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Extracellular vesicles (EVs) have emerged as a rich source of biomarkers providing diagnostic and prognostic information in diseases such as cancer. Large-scale investigations into the contents of EVs in clinical cohorts are warranted, but a major obstacle is the lack of a rapid, reproducible, efficient, and low-cost methodology to enrich EVs. Here, we demonstrate the applicability of an automated
Knowledge of dynamics in protein is very important in the description of protein function and molecular recognition. The thesis investigates protein dynamics on time-scales from milli- to sub-nanosecond, with focus on the latter, using NMR spin relaxation experiments on two proteins, the 138-residue carbohydrate recognition domain of galectin-3 (Gal3C) and the 56-residue B1 domain of bacterial pro
A solid oxide fuel cell (SOFC) is an electrochemical device that converts energy of a chemical reaction into electrical and thermal energy. Besides lack of pollutants and high electrical efficiency, one of the main advantages of SOFCs is the flexibility of using a wide range of fuels, i.e., natural gas, biogas, or any reactant with hydrogen as constituent. However, the use of hydrocarbon fuels can
STUDY QUESTION: Which substances and signal transduction pathways are potentially active downstream to the effect of FSH and LH in the regulation of human oocyte maturation in vivo? SUMMARY ANSWER: The regulation of human oocyte maturation appears to be a multifactorial process in which several different signal transduction pathways are active. WHAT IS KNOWN ALREADY: Many studies in animal species
Calcareous nannofossils evolved in the global ocean from the Carnian (early Late Triassic) and have contributed to the accumulation of biogenic calcium carbonate in marine sediments since then. Bio-diversification and bio-productivity became more significant in the Rhaetian (Late Triassic), representing an important period to understand the dynamics of calcareous nannofossil evolution. The calcare
The use of artificial neural networks for the purpose of image classification, together with the advancement in computational capabilities of edge devices, plays an important role in the new emerging 5G use case scenarios. However, one of the main challenges of applications involving the use of these networks in edge devices is still the limitation of computational resources. An alternative for sa
BACKGROUND: This study aimed to identify factors associated with health-related quality of life (HRQoL) and the burden on the relatives of older people with multi-morbidity.METHODS: A secondary analysis of baseline data from 296 dyads, including older patients with multimorbidity and their relatives, which were previously collected in a randomized study. The analysis was conducted to select correl
Introduction: In this study we investigate the risk of radiation-induced serious adverse event of the spine in a large cohort of consecutive retreated patients with palliative radiotherapy (RT) for metastatic cancer in the spine. Methods and materials: From 2010 to 2014, 2387 patients received spinal irradiation with a palliative intent for metastatic spinal cord compression at our institution. T
Objectives To estimate the risk of clinically diagnosed knee osteoarthritis (OA) after different types of knee injuries in young adults. Methods In a longitudinal cohort study based on population-based healthcare data from Skåne, Sweden, we included all persons aged 25-34 years in 1998-2007 (n=149 288) with and without diagnoses of knee injuries according to International Classification of Disease
Dust growth is often indirectly inferred observationally in star-forming environments,theoretically predicted to produce mm-sized particles in circumstellar discs, and also presumably witnessed by the predecessors of the terrestrial meteoritic record. For those reasons it is believed that young gas giants under formation in protoplanetary discs with putative circumplanetary discs (CPDs) surroundin
Experimental observation of 34Si as a proton bubble nuclei has heated up the interest in the study of exotic bubble shaped nuclei. In this work, some of the potential doubly bubble-like (for proton as well as neutron both simultaneously) cases have been explored using relativistic Hartree-Bogoliubov (RHB) in light mass region, specially around N or Z = 14. Further, the role of pairing and the evol
Scholars and activists opposing the killing of nonhuman animals have long shared the assumption that the invisibility of the animals killed for meat is one of the most sig- nificant factors when it comes to explaining how meat eating is perpetuated. However, a recent tendency towards a new visibility of these animals and their physical trans- formation into meat fundamentally challenges this assum
The behavior of Ethanol and seven fuels in the boiling point range of gasoline but with an Octane Number spanning from 69 to 99 was investigated in Partially Premixed Combustion. A load sweep was performed from 5 to 18 bar gross IMEP at 1300 rpm. The engine used in the experiments was a single cylinder Scania D12. To allow high load operations and achieve sufficient mixing, the compression ratio w
MutT homologue 1 (MTH1) removes oxidized nucleotides from the nucleotide pool and thereby prevents their incorporation into the genome and thereby reduces genotoxicity. We previously reported that MTH1 is an efficient catalyst of O6-methyl-dGTP hydrolysis suggesting that MTH1 may also sanitize the nucleotide pool from other methylated nucleotides. We here show that MTH1 efficiently catalyzes the h
Popular Abstract in Swedish Tvärströms mikrofiltrering är en teknik för att avskilja partiklar med en storlek på ungefär en mikrometer (en tusendel av en millimeter) från vätskor. Exempel på tillämpningar är avskiljning av jästceller från öl, och avskiljning av bakterier från mjölk. I mikrofiltrering används membran (filter) med porer med en storlek på 0.1 - 10 mikrometer. Mikrofiltreringsmembran Crossflow microfiltration is a technique to separate suspended particles (or cells or droplets) from liquids by use of a membrane that is permeable for the liquid but impermeable for the particles. The permeate flow drives particles to the membrane surface, where they may be deposited and form a fouling layer. To limit the growth of this fouling layer a flow is applied tangentially to the membrane
Several ribonucleases of the RNase A family function as antibacterial, anti-parasitic and anti-viral agents. In this work, we have shown that mRNAs encoding five of the six known human ribonucleases of the RNase A family are expressed in cultured human monocytes, and that ribonucleases are released by adherent monocytes in culture. Using a polyclonal antiserum prepared against recombinant protein,
This paper discusses effects of an increased reliance on professionals in industrial organizations and whether educational background or belongingness to professional groups may be linked to ways of working when supplying highly customized deliveries, and consequently the innovativeness of the organization. The study upon which this paper is based attaches to theories related to traditional indust
BACKGROUND: There is need for an updated systematic review of associations between occupational exposures and ischaemic heart disease (IHD), using the GRADE system.METHODS: Inclusion criteria: (i) publication in English in peer-reviewed journal between 1985 and 2014, (ii) quantified relationship between occupational exposure (psychosocial, organizational, physical and other ergonomic job factors)
The concept of ‘informality’ has become a trendy topic of research in the scholarly literature about post-Soviet societies. The amount of literature focusing on informal practices and networks in post-Soviet space has grown rapidly over last two decades, producing theoretically and empirically grounded accounts of different forms and manifestations of informality, such as clans and regional patron
