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Deregulation of the phosphatidylinositol 3-kinase (PI3K) pathway either through loss of PTEN or mutation of the catalytic subunit alpha of PI3K (PIK3CA) occurs frequently in human cancer. We identified PIK3CA mutations in 26% of 342 human breast tumor samples and cell lines at about equal frequency in tumor stages I to IV. To investigate the relationship between PTEN and PIK3CA, we generated a coh
We prospectively investigated anti-Müllerian hormone (AMH) as a measure of ovarian insult in young females during and after treatment for Wilms tumor (WT), osteosarcoma (OS), and Ewing sarcoma (ES). Twenty-one female childhood cancer patients, with a mean age of 7.9 years (range 0.6-17), entered the study. Levels of AMH, follicle-stimulating hormone (FSH), and luteinizing hormone were monitored at
Background and aim: Migraine often includes co-existing tension-type headache (TTH) and neck pain (NP). Multiple headache questionnaires assessing headache impact have been described previously; however, none of the existing questionnaires have been designed to cover migraine with co-existing TTH and NP. Therefore a new questionnaire was developed to measure these co-morbidities. The aim was to de
BACKGROUND AND AIMS: Prospective and population-based studies on the incidence of acute pancreatitis (AP) are lacking. Alcohol consumption has increased considerably in Iceland during the last decade. We aimed to determine the incidence, etiology, severity, and complications of AP and compare the results with a previous study on AP in Iceland.METHODS: A prospective population-based study of patien
Hyperinsulinemia is an adaptive mechanism that enables the maintenance of normoglycemia in the presence of insulin resistance. We assessed whether glucagon is also involved in the adaptation to insulin resistance. A total of 1,437 individuals underwent an oral glucose tolerance test with measurements of circulating glucose, insulin, and glucagon concentrations at 0, 30 and 120 min. Early glucagon
This thesis makes a contribution to systemic risk literature in the European banking system. The intimate interdependence between the European banking industries and the fragile GIIPS debt market has jeopardized the banking sector in Europe. The threats of unfavourable financial conditions in European bank- ing sufficiently highlight the importance of the dissertation’s distinct focus on systemic
Physical Geography and Ecosystems Analysis NGEN08 Remote sensing NGEM01 Master Thesis Project NGEN01 Climate change Year 1 Year 2 • Focus: broad or specialised – for options please contact study advisor • NOTE: A MSc from INES requires ONLY 45 credits INES courses • Main subjects: Environmental and Climate Science, Ecosystems Analysis, Biogeophysics, Methods in Environmental Analysis, GIS and Remo
Microplastic (MP) pollution is increasingly recognized as a critical issue in coastal environments, where complex interactions between ocean currents, winds, waves, and human activities govern the transport and deposition of synthetic particles. Although previous studies in Asia have documented MPs accumulation linked to riverine discharge, tourism pressures, and monsoonal circulation, limited wor
cut-open-cut February 2025, March 2024 Using transversal video as a tool for exploring transmodal remediationDuring this spring clarinettist Robert Ek will explore embodied music cognition from two directions with composer Kent Olofsson and choreographer Lidia Wos in several labs at IAC. Embodied music cognition describes how our body is a natural mediator of musical events, meaning that we simply
https://www.iac.lu.se/research/visiting-researchers/robert-ek - 2026-07-07
Roundtable. Friday 11 March, 15:00-17:00 (CET) Digital roundtable co-organised by Valentina Gamberi (Junior Fellow at the Research Centre for Material Culture at Leiden, the Netherlands) and Paulina Kolata (Postdoctoral Fellow at the Centre for East and Southeast Asian Studies at Lund, Sweden). In the era of growing concerns over waste and pollution produced in our lives, several scholars of all t
https://www.ace.lu.se/activities/invisibility-sacred-waste-asian-perspectives - 2026-07-07
Inform your students: Date and time The date and time of the exam must be clearly stated, it is extra important that the exam starts at the time you have specified in the information you have given to the students. If they need to register for the exam, where they can register and when is the last date for registration. Tools & software Which digital tools will be used and how they will find their
We are redesigning the Spice and Medicinal Garden! In 2026 and 2027, visitors will be able to watch a new medicinal plant garden take shape just west of the greenhouse, and the old area will be closed down. In this part of the garden you can find herbs that have been used by humans for a long time. Deadly poisonous plants, witchcraft plants and daily culinary herbs are grown side by side. But al
https://www.botan.lu.se/en/garden-and-plants/plants-outdoors/spice-and-medicinal-garden - 2026-07-07
Back pain is the #1 cause of years lived with disability worldwide, yet surprisingly little is known regarding the biology underlying this symptom. We conducted a genome-wide association study (GWAS) meta-analysis of chronic back pain (CBP). Adults of European ancestry were included from 15 cohorts in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and from th
Motivation: Dynamical models describing intracellular phenomena are increasing in size and complexity as more information is obtained from experiments. These models are often over-parameterized with respect to the quantitative data used for parameter estimation, resulting in uncertainty in the individual parameter estimates as well as in the predictions made from the model. Here we combine Bayesia
Avian haemosporidians are vector-transmitted blood parasites that are distributed worldwide, abundant in many bird families and well studied across Europe and North America. Since avian haemosporidians have been poorly examined in the Palearctic migratory flyways of the Western Balkans, the goal of this study was to investigate which species of three haemosporidian genera, Plasmodium, Haemoproteus
The secondary injury cascades exacerbating the initial brain injury following intracerebral haemorrhage (ICH) are incompletely understood. We used dual microdialysis (MD) catheters placed in the perihaemorrhagic zone (PHZ) and in seemingly normal cortex (SNX) at time of surgical ICH evacuation in ten patients (range 26-70 years). Routine interstitial MD markers (including glucose and the lactate/p
