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Health utility in preclinical and prodromal Alzheimer's disease for establishing the value of new disease-modifying treatments—EQ-5D data from the Swedish BioFINDER study

Quality of life and health utility are important outcomes for patients with Alzheimer's disease (AD) and central for demonstrating the value of new treatments. Estimates in biomarker-confirmed AD populations are missing, potentially delaying payer approval of treatment. We examined whether health utility, assessed with the EuroQoL-5 3-level version (EQ-5D-3L), differed between individuals with a p

Synthesis of starch nanoparticles and their applications for bioactive compound encapsulation

In recent years, starch nanoparticles (SNPs) have attracted growing attention due to their unique properties as a sustainable alternative to common nanomaterials since they are natural, renewable and biodegradable. SNPs can be obtained by the breakdown of starch granules through different techniques which include both physical and chemical methods. The final properties of the SNPs are strongly inf

Using service simulation to analyse the satisfaction with the processes of intensive care unit in the hospital: the perspective of the patient and the family

In the hospital, intensive care unit (ICU) is an isolated space where patients with acute symptoms are treated. When the patients are in ICU, their families are usually in psychological crisis and under great pressure. The value of ICU is thus to provide a complete ICU service by which not only the patients receive good treatment, but the feelings of family members are also considered and managed.

Systematic Synthesis of Substituted Phosphido-bridged Osmium Clusters

The labilised clusters [Os3(CO)11–nLn(NCMe)][n= 1, L = PMe3 or CNBut; n= 2, L = P(OMe)3] have been prepared. The reaction of [Os3(CO)11 –nLn(NCMe)] or [Os3(CO)10{P(OMe)3}(NCMe)] with either [Os3(CO)11(PH3)] or [Os3(µ-H)(CO)10(µ-PH2)] led to the formation of the phosphide-bridged clusters [Os6(µ-H)(CO)21{P(OMe)3}(µ-PH2)], [Os6(µ-H)(CO)21(PMe3)(µ-PH2)], [Os6(µ-H)(CO)21(CNBut)(µ-PH2)], [Os6(µ-H)(CO)2

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OBJECTIVE: To test a simplified blood pressure device called Rastreometro that could be used by the Health Agents.METHODS: The Rastreometro has been developed from an ordinary aneroid sphygmomanometer, in which the numeric display is covered by an adhesive with a red zone, indicating pressures equal or above 140 mmHg and a yellow zone indicating pressures below 140 mmHg. The onset of oscillations

Temperature distribution and current system in a convectively mixed lake

During spring and autumn, many lakes in temperate latitudes experience intensive convective mixing in the vertical, which leads to almost isothermal conditions with depth. Thus the regime of turbulence appears to be similar with that characteristic of convective boundary layers in the atmosphere. In the present paper a simple analytical approach, based on boundary-layer theory, is applied to conve

Incidence Rate of Hand Eczema in Different Occupations : A Systematic Review and Meta-analysis

Hand eczema is a chronic disease that results in economic and psychosocial burdens. The aim of this study was to systematically review and assess the magnitude of the association between exposure related to occupations and the incidence rate of hand eczema. A systematic search in PubMed, EMBASE, CINAHL and Cochrane databases, from inception to September 2017, of full-text observational studies rep

A gap between the philosophy and the practice of palliative healthcare : sociological perspectives on the practice of nurses in specialised palliative homecare

Palliative care philosophy is based on a holistic approach to patients, but research shows that possibilities for living up to this philosophy seem limited by historical and administrative structures. From the nurse perspective, this article aims to explore nursing practice in specialised palliative homecare, and how it is influenced by organisational and cultural structures. Qualitative, semi-str

Crystallization kinetics and the role of equilibrium in carbon capture systems with gas-liquid-solid equilibrium : Case study of AMP in NMP solution

A semi-empirical power law-based theory has been developed to model the crystallization kinetics in precipitating systems for CO2 capture. A more reliable activity-based theory and simplified concentration-based crystallization kinetics have also been derived for a gas-liquid-solid system in which CO2 evolution might be unavoidable during the experiments performed to determine crystallization kine

Estrogen and progesterone receptor analyses in more than 4000 human breast cancer samples : A study with special reference to age at diagnosis and stability of analyses

Estrogen (ER) and progesterone receptors (PgR) were measured in the same laboratory in more than 4000 breast cancer biopsy samples obtained from 15 different hospitals during ten years. ER was measured with isoelectric focusing and PgR with the dextran-coated charcoal method and Scatchard analysis. The distribution pattern for both ER and PgR was during this time period and for the different hospi

Place satisfaction revisited : residents’ perceptions of “a good place to live”

Purpose: Using service-based logic as its theoretical lens, this study aims to approach residents’ place satisfaction in a novel way. The purpose is to explore residents’ perception of the place in which they live and to shed new light on their place satisfaction. Design/methodology/approach: The paper is based on explorative qualitative focus group research. Data were collected in two typical mun

Which acne treatment has the best influence on health-related quality of life? Literature review by the European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient Oriented Outcomes

According to results of a recent literature search performed by the European Academy of Dermatology and Venereology (EADV) Task Forces (TF) on Quality of Life and Patient Oriented Outcomes (QoL and PO) and Acne, Rosacea and Hidradenitis Suppurativa (ARHS), most of the publications where health-related (HR) QoL of acne patients was studied were clinical trials. Members of the EADV TF on QoL and PO

Fixation classification: how to merge and select fixation candidates

Eye trackers are applied in many research fields (e.g., cognitive science, medicine, marketing research). To give meaning to the eye-tracking data, researchers have a broad choice of classification methods to extract various behaviors (e.g., saccade, blink, fixation) from the gaze signal. There is extensive literature about the different classification algorithms. Surprisingly, not much is known a

Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk

Diabetes is a complex and multifactorial disease that affects millions of people worldwide, reducing the quality of life significantly, and results in grave consequences for our health care system. In type 2 diabetes (T2D), the lack of β-cell compensatory mechanisms overcoming peripherally developed insulin resistance is a paramount factor leading to disturbed blood glucose levels and lipid metabo

The use of drones in the spatial social sciences

Drones are increasingly becoming a ubiquitous feature of society. They are being used for a multiplicity of applications for military, leisure, economic, and academic purposes. Their application in academia, especially as social science research tools, has seen a sharp uptake in the last decade. This has been possible due, largely, to significant developments in computerization and miniaturization

Elevated pulse pressure preceded incident chronic kidney disease in the general older population in Sweden

Arterial stiffness (AS) and chronic kidney disease (CKD) are common in the older population. AS results in increased pulsatile pressure, elevated pulse pressure (PP), and is linked to hypertension. PP is a surrogate for AS. The kidney has low vascular resistance mechanisms, presumably making it vulnerable to the increased pulsatile pressure and hypertension associated with AS. The aims of this stu

Gender Smart Mobility : Concepts, Methods, and Practices

This book presents gender and diversity in smart transport as a cutting-edge issue in urban contexts around the globe. It addresses new challenges and possibilities related to the smart transport sector. It demonstrates how gender and diversity are entangled in concepts and various forms of current smart mobility practices in policy, planning, and innovation. Gender Smart Mobility is presented as