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Background: The distribution of ovarian tumour characteristics differs between germline BRCA1 and BRCA2 pathogenic variant carriers and non-carriers. In this study, we assessed the utility of ovarian tumour characteristics as predictors of BRCA1 and BRCA2 variant pathogenicity, for application using the American College of Medical Genetics and the Association for Molecular Pathology (ACMG/AMP) var
In health care, the provision of pertinent information to patients is not just a moral imperative but also a legal obligation, often articulated through the lens of obtaining informed consent. Codes of medical ethics and many national laws mandate the disclosure of basic information about diagnosis, prognosis, and treatment alternatives. However, within publicly funded health care systems, other k
3D bioprinting has the potential to provide a unified framework for the manufacturing of tissue models for biomedical research, including drug discovery, disease modeling, and regenerative medicine. However, it remains challenging to 3D print replicas of human tissues that have accurate cell types, cellular densities, extracellular matrix compositions, and that can be assayed in a minimally invasi
Introduction: While it is recognized that there are costs associated with postoperative patient follow-up, risk assessments of catastrophic health expenditures (CHEs) due to surgery in sub-Saharan Africa rarely include expenses after discharge. We describe patient-level costs for cesarean section (c-section) and follow-up care up to postoperative day (POD) 30 and evaluate the contribution of follo
Many hand-held or mixed reality devices are used with a single sensor for 3D reconstruction, although they often comprise multiple sensors. Multi-sensor depth fusion is able to substantially improve the robustness and accuracy of 3D reconstruction methods, but existing techniques are not robust enough to handle sensors which operate with diverse value ranges as well as noise and outlier statistics
Pelvic floor reconstructive surgery (PFRS) has suffered from high recurrence rates ever since its birth. Implants were thus quickly employed, initially autologous grafts and allografts. Technological development led to the manufacturing of synthetic implants that were believed to provide the support needed during urinary incontinence and pelvic organ prolapse (POP) surgery. However, due to a surge
Background Celiac disease has an increasing incidence worldwide and is treated with lifelong adherence to a gluten-free diet. We aimed to describe gluten-free diet adherence rates in children with screening-identified celiac disease, determine adherence-related factors, and compare adherence to food records in a multinational prospective birth cohort study. Methods Children in The Environmental De
Introduction: The specificity of cortisol after 1 mg dexamethasone (cortisolDST) ≥50 nmol/L as a criterion for mild autonomous cortisol secretion (MACS) is approximately 85% in patients with adrenal incidentalomas (AI). The aim was to study the associations of cortisolDST to age, BMI, and renal function. Methods: We studied 1,129 patients with AI examined from 2005 to 2015 at Skåne University Hosp
Despite being the leading cause of death worldwide, cancer still lacks precise biomarkers for effective targeting, limiting efforts to reduce mortality rates. This review explores the role and clinical significance of a newly identified long non-coding RNA, MYOSLID, in cancer progression. MYOSLID has emerged as a critical modulator in cancer progression by influencing key hallmarks such as prolife
IMPORTANCE: Repeating a prostate-specific antigen (PSA) test after an elevated measurement is a guideline-recommended component of the prebiopsy workup. However, it is unclear whether certain patients can be exempted from repeat PSA testing and proceed directly to further workup.OBJECTIVE: To determine yearly PSA variability and implications of repeating an elevated PSA in the Prostate, Lung, Colo
Black carbon (BC) is produced by incomplete combustion of biomass and fossil fuels and is released as aerosols to the atmosphere with effects on the climate, environment, and human health. Current BC emissions are well monitored in many parts of the world. However, the geographical coverage is limited, and historical records of BC accumulation are still scarce. Here we present a quantification of
Vacuum membrane distillation is a promising technology for seawater desalination, as it enables high recovery ratios, with reasonable thermal and minimal electric consumption. Ceramic membranes can offer notable advantages over polymeric membranes, mainly due to their robust thermal and mechanical stability, yet they have limited representation in the literature. Accordingly, this work investigate
Background: Osteoarthritis (OA) and inflammatory arthritis (IA), including rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondylarthritis (axSpA), are leading causes of disability worldwide, significantly impacting health and quality of life. Sleep issues are highly prevalent in these populations, exacerbating pain, fatigue, and disease activity. However, there is a dearth of evi
microRNAs are small RNA molecules that can repress the expression of protein-coding genes post-transcriptionally. Previous studies have shown that microRNAs can also have alternative functions, including influencing target expression variation and covariation, but these observations have been limited to a few microRNAs. Here we systematically study microRNA alternative functions in mouse embryonic
Background and objective: The impact of a smoking and alcohol cessation intervention on health-related quality of life (HRQoL) following radical cystectomy (RC) is unclear. This study aimed to evaluate the effect of a 6-wk perioperative smoking and/or alcohol cessation intervention on HRQoL. A secondary objective was to assess the difference in HRQoL between patients with more than two and those w
Purpose: High-risk colon cancer may benefit from preoperative chemotherapy (preCHT), but evidence on its short-term safety and outcome is limited. Population-based evidence before its incorporation into national guidelines is lacking. Methods: Patients with final weighted stage II–III colon cancer undergoing elective resection between 2007 and 2017 were identified in the Swedish Colorectal Cancer
En av de vanligaste frågorna som brukar ställas till astronomer är om det finns liv någon annanstans i universum. Vi har ännu inget enkelt svar. Framsteg mot ett svar på denna fråga görs lite i taget. Den här avhandlingen är ett av dessa steg.Min forskning är inriktad på atmosfärerna hos så kallade "ultra-hot Jupiters": planeter i Jupiters storlek som kretsar så nära sina stjärnor att de hettas upOne of the biggest questions people ask astronomers is whether life exists elsewhere in the universe. Unfortunately, we don’t yet have an answer. Instead, progress towards an answer comes in small, careful steps. This thesis is one of those steps.My research has focused on the atmospheres of "ultra-hot Jupiters": planets the size of Jupiter that orbit so close to their stars they are heated to tho
This book challenges earlier understandings of early modern dissertations as unimaginative academic exercises. It argues for their continuous importance in scholarly and scientific discourse, and describes the richness and diversity of their subjects and themes. The book contains a complete catalogue of the almost 20,000 Swedish dissertations defended in Uppsala, Lund and Åbo, 1600 to 1820. The ca
This article provides a step-by-step guideline for measuring and analyzing visual attention in 3D virtual reality (VR) environments based on eye-tracking data. We propose a solution to the challenges of obtaining relevant eye-tracking information in a dynamic 3D virtual environment and calculating interpretable indicators of learning and social behavior. With a method called "gaze-ray casting," we
