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The hallmark of severe haemophilia, defined as a circulating level of factor (F) VIII (haemophilia A cases) or FIX (haemophilia B cases) of < 1%, is recurrent bleeding into muscles and joints (haemarthroses) from an early age of life. The inevitable result of such bleeding is progressive joint damage, leading to disabling arthritis that is typically evident within the first 2 decades of life in pe
OBJECTIVES: Despite the recent introduction of new peroral drugs as well as neurosurgical methods for Parkinson's disease, treatment of late stage parkinsonian patients remains difficult and many patients become severely handicapped because of fluctuations in their motor status. Injections and infusions of apomorphine has been suggested as an alternative in the treatment of these patients, but the
Agricultural fertilization significantly affects arbuscular mycorrhizal fungal (AMF) community composition. However, the functional implications of community shifts are unknown, limiting understanding of the role of AMF in agriculture. We assessed AMF community composition at four sites managed under the same nitrogen (N) and phosphorus (P) fertilizer regimes for 55 yr. We also established a glass
Quantum communication has been widely used as an important component in many applications of quantum information science. It is naturally utilised in the fields of quantum optics and photonics. Quantum communication and quantum cryptography have been studied as a popular subject in research for many years. However, most of the quantum-communication devices are oversized and non-portable. This prob
The measures to mitigate and adapt to global warming constitute fundamental changes to human- environmental interactions and peoples' deep-rooted habits and lifestyles. However, tools to deal with climate change have varying impacts on groups constituting society, leading to different climate change- related attitudes and behaviors. This thesis examines differences depending on individuals'
This study investigates the causal effect of environmental attitudes on number of children one has. The aim is to contribute to the recent discussion on reducing carbon emissions by having fewer children. Using data from the World Values Survey Association, an instrumental variables approach was used to analyse the research question. Moreover, a factor analysis was conducted in order to create a v
This study revives a heavily debated relationship between government debt accumulation and economic growth. Although indebtedness levels stay high, current economic growth forecasts seem optimistic not only in the euro area but in other advanced countries, as well. 24 advanced OECD economies are investigated to understand if financial outcomes are detrimental to the real economic variables in the
Cerebral edema is a common complication following moderate and severe traumatic brain injury (TBI), and a significant risk factor for development of neuronal death and deterioration of neurological outcome. To this date, medical approaches that effectively alleviate cerebral edema and neuronal death after TBI are not available. Glucagon-like peptide-1 (GLP-1) has anti-inflammatory properties on ce
Background - This interim 12-month analysis is a part of an open-label, observational, prospective study on health outcomes and cost impact of levodopa/carbidopa intestinal gel (LCIG, Duodopa) in Parkinson disease (PD). The specific aim was to investigate clinical and health-related quality of life (HRQoL) effects in routine care. Methods - Unified PD rating scale (UPDRS) was the primary efficacy
Background: Findings from early observational studies have suggested that the intake of dietary fat might be a contributing factor in the etiology of prostate cancer. However, the results from more recent prospective studies do not support this hypothesis, and the possible association between different food sources of fat and prostate cancer risk also remains unclear. Objective: The objectives wer
Several studies have found that the homocysteine plasma level is associated with cardiovascular disease. The authors previously described a relationship between concentrations of fibrinogen and other inflammation-sensitive plasma proteins, namely, alpha1-antitrypsin, ceruloplasmin, haptoglobin, and orosomucoid (alpha1-acid glucoprotein) and the incidence of myocardial infarction (MI). Whether leve
This study revives a heavily debated relationship between government debt accumulation and economic growth. Although indebtedness levels stay high, current economic growth forecasts seem optimistic not only in the euro area but in other advanced countries, as well. 24 advanced OECD economies are investigated to understand if financial outcomes are detrimental to the real economic variables in the
Groundwater quality and quantity are two major challenges in arid and semi-arid regions, due to their critical roles in sustainable agricultural development. Irrigated lands are spread all over Urmia Lake's surrounding plains in Iran. Due to the risk of saltwater intrusion as a result of over-exploitation from groundwater resources, it is important to monitor the groundwater quality and quantity t
The ability of insects to cope with stressful temperatures through adaptive plasticity has allowed them to thrive under a wide range of thermal conditions. Developmental plasticity is generally considered to be a non-reversible phenotypic change, e.g. in morphological traits, while adult acclimation responses are often considered to be reversible physiological responses. However, physiologically m
Radio based positioning or tracking solutions typically require wideband signals or phase coherent antennas. In this paper, we present a target tracking method based on received non-coherent signal strength differences (RSSDs) between antennas for outdoor Internet-of-things (IoT) scenarios. We introduce an RSSD model based on classical path-loss models. With known antenna patterns and antenna arra
Ohövliga beteenden har visats vara ett vanligt förekommande fenomen, med negativa effekter för individer, organisationer och samhället. Under de senaste två decennierna har omfattande forskningsfokus lagts på att öka kunskapen kring ohövlighet i arbetslivet, bland annat genom att undersöka utsatta, och utövare av ohövlighet. Trots detta så har färre studier undersökt hur ohövliga beteenden påverkaWorkplace incivility has been found to be a ubiquitous phenomenon, with adverse effects for individuals, organizations and society. Over the past two decades, substantial research efforts have been made to increase knowledge about workplace incivility, including investigations of its targets and perpetrators. However, less research has been conducted on how workplace incivility impacts bystanders.
Aims: The aim of this study was to investigate the pattern, causes, and predictors of all new hospitalizations in patients who underwent transcatheter aortic valve implantation (TAVI). Methods and results: The nationwide Swedish TAVI registry was merged with other mandatory healthcare registries, which enabled the analysis of all TAVI procedures, new hospital admissions, and death between the year
Background: In contact dermatitis, it is crucial to understand and remember the outcome of patch testing. Unfortunately, many patients do not remember the results of their patch tests. Objectives: Our aim was to evaluate the effects of an intervention programme in which extensive information on specific contact allergy was provided, in individuals with positive patch test reactions. Methods: The s
The Global Prevalence of Infections in Urology (GPIU) study is a worldwide-performed point prevalence study intended to create surveillance data on antibiotic resistance, type of urogenital infections, risk factors and data on antibiotic consumption, specifically in patients at urological departments with healthcare-associated urogenital infections (HAUTI). Investigators registered data through a
