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HAMLET (Human alphalactalbumin made lethal to tumor cells), a complex between the partially unfolded alphalactalbumin and oleic acid, was discovered by serendipity when anti-adhesive properties of human milk were examined. HAMLET kills tumor cells but not healthy differentiated cells. Native alphalactalbumin (HLA) can be conveted to HAMLET by a two-step process including: 1) calcium ion removal in
I Sverige är grundvatten är en av de huvudsakliga källorna för dricksvatten. Grundvattenmagasin kommer att påverkas av klimatförändringar genom förändrad effektiv nederbörd och således grundvattenbildning. Dessa vattenresurser ska finnas kvar för framtida generationer och det är därför av vikt att studera dem samt öka förståelsen kring dem. Sveriges miljömål kring grundvatten nämner ett behov av aIn Sweden groundwater is one of the primary sources for drinking water. Groundwater reservoirs will be affected by climate changes with changes in effective precipitation, which means changes in groundwater recharge. It is therefore of value to study and examine these water resources, so that they remain just that for the generations to come. Sweden’s environmental goals regarding groundwater sugg
Abstract Title: Experiences of managing change: a case study of middle managers experiences of managing in a changing organization Submission date: 23rd of May 2014 Course: BUSN49 Degree Project in Managing People, Knowledge and Change – Master Level Authors: Adam Lindroth & Sara Borg Supervisor: Kate Sullivan, Lund University, Sweden Keywords: Change management, organizational change, middl
Following the peace treaty between Sweden and the regency of Algiers in 1729, the first Swedish consulate was established in this city. One of the first employees at the consulate was a man named Carl Reftelius (d. 1758), who, after approximately two years of service, returned home and wrote the very first Swedish account of the city and its inhabitants: Historisk och Politisk Beskrifning Öfwer Ri
Återfall i brottslighet har under alla tider varit ett vanligt förekommande problem. Unga personer, dömda till sluten ungdomsvård, löper på grund av sin låga ålder extra stor risk att återfalla i brott. Svensk statistik uppvisar att så många som 60 procent återfaller i brottslighet redan inom ett års tid. Uppsatsens syfte är att utreda vilka orsaker som kan hänföras till återfall i brottslighet efRecidivism has always been a common problem. Young people, who are convicted and subjected to closed institutional youth care detention (LSU) runs, due to their young age, a particularly high risk to reoffend. Swedish criminal statistics shows that as many as 60 percent relapse into crime within a year. The purpose of this essay is to investigate the causes that can be attributed to relapse into c
Syftet med denna studie är att undersöka hur musiklärare arbetar kring demokratisk värdegrund, hur musiklärare uppfattar värdegrundsarbete och vilka möjligheter som ges till lärare och elever att utveckla förståelsen av vad demokratisk värdegrund är eller kan vara. Studiens data genererades genom en enkätstudie och en intervjustudie. Enkäten riktades mot elever och musiklärare från årskurs 7 till
Protected areas (PAs) embody a historical legacy of value contestation and human exclusion. While the rise of community-based conservation in the 1980s sought to reconfigure this mechanism by running a counter narrative arguing that biodiversity conservation and development were mutually reinforcing objectives, exclusionary PAs continue to maintain a strong position in the conservation discourse.
Tetra Pak delivers food packing services world-wide and uses multilayer packaging materials to protect the food product from being affected by the environment. Loss of adhesion between the polymer and the aluminium layer in Tetra Paks packaging materials has proven to be a serious problem casing the package to lose its integrity and the food product to spoil. The problem is relatively unstudied bu
Aims: This study surveyed individuals and caregivers of children who received teplizumab at stage 2 type 1 diabetes (T1D) to garner real-world experiences and their health outlook for the future following treatment with the first approved disease-modifying immune therapy for delaying the onset of Stage 3 T1D. Materials and Methods: This was a cross-sectional, observational, online survey (conducte
Recent literature in economics has highlighted that competition and symbolic awards can provide non-monetary incentives. In this paper, we report on a step contest that we carried out at a large Swedish workplace in order to test whether competition for symbolic awards can be used to promote physical exercise. Each individual was equipped with a pedometer and registered the number of steps daily d
Objective: To explore experiences with supervised group exercise during pregnancy in women with depression or low psychological well-being. Design: A qualitative descriptive study based on semi-structured, individual, in-depth interviews analyzed by means of thematic analysis. Setting: The Department of Obstetrics, Rigshospitalet, Copenhagen University Hospital, Denmark. Participants: Through a pu
Over one third of the population develops cancer during their life-time and stroke associated with malignancy accounts for 10% of all hospitalized patients. With and improved survival and better life quality of patients with cancer, cancer related stroke is likely to increase. It is crucial to early diagnose an underlying malignancy to optimize treatment. It is known that a major mechanism is canc
In this work, we present a stroboscopic detection technique for the study of oscillating nanoscale objects. This optical read-out gives a position accuracy better than 1 nm which is a fraction of both the diffraction limit and the pixel size. The advantage of this stroboscopic method compared to conventional time-averaging techniques, is the time-resolution it provides as well as being non-invasiv
Denna avhandling undersöker den svenska befolkningens attityder i förhållande till en ekosocial agenda utifrån ett hållbart välfärdsperspektiv. Forskare har länge angripit frågor om miljö och välfärd som två separata fält. De aktuella miljö- och klimatförändringarna visar dock att dessa två fält måste förstås i samklang med varandra om vi ska kunna ställa om till ett klimatneutralt samhälle där håThis thesis explores Swedish residents’ attitudes related to an eco-social agenda from a sustainable welfare perspective. It investigates public support for general policy goals related to an eco-social agenda as well as for specific eco-social policies. The thesis also analyses the significance of the individuals’ socioeconomic characteristics, their values, and the context they are situated in r
PARP14/BAL2 is a large multidomain enzyme involved in signaling pathways with relevance to cancer, inflammation, and infection. Inhibition of its mono-ADP-ribosylating PARP homology domain and its three ADP-ribosyl binding macro domains has been regarded as a potential means of therapeutic intervention. Macrodomains-2 and -3 are known to stably bind to ADP-ribosylated target proteins, but the func
IMPORTANCE: Although occupational balance (OB) is a construct of importance to occupational therapy, existing OB assessments have not been validated in clinical populations. OBJECTIVE: To examine the validity and reliability of the 11-item version of the Occupational Balance Questionnaire (OBQ11) in U.S. adults with Type 1 diabetes. DESIGN: Data were analyzed from adults with Type 1 diabetes enrol
