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Background: The pathological process in Alzheimer’s disease (AD) probably starts decades before the onset of symptoms and the clinical AD diagnosis. In patients with AD, the level of cerebrospinal fluid (CSF) amyloid-β1-42 (Aβ42) is usually lower, and the levels of total tau (T-tau) and phosphorylated tau (P-tau) higher than in healthy elderly people. However, the cutoffs differ between studies an

The Strengths and Difficulties Questionnaire (SDQ) has been used among Swedish children since 1996, usually the parent or the teacher version. The self-report version was originally developed for children aged 11-16 years. The aim of this study was to investigate the application of the Swedish self-report version to a representative sample of 1015 senior high school students aged 17-19 years. Girl

The number of discovered non-radially pulsating white dwarfs (WDs) in cataclysmic variables (CVs) is increasing rapidly by the aid of the Sloan Digital Sky Survey (SDSS). We performed photometric observations of two additional objects, SDSS J133941.11+484727.5 (SDSS 1339), independently discovered as a pulsator by Gansicke et al., and SDSS J151413.72+454911.9, which we identified as a CV/ZZ Ceti h

Objectives The aim was to psychometrically evaluate the Swedish version of the Multidimensional Pain Inventory (MPI-S) and the “brief screening version of MPI-S” for use in an elderly sample. Methods This study comprised 175 people aged 76–99 years reporting pain and in need of help to manage daily living. The instrument’s factor structures were investigated through factor analyses, convergent

Purpose. This article describes an ex vivo method to recondition and transplant rejected donor lungs. Description. A 19-year-old man was brain dead after a traffic accident. A roentgenogram showed bilateral lung contusion. He had ongoing intratracheal bleeding. After optimizing ventilator treatment and suctioning the airways, PaO2 was 9 kPa (67.5 mm Hg) on FiO(2) = 0.7. The lungs were rejected by

Eemian-Weichselian sequences, located outside the maximum limit of the Late Weichselian ice sheet, provide excellent opportunities for the discovery of continuous sedimentary records encompassing the whole Last Interglacial/Glacial cycle. Such a sequence is recorded in a borehole (117P) through the succession in a small kettlehole lake located at Medininkai, eastern Lithuania. The succession consi

Enzymatic hydrolysis is an agro-processing aid that can be utilized in order to improve nutritional quality of protein extracts from many sources. In this study, protein extracts from ungerminated and/or germinated local Egyptian soybean and lupin flours were hydrolyzed using the enzyme papain. The hydrolysis processes were carried out for 2 h and aliquots were withdrawn at different time interval

High-spin states of T-z = 1 nuclei were studied with the reactions Ni-58(Si-28,3 alpha)Kr-74,Ni-58(Si-28,2 alpha)Sr-78, and Ni-58(Si-28,2p2n)Zr-82 at 130 MeV beam energy. The Gammasphere array in conjunction with the 4 pi charged-particle detector array Microball was used to detect gamma rays in coincidence with evaporated light charged particles. The known pi = +, alpha = 0 yrast bands were exten

To meet the economic requirements of power output, the increased inlet temperature of modern gas turbines is above the melting point of the material. Therefore, high-efficient cooling technology is needed to protect the blades from the hot mainstream. In this study, film cooling was investigated in a simplified channel. A bulge located upstream of the film hole was numerically investigated by anal

Botswana has figured widely as the exceptional African growth success story and has been frequently cited in scholarship that supports the view that African and other less developed economies are capable of rapid economic growth as long as the internal institutional framework and development policies are right. A shortcoming of the literature on African economic performance to date is that it has

Context: Offspring of women with gestational diabetes (O-GDM) or type 1 diabetes mellitus (O-T1DM) have been exposed to hyperglycemia in utero and have an increased risk of developing metabolic disease in adulthood. Design: In total, we recruited 206 adult offspring comprising the two fetal hyperglycemic groups, O-GDM and O-T1DM, and, as a control group, offspring from the background population (O

Cloud computing technology provides the means to share physical resources among multiple users and data center tenants by exposing them as virtual resources. There is a strong industrial drive to use similar technology and concepts to provide timing sensitive services. One such domain is a chain of connected virtual network functions. This allows the capacity of each function to be scaled up and d

In this work, we extend the popular sparse iterative covariance-based estimator (SPICE) by generalizing the formulation to allow for different norm constraint on the signal and noise parameters in the covariance model. For any choice of norms, the resulting generalized SPICE method enjoys the same benefits as the regular SPICE method, including being hyperparameter free, although the choice of nor

A10K (A=alanine, K=lysine) model peptides self-assemble into ribbon-like β-sheet aggregates. Here, we report an X-ray diffraction investigation on a flow-aligned dispersion of these self-assembly structures. The two-dimensional wide-angle X-ray scattering pattern suggests that peptide pack in a two-dimensional oblique lattice, essentially identical to the crystalline packing of polyalanine, An (fo

Mitigation of greenhouse gas (GHG) emissions is essential for us humans to curb climate change. Around a fifth of the anthropogenic GHG emissions stem from the construction sector. Much come from energy used for space and water heating within buildings, but an increasing proportion comes from the manufacturing of the building materials and is virtually embodied within buildings. This is called Emb

The aim of this study was to describe and analyze the criminal gang members' experiences of the exit process. What we mean by the exit process is the way in and out of gang crime and the maintenance of the new role of non- criminal gangs.We have, through qualitative semi-structured interviews interviewed former criminal gang members and analyzed their experiences using Ebaughs (1988) theory ab

When designing and implementing a prototype supporting inter-destination media synchronization – synchronized playback between multiple devices receiving the same stream – there are a lot of aspects that need to be considered, especially when working with unmanaged networks. Not only is a proper streaming protocol essential, but also a way to obtain and maintain the synchronization of the clocks o

Prostata cancer är den vanligaste cancerdiagnosen bland svenska män och den tredje vanligaste i värden. Sjukdomen behandlas vanligen med kirurgi och/eller strålbehandling. För att kunna förbättra strålbehandlingen är det önskvärt med en biologisk markör som kan visa responsen på behandlingen tidigt, redan under pågående behandling. På så sätt kan behandlingen anpassas till patienten, genom att ändPurpose: to develop a robust protocol optimized for measurement of ADC and use it to determine the precision of ADC measurements of prostate but also to determine the accuracy and precision of volume measurements of the prostate. Materials and methods: Using measurements from three volunteers an optimal protocol for ADC measurement in the prostate was determined. The study included both phantoms