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BACKGROUND: A significant proportion of acute myocardial infarction (AMI) patients have characteristics of high-bleeding -risk (HBR). Their influence on ischaemic and bleeding-events in AMI all-comers is not well described.METHODS: AMI Patients in England and Wales (E&W), and Sweden between 2005 and 2019 were included from MINAP and SWEDEHEART national registries. Patients were categorised acc

We develop a theory and perform an experiment to study the effect of performance thresholds on effort and risk-taking in economic decisions. We find that effort unambiguously increases compared to the ``status quo" level, but that optimal effort varies non monotonically with the threshold level. The effect of a threshold on risk-taking in instead ambiguous, as risk taking increases for thresholds

Background: Metastasis-directed stereotactic body radiotherapy (MD-SBRT) has shown promise in retrospective and phase II studies for oligometastatic hormone-sensitive prostate cancer. However, prospective randomized phase III data—particularly in newly diagnosed cases and in combination with androgen deprivation therapy and next-generation androgen receptor pathway inhibitors—are limited. The METR

Low-temperature vacuum spray drying (VSD) is a potential drying approach for probiotic and live biotherapeutic product (LBP) formulations. This thesis investigated VSD for Limosilactobacillus reuteri DSM 17938 as a model probiotic strain, with the aim of identifying a feasible lab-scale operating window and using data-driven analysis to support process understanding. Sucrose–maltodextrin formulati

Fibromuscular dysplasia (FMD) mainly affects renal arteries. Percutaneous transluminal renal angioplasty (PTRA) and surgery are effective treatments, but longtime follow-up is lacking. Retrospective follow-up for 7.0 +/- 4.7 years of 69 consecutive patients ( age 44 +/- 13 years) treated for hypertension due to FMD, 59 patients underwent PTRA and eight patients surgery. In two patients no PTRA was

Neoglycoconjugates were prepared from mannan isolated from yeast Saccharomyces cerevisiae and activated by periodate oxidation to create aldehyde groups. Various degrees of oxidation introduced 11-28 aldehyde groups per mannan molecule and simultaneously resulted in a molar mass decrease from 46 to 44.5-31 kDa. The activated mannans were subsequently conjugated with bovine serum albumin forming ne

This paper presents a study of the pre-history and evolution of a regional innovation system initiative supporting activities at the intersection of traditional food production and modern biotechnology. Drawing on established ideas on the triple helix of industry, university and government and its impact on innovative capacity (as they are formulated in the regional innovation systems approach) an

The 40 in thick Untersberg section (Salzburg, Austria) of the Northern Calcareous Alps comprises the Palaeocene-Eocene transition and spans the upper part of calcareous nannoplankton zone NP9 and the lower part of zone NP10 (subzone NP10a). These zones are equivalent to planktonic foraminifera zone P5 and the lower part of zone P6 (sub-zone P6a). The succession was deposited in a lower bathyal slo

The transcription factor Rex has been implicated in regulation of the expression of genes important for fermentative growth and for growth under conditions of low oxygen tension in several Gram-positive bacteria. Rex senses the redox poise of the cell through changes in the NADH/NAD(+) ratio. The crystal structures of two essentially identical Rex proteins, from Thermus aquaticus and T. thermophil

Interest in the use of renewable raw materials for the production of various compounds that can replace fossil-based products is steadily increasing. In this study, the extraction and separation of hemicellulosic oligomers from spruce, to be used for the production of polymers such as hydrogels, was investigated. The focus of the study was on gel filtration of the solution from steam treatment of

Background The alpha-emitter radium-223 (Ra-223) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone-refractory prostate cancer. We aimed to study mature outcomes from a randomised, multicentre, phase II study of Ra-223. Methods Patients with hormone-refractory prostate cancer and bone pain needing external-beam radiotherapy were assigned to fou

A method was developed for the determination of benzene in urine. The sample was pumped through the donor channel of a membrane extraction unit with a micro-porous membrane, separating the donor channel from an identical acceptor channel purged with nitrogen. The analyte reached the acceptor channel by diffusion through the membrane and was then swept by the carrier to a solid sorbent tube, where

Alkyl glycosides are surfactants with good biodegradability and low toxicity, attractive to produce by an enzymatic method to get a well-defined product. In this paper, we report a novel thermostable variant of a family 3 β-glucosidase to be an efficient catalyst in alkyl-glucoside forming reactions using transglycosylation with hexanol or octanol as the acceptor molecule. The enzyme has an appare

The age-specific incidence of traumatic brain injury in older adults is rising in high-income countries, mainly due to an increase in the incidence of falls. The severity of traumatic brain injury in older adults can be underestimated because of a delay in the development of mass effect and symptoms of intracranial haemorrhage. Management and rehabilitation in older adults must consider comorbidit

An established negative association between socio-economic status (SES) and divorce has applied to most Western nations since 1960. We expected a positive association between SES and divorce for low-divorce contexts historically because only individuals in higher social strata had the resources to overcome barriers to divorce. According to Goode’s socio-economic growth theory, this relationship wa

2-amino-2-methyl-1-propanol (AMP) in dimethyl sulfoxide (DMSO) is a precipitating non-aqueous amine technology that can potentially lower the energy demand during CO2 removal from industrial flue gases compared to aqueous amine technologies. However, DMSO is hygroscopic and has a high possibility of absorbing water from humid flue gases, which can affect the physical properties of the system,

Background: Elevated red cell distribution width (RDW) is associated with increased postoperative mortality, but less is known about kidney outcomes. This study investigated the association between elevated preoperative RDW and postoperative worsening of long-term kidney function and incidence of acute kidney injury. Methods: This retrospective cohort study included patients ≥18 yr undergoing nonc

Background Suicide attempts are common in youth and have potentially lethal outcomes. Effective treatments targeting suicide attempts are scarce. Objective To assess the feasibility and preliminary efficacy of a family-based cognitive behavioural treatment relative to an active control for youth with suicidal behaviour. Methods 30 youths (93% female; mean (SD) age=14.6 (1.5) years) residing in Swe

Purpose: To study the feasibility of automatically identifying normal digital mammography (DM) exams with artificial intelligence (AI) to reduce the breast cancer screening reading workload. Methods and materials: A total of 2652 DM exams (653 cancer) and interpretations by 101 radiologists were gathered from nine previously performed multi-reader multi-case receiver operating characteristic (MRMC

The events of 9/11 and the subsequently launched ?war on terror? ushered in a new era of world politics. The new, global security agenda came to dominate international politics bringing about the securitization of a range of international policies. As a part of this process, international development cooperation has come to be increasingly articulated in the language of security as well, i.e. it h