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Objective: The aim of this study was to assess the risk of serious adverse effects after radiotherapy (RT) with curative intention and radical prostatectomy (RP). Materials and methods: Men who were diagnosed with prostate cancer between 1997 and 2012 and underwent curative treatment were selected from the Prostate Cancer data Base Sweden. For each included man, five prostate cancer-free controls,
Background: Lung cancer is one of the most common cancers in the world. Early detection and correct staging are fundamental for treatment and prognosis. Positron emission tomography with computed tomography (PET/CT) is recommended clinically. Silicon (Si) photomultiplier (PM)-based PET technology and new reconstruction algorithms are hoped to increase the detection of small lesions and enable earl
Human milk fat is a concentrated source of energy and provides essential and long chain polyunsaturated fatty acids. According to previous experiments, human milk fat is partially lost during continuous enteral nutrition. However, these experiments were done over relatively short infusion times, and a complete profile of the lost fatty acids was never measured. Whether this loss happens considerin
BACKGROUND: Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely investigated. The aim of this study was to investigate associations between five lifestyle factors and incident multimorbidity of cancer and cardiometabolic diseases. METHODS: In thi
BACKGROUND—: Thrombus aspiration during percutaneous coronary intervention (PCI) for the treatment of ST elevation myocardial infarction (STEMI) has been widely used; however, recent trials have questioned its value and safety. In this meta-analysis, we, the trial investigators, aimed to pool the individual patient data from these trials to determine the benefits and risks of thrombus aspiration d
Objectives: Increasing incidences of non-typeable Haemophilus influenzae (NTHi) with β-lactam resistance mediated through mutations in penicillin-binding protein 3 (BLNAR or rPBP3) have been observed in the past decades. Recently, an rPBP3 NTHi sequence type (ST) 14 with PBP3 type IIb/A caused a disease outbreak in a nursing home in Sweden with severe outcomes, indicating increased bacterial virul
Wohlers Associates, Inc., recognized widely as the leading consulting firm and preeminent authority on additive manufacturing and 3D printing worldwide—terms that are used interchangeably—today announced the publication of the Wohlers Report 2016. The 2016 edition marks the 21st consecutive year of its availability. According to Wohlers Report 2016, the additive manufacturing (AM) industry, consis
Objective: To investigate whether the Multi-Biomarker Disease Activity (MBDA) score predicts optimal add-on treatment in patients with early rheumatoid arthritis (RA) who were inadequate responders to MTX (MTX-IRs). Methods: We analyzed data from 157 MTX-IRs (with a Disease Activity Score using the erythrocyte sedimentation rate [DAS28-ESR] >3.2) from the Swedish Pharmacotherapy (SWEFOT) trial who
The tumor microenvironment can act so as to stimulate or reject tumor cells. Among the determining factors are cytokines produced, for example, by infiltrating immune cells, tumor cells, and fibroblasts. External radiotherapy has been shown to be able to activate an immune response against tumor cells with cytokine signaling as an important part of the activation. The aim of this study was to eval
Aim: The aim of this study is to evaluate the quality of data on endometrial (EC) and ovarian, fallopian tube, peritoneal, abdominal or pelvic cancers (OC) registered in the Swedish Quality Register of Gynecologic Cancer (SQRGC). Method: A random sample of 500 patients was identified in the SQRGC and their medical charts were reviewed for re-abstraction of 31 selected core variables by an independ
Huntington's disease is an autosomal dominant disease which presents with striatal and cortical degeneration causing involuntary movements, dementia and emotional changes. We employed 16-week-old transgenic Huntington mice (R6/1 line developed by Bates and coworkers) that express exon 1 of the mutant human Huntington gene with 115 CAG triplet repeats. At this age, R6/1 mice do not exhibit an overt
A two-phase hollow-fiber (HF) liquid-phase microextraction (LPME) method was developed for determination of a quaternary ammonium compound surfactant, dicocodimethylammonium chloride, in aqueous samples. The porous HF was fixed on a metal rod support and was impregnated with approximately 6.6 mu L of organic extractant, which was immobilized in the HF pores. Surfactant extraction was facilitated b
What does recognition mean for people whose sexuality has for a long time been criminalised? Over the last years, the recognition of India’s queers has been the focus of numerous contestations as a result of the complex developments around Section 377 of the Indian Penal Code, which criminalises ‘carnal acts against the order of nature’. The Section had been partially repealed in 2009 by the Delhi
Experimental results for Na and K deposited at 100 K on the A1(100) surface using low-energy electron diffraction and high-resolution core-level spectroscopy are presented. Our results show that from a coverage of 0.20 monolayers (ML), Na condenses into dense islands with a local Na coverage of 0.50 ML. In the case of K, the overlayer condenses into islands at a coverage of 0.18 ML, with a local c
Som följd av klimatförändringar kommer klimatanpassningsåtgärder att bli nödvändiga för att skydda mot effekterna av det förändrade klimatet. Det förändrade klimatet kommer innebära att risken för översvämningar och erosion ökar längs med Sveriges kuster, sjöar och vattendrag. Vem det är som bär ansvaret för att se till att dessa klimatanpassningsåtgärder kommer till stånd råder det en osäkerhet kAs a result of climate change, our society will need to start to adapt to the changing conditions. With these changes the risk of floods, races, spills and erosion along the coasts, lakes and streams of Sweden will increase. The need to take action to counteract these impending risks is strong but how is going to take responsibility for these actions? The purpose of the report is to investigate th
Mäns våld mot kvinnor har på senare tid blivit ett alltmer erkänt samhällsproblem. En vanlig uppfattning är att våldet till största del utgörs av fysiska gärningar men ett psykiskt nedbrytande och kontrollerande beteende är dock mer vanligt förekommande. Tydligt är att mäns våld mot kvinnor till stor del grundas i den mellan könen existerande maktobalansen vilket är en viktig utgångspunkt i förståMen’s violence against women has in recent times become a more and more recognised social issue. It is a common misconception that the violence mainly consists of physical abuse, but psychological abuse in terms of controlling and degrading behaviour is somewhat more common. It is apparent gender structures serves as a base from which men’s violence against women can originate and grow. This is im
Förutsägande om klimatförändringar och nederbördsmönster i den närmaste framtiden samt urbanisering leder till högre volymer av avrinning, vilket i sin tur utmanar hållbarheten och funktionaliteten hos stadsdräneringsnät. För att förstå hur dessa förändringar kommer att påverka den befintliga infrastrukturen i stadsområden behövs integrerad programvara för urban vattenmodell för att identifiera efThe predictions on climate change and precipitation patterns in the near future, as well as urbanization, lead to higher volumes of runoff, which in turn challenge the sustainability and functionality of urban drainage pipe networks. In order to understand how these changes will affect the existing infrastructure in urban areas, integrated urban water model software are needed to identify effectiv
