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We investigated the intrinsic reactivity of CO on single-layer and multilayer PdO(101) grown on Pd(100) using temperature-programmed reaction spectroscopy (TPRS) and reflection absorption infrared spectroscopy (RAIRS) experiments, as well as density functional theory (DFT) calculations. We find that CO binds more strongly on multilayer than single-layer PdO(101) (∼119 kJ/mol vs 43 kJ/mol), and tha
Currently, FLT3 tyrosine kinase inhibitors (TKIs) are emerging as the most promising drug therapy to overcome the dismal prognosis of acute myelogenous leukemia (AML) patients harboring internal tandem duplications (ITDs) of FLT3. However, up-front drug resistance occurs in approximately 30% of patients, and molecular mechanisms of resistance are poorly understood. Here, we have uncovered a novel
In ischaemic hearts, endothelin (ET) levels are increased, and vasoconstrictor responses to ET-1 are greatly enhanced. We previously reported that ETB receptors are up-regulated in the smooth muscle layer of coronary arteries after myocardial ischaemia-reperfusion and that the MEK-ERK1/2 signalling pathway is involved in ETB receptor up-regulation. Whether ETs are directly involved in receptor reg
The role of temporal changes and spatial variability in predation risk and prey's means of mitigating such risks is poorly understood in the context of potential threats of global climate change for migratory birds. Yet nest predation, for example, represents a primary source of reproductive mortality in birds. To assess risk birds must spend time prospecting potential breeding sites for cues or s
Navigate PD was an educational program established to supplement existing guidelines and provide recommendations on the management of Parkinson's disease (PD) refractory to oral/transdermal therapies. It involved 103 experts from 13 countries overseen by an International Steering Committee (ISC) of 13 movement disorder specialists. The ISC identified 71 clinical questions important for device-aide
The combination of nanoparticles and polymers into nanocomposite gels has been shown to be a promising route to creating soft materials with new or improved properties. In the present work, we have made use of Laponite nanoparticles in combination with a poly(N-isopropylacrylamide) (PNIPAAM)polymer and describe a phenomenon taking place during the polymerization and gelling of this system. The pre
Objectives. To study the course of impairment measured by signals of functional impairment (SOFI) and disability measured by health assessment questionnaire (HAQ) over 20 years in rheumatoid arthritis (RA) patients followed from diagnosis. To explore the contribution of disease activity, joint damage and comorbidity to variation of SOFI and HAQ over time. Methods. RA patients diagnosed 1985-1989 w
Cloud simulations and cloud-climate feedbacks in the tropical and subtropical eastern Pacific region in 16 state-of-the-art coupled global climate models (GCMs) and in the International Pacific Research Center (IPRC) Regional Atmospheric Model (iRAM) are examined. The authors find that the simulation of the present-day mean cloud climatology for this region in the GCMs is very poor and that the cl
The splice variant INS-IGF2 entails the preproinsulin signal peptide, the insulin B-chain, eight amino acids of the C-peptide and 138 unique amino acids from an ORF in the IGF2 gene. The aim was to determine whether levels of specific INS-IGF2 autoantibodies (INS-IGF2A) were related to age at diagnosis, islet autoantibodies, HLA-DQ, or both, in newly diagnosed type 1 diabetes patients and controls
d-dimer testing is widely used as part of the diagnostic algorithm for the exclusion of deep vein thrombosis (DVT) but is considered of limited in value for ruling DVT in. Since d-dimers are poorly defined, there is no standardization of the assays and this makes reliable comparisons between clinical studies difficult. We report on a performance evaluation of a new marker of activated coagulation
This study constitutes a preliminary survey within the project "Lake and groundwater paleohydrology of the Vomb plain, southern Sweden, for quantitative paleoclimatic calibration". The aim of the study is to describe the Holocene sediment stratigraphy of the former lakes Fönesjön and Kalvsjön (Kalvs mosse), and furthermore to describe and date stratgraphical indications of climatically c
Corporate cash holdings have an important role in the financial management of corporations. Firms hold cash for various reasons, Keynes (1936) states the reasons to be of transaction, precautionary and speculative nature, respectively, and firms’ cash policies differ both on an industry and firm level. Previous empirical studies mainly deal with the determinants and behavior of corporate cash hold
