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This book analyses the way in which international human rights law (IHRL) and international investment law (IIL) are deployed – or fail to be deployed – in conflict countries within the context of natural resources extraction. It specifically analyses the way in which IIL protections impact on the parallel protection of economic, social and cultural rights (ESC rights) in the host state, especiall

Knowing whether a software feature will be completed in its planned iteration can help with release planning decisions. However, existing research has focused on predictions of only low-level software tasks, like bug fixes. In this paper, we describe a mixed-method empirical study on three large IBM projects. We investigated the types of iteration changes that occur. We show that up to 54% of high

Universal Design (UD) is usually stated to be “for all ages and abilities”. Given that stroke is a major source of disability, it is important that UD recommendations take stroke-specific problems into account. Within the framework of EU project STARR, we have investigated user requirements of stroke survivors. In this project we have used a mix of interviews, focus groups, design workshops and te

Renin from plasma, kidney, and recombinant sources was previously demonstrated to cleave C3 to C3a and C3b. C3a was generated at a similar rate to that by C3 convertase, and C3 cleavage was inhibited by the renin inhibitor aliskiren. Renin endogenously produced by Calu6 cells also led to C3 deposition on cells. These results have been challenged by another group suggesting that recombinant renin d

Human DNA polymerase λ is an intermediate fidelity member of the X family, which plays a role in DNA repair. Recent X-ray diffraction structures of a ternary complex of a loop-deletion mutant of polymerase λ, a deoxyguanosine triphosphate analogue, and a gapped DNA show that guanine and thymine form a mutagenic mispair with an unexpected Watson-Crick-like geometry rather than a wobble geometry. He

Half of parents to infants and toddlers experience unwanted intrusive thoughts (UITs) about intentionally harming their child. For some, this can lead to impaired parental self-efficacy, elevated parental stress, and symptoms of depression. Many do not disclose their thoughts due to shame. Our research group has developed a self-guided online cognitive intervention for parents with distressing UIT

ER-positive/HER2-negative (ERpHER2n) breast cancer classified as PAM50 HER2-enriched (ERpHER2n-HER2E) represents a small high-risk patient subgroup. In this study, we investigate genomic, transcriptomic, and clinical features of ERpHER2n-HER2E breast tumors using two primary ERpHER2n cohorts comprising a total of 5640 patients. We show that ERpHER2n-HER2E tumors exhibit aggressive clinical feature

Rhythmicity is a composite competence that spans perceptual, motor, and socio-cognitive abilities. This is highly salient when adopting a developmental perspective, as we do in this chapter that reviews data from humans and other singing primate taxa with a close (gibbons) or remote (indri lemurs) phylogenetic relatedness to our species. The findings we review show that rhythmicity develops as an

The evolutionary biologist Julian Huxley (1887–1975) attempted to promote a “religion for the future,” which he would come to refer to as Transhumanism. Transhumanism was an attempt to unite a more traditional humanistic view of the human as containing some form of core essence or potential with an evolutionary point of view of humans as a work in progress. Before humans, natural selection had bee

Dyspnea is a common and highly distressing symptom in patients with advanced illnesses. Many patients continue to experience chronic dyspnea despite optimal management of underlying disease(s) and various non-pharmacologic interventions, necessitating the consideration of pharmacologic therapies for palliation of dyspnea. One commonly asked question by clinicians is whether benzodiazepines have a

Why do some genomes stay small and simple, while others become huge, and why are some genomes more stable? In contrast to angiosperms and gymnosperms, liverworts are characterized by small genomes with low variation in size and conserved chromosome numbers. We quantified genome evolution among five Marchantiophyta (liverworts), measuring gene characteristics, transposable element (TE) landscape, c

Catalytic studies traditionally rely on steady-state conditions resulting in time-averaged datasets that do not differentiate between active and spectator species. This limitation can cause misinterpretations of catalytic function, as the signal of short-lived intermediates responsible for producing desired reaction products is often masked by more intense spectator species. Time-resolved ambient

Abstract in French:Cette recherche s'intéresse à la mobilisation transnationale de la diaspora autour du vote externe et à l'implication des organisations diasporiques dans le processus électoral du pays d'origine. Plusieurs approches expliquent la transnationalisation politique des groupes diasporiques ; cependant, elles ne parviennent pas à clarifier (1) comment certains moments historiques (parThis research is concerned with transnational diaspora mobilisation around external voting and diaspora organisations’ involvement in the homeland electoral process. There are several approaches that explain the political transnationalisation of the diasporic groups; yet, they fail to clarify (1) how some historical moments (e.g., extending the voting right to non-resident nationals) can generate

Nitrogen and sulfur are key elements in the biogeochemical cycles of marine ecosystems to which benthic foraminifera contribute significantly. Yet, cell-specific assimilation of ammonium, nitrate and sulfate by these protists is poorly characterized and understood across their wide range of species-specific trophic strategies. For example, detailed knowledge about ammonium and sulfate assimilation

Calling has gained importance in the career and organization scholarship as a key concept to better explain the meaningfulness of work from a humanistic perspective. On the contrary, much debate remains about the ways a calling–and the meaningfulness intertwined with it–can transform over time. To respond to this problem in the literature, we investigate the calling of corporate social responsibil

We investigate the role of the coupling between a spin-orbit coupled semiconductor nanowire and a conventional s-wave superconductor on the emergence of the topological superconducting phase with Majorana bound states in an applied magnetic field. We show that when the coupling is strong, the topological phase transition point is very sensitive to the size of the superconductor and in order to rea

The West Atlantic trumpetfish (Aulostomus maculatus) performs an unusual hunting strategy, termed shadowing, whereby a trumpetfish swims closely behind or next to another ‘host’ species to facilitate the capture of prey. Despite trumpetfish being observed throughout the Caribbean, observations of this behaviour appear to be concentrated to a handful of localities. Here we assess the degree of geog

This research aims at assessing the role of the affective and sensory dimension of space in the communicative constitution of a touristic strategy. Lately scholarly attention has been drawn to the constitutive relation between strategic communication and space (Cassinger & Thelander 2022). Following especially the work of Lefebvre on the production of space (1991), these studies investigate ho

Given a sensor network, TDOA self-calibration aims at simultaneously estimating the positions of receivers and transmitters, and transmitters time offsets. This can be formulated as a system of polynomial equations. Due to the elevated number of unknowns and the nonlinearity of the problem, obtaining an accurate solution efficiently is nontrivial. Previous work has shown that iterative algorithms

Hybridization is increasingly recognized as an important evolutionary force. Novel genetic methods now enable us to address how the genomes of parental species are combined in hybrid lineages. However, we still do not know the relative importance of admixed proportions, genome architecture and local selection in shaping hybrid genomes. Here, we take advantage of the genetically divergent island po