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BACKGROUND: Opioids are still widely prescribed to long-term pain patients although they are no longer recommended for long-term treatments due to poor evidence for long-term efficacy, risks of serious side effects, and the possibility of inducing opioid hyperalgesia. In a Cochrane study from 2017, the authors identified an urgent need for more randomized controlled trials investigating the effici
In this thesis, we present and study a few approaches for constructing controllers for uncertain systems, using a combination of classical control theory and modern machine learning methods. The thesis can be divided into two subtopics. The first, which is the focus of the first two papers, is dual control. The second, which is the focus of the third and last paper, is multiple-input multiple-outp
Background. The urokinase plasminogen activator (uPA) system is involved in tissue remodelling processes and is up-regulated in many types of malignancies. We investigated whether serum levels of different forms of soluble uPA receptor (suPAR) are associated with survival and in particular with prostate cancer and cardiovascular disease mortality. Methods. Using time-resolved fluorescence immunoas
The pathophysiology underlying impaired LV function in PAH remains unclear, with some studies implicating intrinsic myocardial dysfunction and others pointing to LV underfilling. Evaluation of pulmonary vein area (PVA) and flow may offer novel, mechanistic insight by distinguishing elevated LV filling pressure common in myocardial dysfunction from LV underfilling. This study aimed to elucidate LV
With the emergence of Alzheimer's disease (AD) disease-modifying therapies, identifying patients who could benefit from these treatments becomes critical. We evaluated whether a precise blood test could perform as well as established cerebrospinal fluid (CSF) tests in detecting amyloid-β (Aβ) plaques and tau tangles. Plasma %p-tau217 (ratio of phosporylated-tau217 to non-phosphorylated tau) was an
Sweden’s grocery distribution is routed through a limited number of upstream hubs and relies on corridors and ferry links. When disruptions affect a hub or a critical link, reallocations propagate fast and travel times increase, with some areas losing coverage temporarily. Decentralising the whole system is costly, so targeted resilience options must be evaluated. The purpose of this thesis is to
Title: Music-esthetical productions in the educational work - a case study of the Allvar Gullstrand highschool. Problem: A problem associated with working with project- and thematic studies which result in esthetical productions is that it often demands extra effort and time beyond the schedule to carry the production through. There are no instructions saying that schools are to work with this ki
Förekomsten av tekniska standarder är fundamental för den tekniska utvecklingen och medför flera konkurrensfördelar. Standardisering kan emellertid riskera att vara konkurrenshämmande i samband med patentinnehavares användning av de rättsmedel som står till deras förfogande. Så är fallet när patenterad teknik implementeras i standarder och får status som standardessentiella patent. I utbyte mot deThe presence of technical standards is fundamental to the technical development and entails several competitive advantages. Standardization may, however, risk being anticompetitive in relation to patent holders’ use of legal remedies available to them. This is the case when patented technology is implemented in standards and is given the status as standard essential patent. In exchange for the pos
This thesis explores the use of Large Language Models (LLMs) to convert natural language questions into SQL (Structured Query Language) queries within the field of sports analytics, with a focus on a real-world use case for Spiideo, a provider of cloud-based video analysis tools. The study compares different system designs, including single-agent and multi-agent setups, various prompting strategie
The pulmonary route has emerged as a promising strategy for delivering protein therapeutics, particularly for patients suffering from respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and pulmonary infections. This project investigated the effect of operating parameters of a laboratory spray dryer on the characteristics of powders composed of Bovine Serum Albumin
Low-temperature vacuum spray drying (VSD) is a potential drying approach for probiotic and live biotherapeutic product (LBP) formulations. This thesis investigated VSD for Limosilactobacillus reuteri DSM 17938 as a model probiotic strain, with the aim of identifying a feasible lab-scale operating window and using data-driven analysis to support process understanding. Sucrose–maltodextrin formulati
The aim of this study was to examine how the guidelines of interprofessional cooperation regarding clients with substance drug abuse problems and mental illness are implemented between the organisations of social services and healthcare. The study was performed in four Swedish small municipalities. The survey is based on the perspective of the staff from social service and also examines what strat
The awareness of problems concerning arsenic contaminated drinking water sources has during recent years increased. WHO (World Health Organization) decided in 1993 to lower the recommended limit of arsenic in drinking water from 50 μg/l to 10 μg/l, mainly due to observations of its carcinogenicity. New places where the WHO limit for arsenic is exceeded are constantly discovered all over the world.
The awareness of problems concerning arsenic contaminated drinking water sources has during recent years increased. WHO (World Health Organization) decided in 1993 to lower the recommended limit of arsenic in drinking water from 50 μg/l to 10 μg/l, mainly due to observations of its carcinogenicity. New places where the WHO limit for arsenic is exceeded are constantly discovered all over the world.
The aim of this thesis is to examine how the production and consumption of milk in the modern and post-modern Swedish society can be said to reflect general cultural and societal development. Focus is put on how it is affected by notions of the cartesian dichotomy between nature and culture. This is achieved using literature drawing on several disciplines relevant to the interdisciplinary field of
Departing from the high level of health issues that exists among LGBTIQ youth in Sweden, this study examines how pedagogues in preschools in Malmö implement LGBTIQ issues based on queer theory, intersectionality and critical race studies. The research takes a qualitative approach and uses material from interviews and participatory observations conducted at two preschools in Malmö. The material is
Abstract Title: Green Area Factor in affect – How does the implementation of Green Area Factor requirements work in Sweden today? Author: Johanna Hallberg Supervisors: Anne Landin – Professor, Department of Construction Management, Lund University Dagmar Gormsen – Social development leader at Sustainable Business Development at Skanska Sweden AB Examiner: Stefan Olander – Docent, Department of C
This study presents an empirical investigation of i) testing the Granger Causality between economic growth and aggregated carbon dioxide (CO2) emission; and economic growth and disaggregated CO2 emission from burning fossil fuel coal, oil and natural gas respectively; ii) the potential impact on economic growth if countries substitute CO2 emission from dirty energy, coal, by emission from relative