En produkts formgivning är avgörande för hur eftertraktad den blir på marknaden, något som resulterat i att stora resurser läggs ner på att ge pro-dukter ett så tilltalande yttre som möjligt. För att investerade resurser inte ska gå om intet är det viktigt att skydda formgivningen på ett adekvat sätt, vilket t.ex. kan göras med hjälp av olika, till viss del överlappande, im-materialrättsliga skyddA product's design is crucial to how popular it will become on the market. This has resulted in that significant resources are laid down to give products an exterior as attractive as possible. To make sure that the spent resources should not be wrecked, it is important to protect the design adequately. This can e.g. be done by different, partially overlapping, kinds of intellectual property pr
The European Spallation Source (sv: Europeiska Spallationskällan) kommer att bli den mest kraftfulla spallationskällan i världen när den är i drift vid full kapacitet. Neutronerna som används av vetenskapsmän och ingenjörer är spallerade från ett roterande hjul av volfram, som blir bombarderat av accellererade protoner. Hjulet, även kallat målet, upplever värmeutveckling under spallationsprocessenThe European Spallation Source (ESS) is going to be the worlds most powerful spallation source once in full operation. The neutrons used by scientists and engineers are spallated from a rotating wheel of wolfram, being bombarded by accellerated protons. The wheel, also called the target, develops heat in the process, and is therefore cooled by a helium cooling system. The target primary cooling sy
Den lågt liggande önationen Maldiverna är utsatt för stigande havsnivå och kusterosion. I studien genomförs en jämförande fallstudie som undersöker hur nationella, regionala och lokala myndigheter arbetar för att minska risken och klimatanpassa för kusterosion på två lokalbefolkningsöar och en turistö i Laamu-atollen i Maldiverna. Syftet med studien är att undersöka om myndigheternas riskreducerin
Hur ofta händer det att du inte slänger ditt avfall på rätt plats? Avfallshierarkin uppmuntrar godare resurshållning och genom att följa dess principer kan goda förutsättningar för att förebygga uppkomsten av avfall erhållas. Människan värdesätter miljöarbetet olika och förhoppningarna är att avfallsfrågan ska tas på ännu större allvar. Efterfrågan av biogas och fjärrvärme är större än mängden suIt is very important to understand that the amount of food waste and biomass discarded separately has a direct impact on how much biogas can be produced. E.ON Gas is an energy company with ambitions to live by the current framework for waste management which consist of five-step hierarchy where the waste treatment is ordered in a way that surveys the environment. The waste management hierarchy sta
För närvarande finns ett välutvecklat skatteavtalsnätverk med över 3000 tecknade avtal. Med detta följer också stora möjligheter till internationell skatteplanering. Treaty shopping är inget nytt fenomen inom internationell skatterätt men har aldrig varit lika kontroversiellt som nu. Treaty shopping innebär att en skattskyldig organiserar sina affärer i syfte att omfattas av ett visst skatteavtaThere is currently a well-developed tax treaty network with over 3000 concluded treaties. Accordingly, there are countless opportunities for international tax planning. The concept of treaty shopping is a fairly new phenomenon and it has never been as controversial as today. Treaty shopping implies that taxpayers arrange their affairs in order to be covered by a particular tax treaty. To be cove
Introduction: The Hippo signaling pathway is a key regulator of cellular growth and organ size, acting through the transcriptional coactivators YAP and TAZ. These proteins shuttle between the nucleus and cytoplasm in response to Hippo pathway activity, which, when active, leads to cytoplasmic sequestration and degradation of YAP/TAZ, preventing them from initiating gene transcription. Although ini
Uppsatsen som har författats behandlar våld mot tjänsteman med särskilt fokus på vilken betydelse kroppskamerabevisning har i tillämpningen av lagrummet. Syftet är att analysera hur våld mot tjänsteman ska förstås och vidare se prov på hur kroppskamera påverkar domstolarnas bedömning av händelseförloppet i praktiken. Arbetet kombinerar ett rättsdogmatiskt arbetssätt med en empirisk undersökning avThis thesis examines the offence of violence against a public official, with a particular focus on the role of body-worn camera evidence in the application of the law. The purpose of the thesis is to analyse how violence against a public official should be understood and to examine how body-worn cameras affect the courts’ assessment of events in practice. The study combines a legal analysis with a
