraviolet (U
Both environmental and genetic factors can dramatically affect reproductive performance in mice. In this study we have focused on the identification of genetic regions, quantitative trait loci (QTL), which affect the breeding capacity of female mice. We have identified polymorphic microsatellite markers for the mouse strains used and performed a genomewide scan on 237 females from a gene-segregati
The history of von Willebrand's disease (VWD) is fascinating because it demonstrates how good clinical observations, genetic studies and biochemical skills can improve basic understanding of a disease and its management. The continuous efforts of scientists and clinicians during the last 80 years have significantly improved the knowledge of von Willebrand factor (VWF) structure and function and th
Mutations in the BRAF oncogene occur in the majority of melanomas, leading to the activation of the mitogen-activated protein kinase pathway and the transcription of downstream effectors. As BRAF and its effectors could be good melanoma therapy targets, defining the repertoire of genes that are differentially regulated because of BRAF mutational activation is an important objective. Towards this g
Background: A DGGE-based assay for hepatitis B virus (HBV) drug-resistance monitoring was designed and checked for feasibility. It detects mutations within the YMDD motif related to lamivudine resistance. Material/Methods: The YMDD motif of HBV polymerase was amplified by the set of primers designed in this study. DGGE analysis of the amplicons was performed on 9% polyacrylamide gels containing a
OBJECTIVE: Periodontal ligament (PDL) cells express oestrogen receptor beta (ERbeta) protein, but cellular functions regulated by ERbeta in these cells have not been identified. In this study we determine if ERbeta is localised to mitochondria and if oestrogen regulates mitochondrial function in human PDL cells obtained from teeth extracted for orthodontic reasons. DESIGN: Subcellular distribution
We recently presented a new method for quantification of CArdiac FUnction - denoted CAFU - as the first step in the development of an automated method for integrated interpretation of gated myocardial perfusion single photon emission computed tomography (SPECT) images. The aim of this study was to validate CAFU in the assessment of global and regional function of the left ventricle. Quantitative g
The calcitonin gene-related peptide (CGRP) is a 37 residue neuropeptide which causes vasodilatation, increases heart rate and inhibits bone resorption. These effects make it an interesting lead for drug discovery. We have combined current structural and biological information to model the structure of hCGRP-beta to be used as a basis for the rational design of novel analogues. Distinct regions of
Prevention of incorporation of dUTP into DNA is essential for maintenance of the genetic information. Prompt and specific removal of dUTP from the nucleotide pool, as expedited by the ubiquitous enzyme dUTPase, is therefore required for full viability in most biological systems. Conserved structural features perpetuate specificity in choice of substrate, which is crucial as hydrolysis of the struc
In recent years, the growing scientific interest in design has led to great advances in our knowledge of authentic design processes. However, as these findings go counter to the existing theories in both design research and cognitive science, they pose a serious challenge for both disciplines: there is a wide gap between what the existing theories predict and what designers actually do. At the sa
Popular Abstract in Swedish Avhandlingens bidrag ligger inom området för Markov regimskiftesmodeller i tidsserieanalys. Den består av fem separata uppsatser som specifikt undersöker två statistiska frågeställningar, samt applicerar metodologin på fyra olika makroekonomiska områden. De två huvudsakliga statistiska bidragen rör (i) utvecklandet av ett flexibelt test baserat på simulering för att utrThis dissertation studies statistical properties and applications of the Markov switching models for economic time series in five separate papers. The two main statistical themes are (i) the task of choosing the number of states to use in the model, and (ii) inference on time-varying transition probabilities. Our empirical applications span a wide array of topics in international finance and macro
Popular AbstractStudier om undomars arbetsmotivation och inställning till arbete fokuserar ofta på skolundomar, vilket kan ge idealiserade bilder eftersom dessa ungdomar ännu inte försökt ta sig in på arbetsmarknaden. Verica Stojanovics avhandling fokuserar emellertid på ”äldre” (20-29 åriga) svenska och danska ungdomar som varit arbetslösa i några månader eller mer och hunnit känna av hur det är My aim is to show how unemployed youth, in Sweden and Denmark, during the years 1992-1996, were coping with their situation as unemployed, by focusing on their motivation for work, their conception of work, and their alternative action. Swedish youth have for a number of decades lived with a labour market policy which has had full employment as a goal and included active measures. Danish youth hav
A "complex salt" of cetyltrimethylammonium (CTA(+)) with short (30 repeating units) polyacrylate (PA(-)) counterions has been synthesized. The phase diagrams of its aqueous mixtures with either the surfactant cetyltrimethylammonium acetate (CTAAc), or the polyelectrolyte NaPA, have been studied by visual inspection through crossed polarizers and by small-angle X-ray scattering. Both of the ternary
Treatment of [Os-3(mu-H)(2)(CO)(10)] with the chiral diphosphines BINAP, tolBINAP [(R)-2,2'-bis(di-4-tolylphosphino)-1,1'-binaphthyl], DIOP [(4R,5R)-(-)-O-isopropenylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino) butane] affords [Os-3(mu-H)(2)(CO)(8)(mu-L)] (L = BINAP (1), tolBINAP (2), DIOP (4)) in high yield. The X-ray structures for 1, 2 and 4 are reported, and structural and spectroscopic comp
