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We present a compilation and analysis of 1099 Holocene relative shore-level (RSL) indicators located around the Baltic Sea including 867 relative sea-level data points and 232 data points from the Ancylus Lake and the following transitional phase. The spatial distribution covers the Baltic Sea and near-coastalareas fairly well, but some gaps remain mainly in Sweden. RSL data follow the standardize
INTRODUCTION: Programmed death-ligand 1 (PD-L1) expression is used for treatment prediction in non-small cell lung cancer (NSCLC). While cytology may be the only available material in the routine clinical setting, testing in clinical trials has mainly been based on biopsies.METHODS: We included 2 retrospective cohorts of paired, concurrently sampled, cytological specimens and biopsies. Also, the l
This study evaluates the spatial and temporal performance of the Climate Hazard Group InfraRed Precipitation Satellite (CHIRPS) against Tropical Rainfall Measuring Mission (TRMM) Multi-Satellite Precipitation Analysis (TMPA) 3B42/3B43 v. 7 and Global Precipitation Measurement (GPM)-based Integrated Multi-Satellite Retrievals for GPM (IMERG V06), from 2000 to 2013. Several statistical metrics were
The simulation model which examines the dynamic behavior of real structures needs to address the impact of uncertainty in both geometry and material parameters. This article investigates three-dimensional finite element models for structural dynamics problems with respect to both model and parameter uncertainties. The parameter uncertainties are determined via laboratory measurements on several be
Spectral information obtained from induced polarization (IP) measurements can be used in a variety of applications and is often gathered in frequency domain (FD) at the laboratory scale. In contrast, field IP measurements are mostly done in time domain (TD). Theoretically, the spectral content from both domains should be similar. In practice, they are often different, mainly due to instrumental res
Background and purpose - Knowing how to interpret values obtained with patient reported outcome measures (PROMs) is essential. We estimated the substantial clinical benefit (SCB) and patient acceptable symptom state (PASS) for Forgotten Joint Score 12 (FJS) and explored differences depending on methods used for the estimates. Patients and methods - The study was based on 195 knee arthroplasties (K
Ultra-high-frequency ultrasound (UHFUS) has a reported potential to differentiate between aganglionic and ganglionic bowel wall, referred to as histoanatomical differences. A good correlation between histoanatomy and UHFUS of the bowel wall has been proven. In order to perform more precise and objective histoanatomical morphometrics, the main research objective of this study was to develop a compu
This paper introduces a low-complexity ultra-wideband quasi-deterministic ray tracing (QD-RT) method for statistical analysis of wireless channels. This model uses a statistical distribution to model the bistatic radar-cross-section (RCS) of irregular objects such as cars and pedestrians, instead of a deterministic propagation model, i.e., applying the exact values of bistatic RCSs. It is shown th
Collaboration across disciplines and stakeholders is important in handling complex societal problems. Even if collaborating is acknowledged as contributing towards societal change and innovation, collaborators’ emotional experiences during development, consolidation and completion of a given project are underexplored. This article discusses emotional labour in three cross-sectoral collaborations u
Myocardial infarction is a leading cause of death globally but is notoriously difficult to predict. We aimed to identify biomarkers of an imminent first myocardial infarction and design relevant prediction models. Here, we constructed a new case–cohort consortium of 2,018 persons without prior cardiovascular disease from six European cohorts, among whom 420 developed a first myocardial infarction
Human impacts on the natural world often generate environmental trends that can have detrimental effects on distributions of phenotypic traits. We do not have a good understanding of how deteriorating environments might impact evolutionary trajectories across multiple generations, even though effects of environmental trends are often significant in the statistical quantitative genetic analyses of
The three leading modes of the North Atlantic atmospheric circulation explain about 70% of the winter climate variability. Although climate models generally can capture these modes, biases may induce large uncertainties in regional climate predictions. Here, we evaluate the leading winter modes simulated by CMIP5-PMIP3 and CMIP6-PMIP4 models from the last millennium to future scenarios in comparis
The base (BOP) and the top (TOP) of the world income pyramid represent the poor people and the people from developed countries, respectively. About two-fifths of the world population can be categorized as poor. Poverty is a trap because children born to poor parents are likely to grow up to be poor adults. In recent years, a poverty reduction approach that combines business development with povert
This thesis consists of four papers studying image concerns in three unique settings. The first paper develops a model incorporating self-image into the buyer's utility in a ''Pay-What-You-Want'' (PWYW) pricing scheme. We introduce heterogeneity in consumption utility and image-sensitivity, generating different purchase decisions and optimal prices across individuals. When a good's fixed price is
We present a theoretical study of the absorption of light in periodic arrays of InP nanowires. The absorption in the array depends strongly on the diameter and the length of the nanowires, as well as the period of the array. Nanowires of a length of just 2 Am are able, after an appropriate choice for the other parameters, to absorb more than 90% of the incident energy of TE and TM polarized light,
The aging of the population is a worldwide trend, especially in Western countries. The increased number of people living past 65 years is also a trend for polypharmacy (the multiple use of medication) among elderly people. In terms of market orientation, the pharmaceutical industry is well-developed, but the same cannot be said in terms of design orientation. Previous studies indicate that packagi
Popular Abstract in Swedish Två händelser i tumörutvecklingen för en tumörcell är att erhålla okontrollerad celltillväxt och invasiva egenskaper. Detta tillåter tumöran att växa in i den omkringliggande vävnaden. I denna avhandling har vi specifikt studerat p16 och ERK1/2 med speciell fokus på förhållandet mellan invasion och proliferation i hudcancer och bröstcancer. Basalcellscancer har ett disTwo key events in the oncogenic process of tumor cells are to acquire uncontrolled proliferation and invasive properties. This allows the tumor to grow and invade beyond the tissue from which the tumor cells originate. We here specifically studied p16 and ERK1/2 with special focus on and the relation to proliferation and invasion in non-melanoma skin cancer and in breast cancer. In a model system
Northern Europe was capped by ice during Weichsel (Wurm), the maximum of which occurred approximately 18,000 years before present. When in the latter part of the 19(th) century the view of an all-devastating land ice (the tabula rasa hypothesis) was generally adopted by natural scientists, plant biogeographers used a simple model predicting a post-glacial, northwards re-migration of species in con
