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ABSTRACT: BACKGROUND: There is an insufficient number of reliable prognostic and response predictive biomarkers in colorectal cancer (CRC) management. In a previous study, we found that high tumour tissue expression of tumour-associated trypsin inhibitor (TATI) correlated with liver metastasis and an impaired prognosis in CRC. The aim of this study was to investigate the prognostic validity of ser
A low phase noise CMOS LC quadrature VCO (QVCO) with a wide frequency range of 3.6-5.6 GHz, designed in a standard 0.18 /spl mu/m process for multi-standard front-ends, is presented. A significant advantage of the topology is the larger oscillation amplitude when compared to other conventional QVCO structures. The QVCO is compared to a double cross-coupled LC-tank differential oscillator, both in
PURPOSE: The purpose of this study was to observe sickness absence before and after the cancer diagnosis among cancer patients with five common forms of cancer. METHODS: Using cohort data, we observed sick leave in the pre- and post-diagnostic phase among patients with colon, rectal, breast, prostate, or lung cancer (n = 2,738). We also identified reference subjects without cancer (total n = 12,24
Background: Evidence-based guidelines should in most cases be followed also in the treatment of elderly. Older people are often suboptimally treated with the recommended drugs. Objectives: To describe how well general practitioners adhere to current guidelines in the treatment of elderly with cardiovascular disease and evaluate local education as a tool for improvement. Method: Data was colle
The aim of this thesis is to argue for the definition of the German present tense as a non-past tense. Three descriptive levels are distinguished: the semantic, the conceptual and the "level of reality" ( "Wirklichkeitsebene" ). It is assumed that there is no 1:1 correspondence between the semantic and the conceptual level. The former divides time into two temporal spheres: the past and the non-pa
In the evolution of bird migration, partial migration is assumed to be an important intermediate step between migration and residency. Partial migration is characterised by the existence of both migratory and resident individuals in a given population. Compared to regular migration, relatively little is known about partial migrants and their migratory performances. In my thesis, I have studied th
Respiration in animals, plants and many bacteria is dependent on heme A, which functions as a prosthetic group in a-type cytochromes (terminal energy-transducing oxidases in the electron transport chain that reduce molecular oxygen to water). Heme A synthase catalyses a chemically very demanding reaction, the conversion of one specific methyl side-group of heme O to a formyl group of heme A. This
'Sustainability' is an emerging issue that product development engineers must engage with to remain relevant, competitive and, most importantly, responsible. Yet, on examining the term 'sustainable', a plethora of definitions emerges, many of which are contradictory and confusing. This confusion and a general lack of understanding means that sustainability often gets relegated to an afterthought o
The public sphere and public reason have recently become key ideas in global governance, with most scholars expressing related transparency and accountability concerns. This article contends that if transnational public sphere(s) and the use of reason in global policy-making aim to reinforce the common good and justice, they must go beyond the procedural concerns of transparency and accountability
Cancer is one of the leading causes of death worldwide, but reliable diagnosis and staging can contribute to optimal treatment planning, and is a crucial factor in reducing mortality and maintaining quality of life. Soft tissue mechanical properties are promising indicators of cancer that can be assessed non-invasively using functional imaging. Additionally, lymphatic involvement is considered a k
A maximum likelihood methodology for a general class of models is presented, using an approximate Bayesian computation (ABC) approach. The typical target of ABC methods are models with intractable likelihoods, and we combine an ABC-MCMC sampler with so-called "data cloning" for maximum likelihood estimation. Accuracy of ABC methods relies on the use of a small threshold value for comparing simulat
Increasing security in transports without negatively affecting the logistical flow makes efficiency a critical factor. To achieve a viable end-to-end security solution in a supply chain, with complex network of dependencies, a holistic perspective is required. With focus on dual use measures this pilot project, performed in close cooperation between Volvo Technology and Saab, involves important st
The hydrolysis of sphingomyelin (SM) generates important signals regulating cell proliferation and apoptosis. Acid and neutral sphingomyelinases (SMase) have been identified and their biological effects intensively studied. We recently found in human bile a novel alkaline SMase that may have important roles in hepatobiliary diseases. In this work, we purified the enzyme and studied the factors inf
The demand for rare earth elements (REEs) is growing, while the future supply is uncertain. Their unique electronic characteristics make them irreplaceable, and the commercial value of pure fractions is high. A model-based simulation study is presented that compares batch chromatography with the twin-column MCSGP (multicolumn countercurrent solvent gradient purification) process for ion-exchange c
Abstract in UndeterminedThe Doughnut fallacy hypothesis posits that many debaters tend to sup- port their arguments using collapsed generalities – such as “democracy” – with pur- ported self-evident positive or negative qualities as philosophical grounding. This will leave an often unexamined hole in the middle of the debate which will stunt delib- erative processes, as it effectively stops delibe
The small size of the billions of migrating songbirds commuting between temperate breeding sites and the tropics has long prevented the study of the largest part of their annual cycle outside the breeding grounds. Using light-level loggers (geolocators), we recorded the entire annual migratory cycle of the red-backed shrike Lanius collurio, a trans-equatorial Eurasian-African passerine migrant. We
Older adults living in rural and urban areas have shown to distinguish themselves in technology adoption; a clearer profile of their Internet use is important in order to provide better technological and health-care solutions. Older adults' Internet use was investigated across large to midsize cities and rural Sweden. The sample consisted of 7181 older adults ranging from 59 to 100 years old. Inte
Context-aware applications generally need to retrieve various kinds of dynamic context data from a large number of context sources. A middleware managing context sources must provide an efficient context lookup mechanism to ease application development. In this paper, we categorize the context sources as operating spaces and propose semantic peer-to-peer overlays over these spaces to accelerate dy
