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Background: With advances in clinical genetic testing, associations between genetic neurodevelopmental disorders and parkinsonism are increasingly recognized. In this review, we aimed to provide a comprehensive overview of reports on parkinsonism in genetic neurodevelopmental disorders and summarize findings related to genetic diagnosis, clinical features and proposed disease mechanisms. Methods:
BACKGROUND: Recent advances in disease-modifying treatments highlight the need for accurately identifying individuals in early Alzheimer's disease (AD) stages and for monitoring of treatment effects. Plasma measurements of phosphorylated tau (p-tau) are a promising biomarker for AD, but different assays show varying diagnostic and prognostic accuracies. The objective of this study was to determine
This article questions certain assumptions on the intellectual history of modern Islam and on one of the most influential modern reform movements, the Salafiyya. By looking at the Sufi origins of one of the main Salafi reformers, it relativizes the notion of an inherent anti-Sufism of this reform movement. The article examines how Muhammad 'Abduh (1849-1905), the famous Egyptian reformer, conver
Nanosized spherical copper particle embedded on oxide matrix (Cunp-Cu2O/SiO2) is synthesized from a low cost chalcopyrite concentrate. The concentrate is reduced by hydrogen at 1323 K, followed by acid leaching to produce Cunp-Cu2O/SiO2. Powder X-ray diffraction confirms the formation of metallic copper as the principal phase along with oxides of silicon and copper. The weight fractions of Cu, SiO
Context. Under certain conditions, stellar radial velocities can be determined from astrometry, without any use of spectroscopy. This enables us to identify phenomena, other than the Doppler effect, that are displacing spectral lines. Aims. The change of stellar proper motions over time (perspective acceleration) is used to determine radial velocities from accurate astrometric data, which are now
PurposeTo determine the association between the occurrence of sporadic and periodic fetal heart rate accelerations during labor and acidemia at birth.Materials and methodsThis is a case–control study of fetal heart rate patterns from 364 neonates with acidemia at birth (cord blood pH ResultsDuring the first stage, ≥2 sporadic accelerations were present in 16% of cases and 78% of controls; OR for a
Minor Field Studies (MFS) är ett Sida-finansierat stipendieprogram som ger studenter möjlighet att genomföra fältstudier i länder där Sverige bedriver utvecklingssamarbete. Genvägar till sidans innehåll:Om stipendietSå ansöker duNär du har skickat in din ansökanOm du beviljas stipendium Ansökan är öppen 5–25 april Kontaktinformation Maria NilssonSektionen Globalt engagemangMFS [at] global [dot] l
https://www.lu.se/student/internationella-mojligheter/stipendier-studier-och-praktik-utomlands/minor-field-studies - 2026-05-30
The infrastructure for 3G has been under development in Sweden since late 2000. Following from the so called beauty contest four operators within three years were to build competing systems to cover 99,98 percent of the population by the end of 2003, giving the administrative system an extreme challenge. Issues widely debated has been the alleged hazardousness of the electromagnetic radiation from
Theoretical predictions for ionization energies of inner core electrons generally come out much more accurately by taking the difference between the total energies of two self-consistent Hartree-Fock calculations than by using Koopmans' theorem. For the outer core electrons, on the other hand, little or no improvement over Koopmans' theorem is obtained from a `ΔSCF method'. We show here that the
A hierarchical multi-scale model that couples a region of material described by discrete dislocation plasticity to a surrounding region described by conventional crystal plasticity is presented. The coupled model is aimed at capturing non-classical plasticity effects such as the long-range stresses associated with a density of geometrically necessary dislocations and source limited plasticity, whi
The overall aim of the present work was to reduce losses during product changes or during rinsing in continuous food processing, with particular attention to dairy plants. The concept of sensor fusion of common process instruments was implemented as a tool to monitor the milk and fat concentrations in a dairy processing line. Special interest was drawn to the dynamic processes such as start-up, r
The interest in modelling, analysis and optimisation of supply chain structures has increased in the last decade. Among the reasons are globalisation, a general speed-up of the rate of change in the business environment, the trend towards more outsourcing of activities, and the rapid development in IT. This development has caused more and more people to realise the benefits of supply chain managem
Objectives: Patients with SLE have an increased risk of comorbidities and impaired survival. We aimed to assess whether various thresholds of oral CS (OCS) can predict development of infections, comorbidities, malignancies and survival in SLE using data from national health registries in Sweden. Methods: All incident SLE cases, age >18 years, in Sweden (n ¼ 5309) between 2005 and 2020 and matched
Background: Most patients diagnosed with breast cancer present with a node-negative disease. Sentinel lymph node biopsy (SLNB) is routinely used for axillary staging, leaving patients with healthy axillary lymph nodes without therapeutic effects but at risk of morbidities from the intervention. Numerous studies have developed nodal status prediction models for noninvasive axillary staging using po
Targeted temperature management (TTM) may moderate the injury from out-of-hospital cardiac arrest. Slowing the metabolism has been a suggested effect. Nevertheless, studies have found higher lactate levels in patients cooled to 33°C compared with 36°C even days from TTM cessation. Larger studies have not been performed on the TTM's effect on the metabolome. Accordingly, to explore the effect of TT
Perioperative hyponatremia, due to non-osmotic release of the antidiuretic hormone arginine vasopressin, is a serious electrolyte disorder observed in connection with many types of surgery. Since blood loss during surgery contributes to the pathogenesis of hyponatremia, we explored the effect of bleeding on plasma sodium using a controlled hypotensive hemorrhage pig model. After 30-min baseline pe
High levels of ADAM17 activity have emerged as an important mediator in severe COVID-19. This study aims to characterize eventual causal relationships between ADAM17 and COVID-19. Using Mendelian randomization analyses, we examined the causal effects of circulating ADAM17 on COVID-19 outcomes using summary statistics from large, genome-wide association studies of ADAM17 (up to 35,559 individuals)
