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This paper examined the language and content of the U.S. Forest Service's Serious Accident Investigation Guide (SAIG), which is used to investigate what the organization terms 'serious wildland fire accidents'. The purpose of research was to identify whether the language in the guide was objective, or if it biased the accident analysis process and conclusions of the accident report. Qu
Alzheimer's disease is a neurodegenerative disease that often affects the elderly and is accompanied by cognitive loss. The disease is characterized by the formation of amyloid beta (Aβ) plaques and Tau tangles in the brain, and microglia, the brain's resident immune cells, have been found to play a critical role in the progression of the disease. Recent studies suggest that microglia may
This study investigates the causal effect of environmental attitudes on number of children one has. The aim is to contribute to the recent discussion on reducing carbon emissions by having fewer children. Using data from the World Values Survey Association, an instrumental variables approach was used to analyse the research question. Moreover, a factor analysis was conducted in order to create a v
Kan kreatinmetabolismen vara ett potentiellt behandlingsmål för lungcancer i skivepitel? Lungcancer är en av världens vanligaste typer av cancer. Varje år rapporteras över 2 miljoner nya lungcancer fall och 1,8 miljoner dödsfall i världen enligt statistik från 2022. Cancer uppstår som en konsekvens av både arv och miljö. Den vanligaste orsaken till lungcancer är rökning. De två vanligaste typerLung cancer is one of the most common cancer types and the leading cause of cancer-related mortality. Squamous cell carcinoma (SqCC) of the lung is the second most common histological subtype of lung cancer and the most prevalent in smokers. It is aggressive and hard to treat due to a lack of identified driver mutations and unresponsiveness to treatment. Finding new targeted therapies for SqCC is
OBJECTIVES: Despite the recent introduction of new peroral drugs as well as neurosurgical methods for Parkinson's disease, treatment of late stage parkinsonian patients remains difficult and many patients become severely handicapped because of fluctuations in their motor status. Injections and infusions of apomorphine has been suggested as an alternative in the treatment of these patients, but the
This study was part of a Swedish interdisciplinary research project targeting accessibility problems in public transport for people with cognitive functional limitations (CFLs). The objective was to describe and compare different assessment perspectives of long-term CFLs among community citizens having had CFLs in the acute stroke phase but with moderate physical limitations. Eighty-four participa
Triple-negative breast cancer (TNB) has poor prognosis and moreover patients with TNB do not benefit from established targeted drugs with endocrine therapy or trastuzumab. The aim of the study was to analyze the prevalence of candidate biomarkers in tumors from patients with TNB. Tissue microarrays were prepared from primary tumors from premenopausal breast cancer patients (500/564) randomized to
Background/Aims: Whether age at onset influences functional deterioration in Alzheimer disease (AD) is unclear. We, therefore, investigated risk factors for progression in activities of daily living (ADL) and nursing home placement (NHP) in cholinesterase inhibitor (ChEI)-treated patients with early-onset AD (EOAD) versus late-onset AD (LOAD). Methods: This 3-year, prospective, observational, mult
Objectives: Patients with antineutrophil cytoplasmatic antibodies-associated vasculitides (AAV) exhibit higher mortality than the general population. In the current study, we assessed whether cluster affiliation based on clinical presentation might predict mortality. Methods: With case record review, the outcomes for a population-based cohort of patients diagnosed with AAV in southern Sweden (catc
Objective: The study aimed to examine the vocal behavior and self-assessed vocal health in women with varying everyday vocal load and functional voice problems, including patients with functional dysphonia, in three conditions: work, leisure, and a vocal loading task (VLT). Study Design: This is a longitudinal controlled, clinical trial. Methods: Fifty (n = 50) female subjects were tracked during
Abstract Recent years have seen a number of competing theories of concepts within philosophy of mind, supplanting the classical definitionist and imagist accounts: among them, Jerry Fodor's informational atomism, Jesse Prinz's proxytypes theory, and -- of course -- Peter Gärdenfors' (2004) conceptual spaces theory (CST). On the whole there has been little empirical investigation into the competing
Neural interface electrodes that can record from neurons in the brain for long periods of time will be of great importance to unravel how the brain accomplishes its functions. However, current electrodes usually cause significant glia reactions and loss of neurons within the adjacent brain parenchyma. To address this challenge, a novel, polymer-based neural probe, with protrusions tailored to the
We compare different preference restrictions that ensure the existence of a stable roommate matching. Some of these restrictions are generalized to allow for indifferences as well as incomplete preference lists, in the sense that an agent may prefer remaining single to matching with some agents. We also introduce a new type of cycles and in greater detail investigate the domain of preferences that
Many everyday activities, such as engaging in conversation or listening to a story, require us to sustain attention over a prolonged period of time while integrating and synthesizing complex episodic content into a coherent mental model. Humans are remarkably capable of navigating and keeping track of all the parallel social activities of everyday life even when confronted with interruptions or ch
Introduction: Patients with acromegaly can be treated with surgery, medical therapy and/or radiation therapy. For the patients not being cured with surgery, treatment with somatostatin analogues (SSAs) is the primary therapy. SSA can be taken by self- or partner-administered injections in addition to being given by a nurse at a clinic. The aim was to assess if patients with acromegaly prefer self-
