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Mammalian dihydroorotate dehydrogenase, the fourth enzyme of pyrimidine de novo synthesis is an integral protein of the inner mitochondrial membrane that faces the intermembrane space and is functionally connected to the respiratory chain via ubiquinone. Here, we describe the first cloning and analyzing of the complete cDNA of mouse dihydroorotate dehydrogenase. Based on our recent functional expr
Background and purpose: Substantial inter-observer variations in target delineation have been presented previously. Target delineation for paediatric cases is difficult due to the small number of children, the variation in paediatric targets, the number of study protocols, and the individual patient's specific needs and demands. Uncertainties in target delineation might lead to under-dosage or ove
The novel coronavirus SARS-CoV-2 (COVID-19) has spread globally in a short period of time and quickly developed into a pandemic. In connection with its progress, entire cities and countries have been closed down, people are quarantined, and infrastructure and trade have been suspended. As this is a new virus, no vaccine or antiviral drugs are available, but instead non-medical measures such as soc
Objective: Antimicrobial resistance is a growing worldwide problem and is considered to be one of the biggest threats to global health by the World Health Organization. Insights into the determinants of antibiotic prescribing may be gained by comparing the antibiotic usage patterns of Australia and Sweden. Design: Publicly available data on dispensed use of antibiotics in Australia and Sweden betw
Introduction: Venous thromboembolism (VTE) and cardiovascular disease (CVD) share some risk factors such as smoking, obesity, and dietary habits. Poor self-rated health (SRH) has been shown to be a predictor of arterial CVD and mortality for both men and women. The association between SRH and VTE has only been investigated in one previous Swedish study with a cohort that just contained women. This
The paper follows the development of the tourism industry in a small, traditional mining town in northern Sweden. It highlights local agency in the diversification process, as well as interpath relations between tourism and mining. Drawing on 21 semi-structured interviews, the paper finds that the two seemingly unrelated paths share the need for a variety of local endowments and in so the dominant
OBJECTIVES: To explore whether smoking and alcohol use are associated with hand osteoarthritis (OA) features in two different OA cohorts.METHOD: We studied 530 people with radiographic hand OA from the Musculoskeletal pain in Ullensaker STudy (MUST) and 187 people from the Oslo hand OA cohort [mean (sd) age 65 (8.0) and 62 (5.7) years, 71% and 91% women, respectively]. Smoking, alcohol use and han
Programming languages are ever evolving, with new languages being invented to solve new problems, and old languages being extended to solve old problems in new ways. With the continued evolution of programming languages, and with new and improved static program analyses, we need flexible systems for building our static analyses and compilers. Declarative programming with Reference Attribute Gramma
Introduction: There is no definitive cure for Dupuytren disease (DD), and recurrence of finger contractures after treatment is common. Surgical fasciectomy is considered the standard treatment method for recurrence, although associated with a high incidence of complications. Collagenase injection, a non-surgical treatment option, has been shown to be a safe and effective method; however, most stud
Background: Home care service (HCS) for sick children is a complex healthcare service, which can be organised in various models. Despite the possibility to support family everyday life, the accessibility and utilisation may still be limited. The aim of this study was to (i) determine characteristics in referrals to county-based HCS, (ii) determine characteristics of referred children and (iii) ass
Objectives: The insertion of grommets is one of the most commonly performed surgical procedures in children. The underlying reason might be otitis media with effusion (OME) with concomitant hearing loss, recurrent acute otitis media (rAOM) or a combination of the two. Sweden has a national quality register for children receiving grommets with the purpose of evaluating how treatment guidelines are
Summary: In community dwelling, 75-year-old women followed 10 years, a frailty index was created at each of three visits. Frailty score increased by ~ 6–7% annually. A higher frailty score was equivalent to being 5–10 years chronologically older. Frailty was associated with low bone density and higher risk of dying. Introduction: To understand the distribution of frailty among a population-based s
Combining neo-institutionalism, actor network theory, and Gabriel Tarde’s sociology, Czarniawska considers the key driver of organizational change to be imitation but an imitation that rests on translation. Organizations emulate one another by translating fashionable ideas according to their understanding, traditions, needs, and means. As translation in this tradition always entails a transformati
Authors: Emma Nilsson and Emma Silverberg Title: People in a crisis are not able to work with change Supervisor: Helene Hansen Assessor: Mikael Sandgren The aim of this study was to examine social workers reasoning on social services support to parents of children placed in compulsory care. This study was based on the Swedish social services law, 6:7 Socialtjänstlagen, that describes that parents
The purpose of the study is to investigate social workers' perspectives on and experiences of mental illness among children aged 0 - 12. The study is based on a qualitative method with semi-structured interviews and thematic analysis. The theoretical perspectives are attachment theory and mentalization. Results and analysis are presented thematically with anchoring in relevant theory and resea
Syftet med denna framställning är att genom en rättsdogmatisk och rättssociologisk metod begrunda och skapa en bättre förståelse för lagstiftarens val att särbehandla unga lagöverträdare. Med gällande rätt, dess historiska bakgrund, straffets funktion och myndighetsbegreppet i åtanke har särbehandlingen diskuterats i förhållande till begreppet rättvisa. Vid femton års ålder inträder straffansvar The purpose of this presentation is to create a better understanding of the Swedish legislation treating young offenders differently in comparison to adult offenders. With current legislation, its historical background, penalty function and the age of majority in mind, the differential treatment will be discussed in relation to the concept of justice. At the age of fifteen, the young individual be
Author: Mimmi Dunfjäll Title: Identities, roles and norms – a discourse analysis of gender and sexuality in practical social work with young citizens and families [translated title] Supervisor: Gabriella Scaramuzzino The aim of this study is to examine how normative male and female identities are constructed in social work practice, specifically with young citizens and families, and also to identi
