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In recent years, the prevalence of idiopathic pulmonary fibrosis (IPF) and post-COVID-19 pulmonary fibrosis has risen. Nevertheless, effective diagnostic and prognostic biomarkers alongside targeted treatments are lacking, making lung transplantation the last resort for many patients with end-stage disease. However, bronchiolitis obliterans syndrome (BOS), a manifestation of chronic lung allograft

Rationale: Atrial fibrillation causes one-fifth of ischemic strokes, with a high risk of early recurrence. Although long-term anticoagulation is highly effective for stroke prevention in atrial fibrillation, initiation after stroke is usually delayed by concerns over intracranial hemorrhage risk. Direct oral anticoagulants offer a significantly lower risk of intracranial hemorrhage than other anti

Water scarcity poses a major obstacle to sustainable development, and precise discharge prediction plays a vital role in enabling effective water resource management. This study investigated improved prediction techniques for nonstationary time series. The study evaluated the effect of signal processing techniques and blending approaches on the performance of deep learning models for daily dischar

Objective: Obstetric anal sphincter injuries (OASIS) are severe complications to vaginal births with potential long-term consequences. Maternal origin has been proposed to affect the overall risk, but the association and underlying explanation are uncertain. The objective was to assess the association between maternal country of birth and OASIS. Methods: A Swedish nationwide cohort study including

Summary: Frailty reflects an accelerated health decline. Frailty is a consequence of fracture and contributes to fracture. Greater frailty was associated with higher fracture risk. Frail women were at immediate risk (within 24 months) of a hip or major fracture. Fracture prevention could be improved by considering frailty status. Introduction: Frailty encompasses the functional decline in multiple

In-cycle closed-loop combustion control has been proved to reduce cycle-to-cycle variations on emissions and indicated thermal efficiency. In this paper, the in-cycle closed-loop combustion con-trollability achieved by a pilot-main fuel injection scheme is investigated. The controllability is studied by means of the maximum reachable indicated thermal efficiency (MRE). A combustion model is used f

During the course of the late nineteenth and early twentieth centuries, conditions for life in the city changed drastically. Investments in infrastructure, health and education coincided with economic growth, urbanisation and mortality decline. This dissertation uses newly available macro- and micro-level data to examine the consequences and mechanisms of an important investment in cities: the bui

Reconstitution of the tyrosyl radical in ribonucleotide reductase protein R2 requires oxidation of a diferrous site by oxygen. The reaction involves one externally supplied electron in addition to the three electrons provided by oxidation of the Tyr-122 side chain and formation of the μ-oxo- bridged diferric site. Reconstitution of R2 protein Y122F, lacking the internal pathway involving Tyr-122,

Introduction: Traditionally, the academic librarian has served as an information specialist working in close professional contact with researchers to provide support in the process of scientific investigation. When the Internet entered the academic world, the belief emerged that researchers could handle information on their own. Thus, the value of personal professional interaction between the acad

There has been an upsurge of interest in the principle of extended producer responsibility (EPR) among policy makers and scholars in non-OECD countries. The principle has been applied and its impacts studied rather extensively in various OECD countries. However, similar experiences are largely lacking in non-OECD countries. This paper presents some ongoing research and preliminary findings on the

The extraordinary diversity of flowering plants has long captivated biologists andevolutionary ecologists. Plant-insect relationships are recognized as a major driverof this diversity, with pollinators playing a crucial role in angiosperm speciation andtrait diversification. Numerous observational and experimental studies have shownthat pollinators influence the evolution of floral traits—such as

BACKGROUND: Acute kidney injury (AKI) following cardiac surgery is a well-described phenomenon, usually associated with hemodynamic changes ultimately leading to ischemic injury to the kidneys. In this study, we assessed the occurrence of AKI in a cohort of patients undergoing elective cardiac surgery at a single center.METHODS: Patients undergoing elective cardiac surgery (coronary artery bypass

Background: Randomized trials have shown that axillary clearance (AC) can safely be omitted in patients with sentinel lymph node-positive breast cancer. At the same time, de-escalation of chemotherapy in postmenopausal patients with ER+HER2− breast cancer may depend on detailed axillary nodal stage. The aim of this pre-specified secondary analysis of the SENOMAC trial was to investigate whether th

Context. The TOI-178 system consists of a nearby late K-dwarf transited by six planets in the super-Earth to mini-Neptune regime, with radii ranging from -1.1 to 2.9 R and orbital periods between 1.9 and 20.7 days. All planets but the innermost one form a chain of Laplace resonances. Mass estimates derived from a preliminary radial velocity (RV) dataset suggest that the planetary densities do not

Introduction and Aims: Injecting opioid users are at elevated risk of death. Although liver disease (especially hepatitis C) is common, its impact on mortality is low in active injectors. Because opioid substitution therapy (OST) reduces the risk of death from directly drug related causes, we hypothesised that the proportion of liver-related deaths would increase in subjects receiving OST. We inve

BACKGROUND: There is no consensus whether angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) should be used for secondary prevention in all or in only high-risk patients after an acute myocardial infarction (AMI).OBJECTIVES: This study sought to investigate whether ACEI/ARB treatment after AMI is associated with better outcomes across different risk profiles, inc

Popular Abstract in Swedish Nanoteknik och nanotrådar omnämns ofta media idag, men vad är egentligen en nanotråd, och vad kan den användas till? Dagens datorer, lysdioder och solceller är till stor del beroende av halvledare. En halvledare är ett kristallint material där man enkelt kan ändra ledningsförmågan. Man kan dels bestämma ledningsförmågan när materialet tillverkas genom att tillföra ytter

In nonequimolar solutions of a cationic and an anionic surfactant, vesicles bearing a net charge can be spontaneously formed and apparently exist as thermodynamically stable aggregates. These vesicles can associate strongly with polymers in solution by means of hydrophobic and/or electrostatic interactions. In the current work, we have investigated the rheological and microstructural properties of

OBJECTIVE: Patients with extensive and long-standing ulcerative colitis have an increased risk of developing colorectal cancer and sub-epithelial fibrosis. The polypeptide transforming growth factor alpha (TGF-alpha) has mitogenic effects and it is believed that local overproduction may result in tumour formation and fibrosis. DESIGN: In the present study, we correlated the presence of TGF-alpha i