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Background: Integument-related toxicities are common during epidermal growth factor receptor (EGFR)-targeted therapy. Panitumumab is a fully human monoclonal antibody targeting the EGFR that significantly improves progression-free survival when added to chemotherapy in patients with metastatic colorectal cancer who have wild-type (WT) KRAS tumours. Primary efficacy and tolerability results from a
Background: Serum creatinine-based estimates of GFR may be inaccurate in the elderly and there is need for improvement. Serum Cystatin C, not being influenced by muscle volume, may be more accurate. Material and methods: GFR was measured with plasma clearance of iohexol in 50 elderly persons aged >70 years. Blood tests were drawn for analysis of creatinine, albumin and urea. Cystatin C was analyse
OBJECTIVE. Screening examination for retinopathy of prematurity is distressing and painful. The aim of the present study was to investigate whether a Newborn Individualized Developmental Care and Assessment Program intervention during a retinopathy of prematurity examination results in less adverse behavioral, pain, and stress responses as compared with standard care. METHODS. The first 2 eye exam
Abstract Author: Annelie Paulsson Title: They are so charming individuals – About Children’s Advocacy centres (”Barnahus”), collaboration and the child’s right to be listen to. Supervisor: Claes Levin Assessor: Staffan Blomberg The purpose of this study was to examine how children are treated, to what extent they are allowed a voice of their own, and whether or not this voice is heard in the proce
En person som blivit så svårt skuldsatt att vederbörande inte kan antas bli fri från sina skulder inom en överskådlig tid kan i Sverige ansöka om skuldsanering hos Kronofogdemyndigheten (KFM). Om en skuldsanering beviljas innebär detta att gäldenären helt eller delvis befrias från ansvaret att betala sina skulder. För att överhuvudtaget kunna bli föremål för skuldsanering krävs dock bland annat at
Zambezi River Basin is an international river basin which sustains life of about 30 million people in its riparian countries: Angola, Botswana, Malawi, Mozambique, Namibia, Tanzania, Zambia and Zimbabwe. The main stream of the river enters to Mozambique with average flow of about 2330 m3/s and reaches the outfall in the Indian Ocean with about 4134 m3/s. This makes both the activities in the upstr
A combination of acoustic trapping and impedance spectroscopy for micrometer-sized objects is here presented for the first time. Acoustic trapping has proven to be a well-functioning method for non-contact immobilization and positioning of particles or cells in microfluidic channels. The combination with impedance spectroscopy allows for simultaneous electrical measurements on the trapped objects.
Företagsskattekommitténs huvudförslag för nytt bolagsskattesystem är ett obeprövat beskattningssystem som inte finns i något annat land i världen. Denna uppsats behandlar både förslagets materiella innehåll och förslagets skattemässiga effekter för företag och branscher i Sverige. Kommitténs förslag är komplext och medför stora förändringar jämfört med dagens bolagsbeskattning. Förslaget innehålThe main proposal for a new corporate tax system from the Swedish Committee on Corporate Taxation is an untested system that does not exist in any other country in the world. This paper both deals with the content of the proposal and the tax effects of the proposed rules for companies and various lines of businesses in Sweden. The Committee’s proposal is complex and entails significant changes in
Molecular sensing in the lingual mucosa and in the gastro-intestinal tract play a role in the detection of ingested harmful drugs and toxins. Therefore, genetic polymorphisms affecting the capability of initiating these responses may be critical for the subsequent efficiency of avoiding and/or eliminating possible threats to the organism. By using a tagging approach in the region of Taste Receptor
Background Long-term outcome after hematopoietic stem cell transplantation including late transplant-related events is of increasing interest. The aim of this study was to evaluate the incidence of cardiovascular events after allogeneic HSCT and to search for their risk factors. Design and Methods This is a retrospective mutlicenter European Group of Blood and Marrow Transplantation (EBMT) analysi
Denna uppsats behandlar leverantörers möjligheter till skadestånd vid offentlig upphandling. De frågor som kommer att behandlas är under vilka förutsättningar en leverantör har rätt till skadestånd enligt lag om offentlig upphandling (LOU), huruvida det är möjligt för en leverantör att grunda sin skadeståndstalan direkt på skadeståndslagen (SkL) samt hur skadeståndet ska beräknas. Då lagstiftningeThis paper discusses suppliers' possibilities to recover damages at public procurement. The issues that will be addressed are the conditions under which a supplier is entitled to damages under the law on Public Procurement, whether it is possible for a supplier to base their claim for compensation directly on the Tort Liability Act, and how damages should be calculated. Since the legislation h
Sedan 2001 har EU-domstolen vid upprepade tillfällen framhållit att var och en som har lidit skada som orsakats av en överträdelse av EU:s konkurrensregler ska kunna kräva full ersättning för denna skada. Det har dock visat sig svårt för personer och företag som drabbats av en konkurrensskada att utnyttja denna EU-rättsliga rätt till ersättning. I syfte att främja skadeståndsprocesser baserade på Since 2001 the CJEU has repeatedly stated that, as a matter of EU law, any individual must be able to obtain compensation for harm suffered because of an infringement of EU competition law. As of today, victims of infringements of EU competition law are unable to effectively exercise that EU right. By introducing a Proposal for Directive, the Commission has taken a major step forward in promoting
Popular Summary Wildfire events are expected to increase with the changing climate; thereby increasing atmospheric, economic, and human health impacts. A better understanding of the evolution of wildfire events can benefit regional meteorology models and global atmospheric models. Because of this, an attempt at modeling the evolution of wildfire was undertaken using 8 years of daily meteorologica
Prior articles and reports have named Credit Default Swap (CDS) spreads as a plausible indicator of default risk. In this report, the authors present a significant correlation between CDS spreads and two other more acknowledged methods of measuring default risk probabilities; the modified Merton model and credit ratings from the rating institute Moody’s. The tests are implemented by Spearman’s ran
This study aims to evaluate the usability of ecotope maps to predict aquatic ecological consequences of floodplain landscape changes. If successful, this method will be applied to evaluate ecological rehabilitation measures that will be carried out in order to improve the ecological status of the large river plains. Ecological value is reflected in indicator metrics for fish, aquatic vegetation, a
När ett offentligt organ ägnar sig åt offentlig upphandling torde huvudsyftet vara att tillfredsställa ett behov av varor, tjänster eller byggentreprenader. En utgångspunkt för offentlig upphandling är att det är den upphandlande enheten som identifierar sitt behov och således avgör vad som ska upp¬handlas. Utöver syftet att tillfredsställa sitt primära upphandlingsbehov kan en upphandlande enhet When a public body engages in public procurement the main purpose for it to do so is arguably to satisfy a need for goods, services or works. A starting point for public procurement is that it is the procuring entity which identifies its own needs and thus determines what is to be procured. In addition to the purpose of satisfying its primary procurement needs, a contracting entity, however, may h
The purpose of this study is to see how much attenuation the hearing protection device (HPD) wearer gets using an insert-type HPD at work in real-world situations and to see if there is a relation between how the wearer puts his HPD in place and the surrounding noise leveL Five different companies were selected and aU together there were 43 participants. The test subjects work in such an environme
