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Microglia manage immunosurveillance and mediate inflammation, both suggested to be important in Alzheimer's disease (AD). The aim of this study was to investigate if microglial markers could differentiate, firstly between AD and controls, and secondly between stable mild cognitive impairment (MCI) and those progressing to AD and vascular dementia (VaD). Furthermore, we investigated if these marker
BACKGROUND: Progressive immune dysfunction and the acquired immunodeficiency syndrome (AIDS) develop in most persons with untreated infection with human immunodeficiency virus type 1 (HIV-1) but in only approximately 20 to 30% of persons infected with HIV type 2 (HIV-2); among persons infected with both types, the natural history of disease progression is poorly understood. METHODS: We analyzed d
The economic output of the dairy industry is to a great extent dependent on the processing of milk into other milk-based products such as cheese. The yield and quality of cheese are dependent on both the composition and technological properties of milk. The objective of this study was to evaluate the importance and effects of casein (CN) micelle size and milk composition on milk gelation character
The thesis aims to explore subjective experiences of everyday occupation, social interaction and the view of the worker role among people with psychiatric disabilities(PD), while also addressing the importance of day centre attendance. The thesis consists of one qualitative study, exploring which characteristics in everyday occupation provide meaning to people with PD, and three quantitative studi
Popular Abstract in Swedish Den här avhandlingen handlar om hur kristaller, som innehåller en liten mängd av ämnen tillhörande gruppen sällsynta jordartsmetaller, kan användas för forskning och tillämpningar rörande kvantinformation. Genom att belysa kristallerna med laserljus kan atomernas tillstånd styras och studeras. I avhandlingen diskuteras olika aspekter av hur de sällsynta jordartsatomer sThis thesis describes investigations of the use of cryogenically cooled rare-earth-ion-doped crystals for quantum information processing and quantum optics. Several aspects of the coherent interaction between light and rare-earth ions in solids are addressed. Quantum information science has given physicists new views of quantum mechanics. The transmission of quantum states has already found pract
A new type of supermacroporous, monolithic, cryogel affinity adsorbent was developed, allowing the specific capture of urokinase from conditioned media of human fibrosarcoma cell line HT1080. The affinity adsorbent was designed with the objective of using it as a capture column in an integrated perfusion/protein separation bioreactor setup. A comparative study between the utility of this novel cry
Objective: The concentration of the complex between activated protein C (APC) and protein C inhibitor (PCI) is a measure of thrombin generation. We studied whether it can provide information useful for the diagnosis and treatment of arterial vascular disease. Methods: Blood was obtained from 429 vascular patients admitted consecutively during September 2004 to March 2005. The APC-PCI complex was m
The neuropeptide vasoactive intestinal polypeptide (VIP), which is found in a population of cholinergic parasympathetic neurons in the airways, has no effects per se on mucociliary activity. In order to test the hypothesis that VIP may modulate cholinergic regulation of the mucociliary system, VIP was infused intraarterially (8.4 pmol/kg/min), and the response to challenges with methacholine in th
BACKGROUND: There is an increasing interest in cognitive and functional outcomes in the respective stages of Alzheimer's disease (AD) and in novel therapies particularly for the milder phases of AD. Our aim was to describe and compare various aspects of disease progression in patients with mild versus moderate AD in routine clinical practice of cholinesterase inhibitor (ChEI) therapy. METHODS: Thi
Chronic obstructive pulmonary disease (COPD) independently associates with an increased risk of coronary artery disease (CAD), but it has not been fully investigated whether this co-morbidity involves shared pathophysiological mechanisms. To identify potential common pathways across the two diseases, we tested all recently published single nucleotide polymorphisms (SNPs) associated with human lung
To better understand and predict the combustion behavior of methanol in engines, sound knowledge of the effect of the pressure, unburned mixture temperature, and composition on the laminar burning velocity is required. Because many of the existing experimental data for this property are compromised by the effects of flame stretch and instabilities, this study was aimed at obtaining new, accurate d
Popular Abstract in Swedish Lars Ahlin har en central position i den svenska litteraturen. I forskningen framträder bilden av hans författarskap som ett litterärt projekt präglat av en jämlikhetsvision, ett motstånd mot språkliga, existentiella och politiska hierarkier. Det ahlinska berättandet är ett sällsynt gott exempel på hur ett litterärt projekt också kan vara etiskt bestämt. Detta samband bAs my title indicates, this dissertation is oriented towards two academic subjects: Ethics and Literature. Of late, the borderland between these two disciplines has attracted international scholarly attention. Within ethics, literary works are becoming a primary material; conversely, the study of literature has taken on ethical issues. As a result, the potentially referential character of fiction
Popular Abstract in Swedish Förebyggande av hjärtkärlsjukdom har varit en utmaning för medicinsk forskning under flera decennier. Viktiga frågeställningar om såväl screeningmetodik som risk-faktor intervention söker fortfarande sitt svar och har i sig betydelse för både samhällsmedicin och klinisk verksamhet. Målsättningen för denna studie var att undersöka möjligheten för läkare och sjuksköterskoCardiovascular disease prevention has been a challenge for research for decades. The studies of this thesis were designed to investigate the role of health professionals in everyday clinical work based upon the concept of comprehensive primary care consultation. Routine check-up of blood pressure was the basis for the inclusion in an opportunistic screening for hyperchol-esterolaemia. Additionally
This article is based on a study of the sailing event America’s Cup in Malmö in the late summer of 2005. It serves the purpose of exemplifying a project of urban governance. Urban governance means that municipalities are engaged in implementing different strategies in order to strengthen their own position in the competition between cities and regions. The article’s main theme is the relation betw
The lichen flora of the Nordic countries, containing about 2,000 species, is regarded as one of the best known in the world. Lichenological research of the region has been continuous since the time of Erik Acharius (1757-1819), the 'father of lichenology', but there is no modern treatment of the region's impressive lichen flora. The last attempt was made in the 1870s by Th. M. Fries, but his major
Structural investigations of compounds in the CsI-(Cd/Hg)I2 system have been performed by means of X-ray diffraction, thermogravimetric and calorimetric techniques. Crystals of the compounds studied were synthesized from aqueous solutions of CsI and CdI2/HgI2 by the slow evaporation of water. In total, the structure of ten compounds were determined by means of X-ray diffraction on single crystals,
Nanofiltration (NF) has attracted increasing attention during recent years due to the development of new applications. The advantage of NF compared with reverse osmosis (RO) and ultrafiltration (UF) is that it is possible to separate organic substances from some types of salts. It is, furthermore, also possible to separate different kinds of salts due to the negatively charged groups on the membra
