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In cases of suspected scaphoid fracture where the initial radiographs are negative, a supplementary MRI, or alternatively CT, should be carried out within three to five days. Fracture classification, assessment of dislocation as well as evaluation of fracture healing is best done on CT with reconstructions in the coronal and sagittal planes, following the longitudinal axis of the scaphoid. After a
Herein we report an efficient hydrosilylation strategy to selectively defunctionalize biomass-derived levulinic acid into value-added chemicals such as pentane-1,4-diol, pentan-2-ol, 2-MTHF and C5 hydrocarbons by using cost-effective silanes and the commercially available catalyst B(C6F5)3 at room temperature. All reactions work well in chlorinated solvents but, as a greener alternative, most reac
Archiving the Spaces of Anxiety exhibition in Beijing, China curated by Shuyu ChenArchiving the Spaces of Anxiety takes its form from a transitional path that links Kafka’s unfinished short story The Burrow (1923–1924) and Wu Li’s painting White Cloud and Green Mountain (1668), by looking into a set of intertwining relations between the external space that surrounds us, and the internal space that
Importance: Endovascular treatment is not recommended for aortic pathologies in patients with connective tissue diseases (CTDs) other than in redo operations and as bridging procedures in emergencies. However, recent developments in endovascular technology may challenge this dogma. Objective: To assess the midterm outcomes of endovascular aortic repair in patients with CTD. Design, Setting, and Pa
Context The context of this research is software process improvement (SPI) success factors for small and medium Web companies. Objective The primary objective of this paper is to propose a theoretical framework of SPI success factors for small and medium Web companies. Method The theoretical framework presented in this study aggregated the results of three previous research phases by applying prin
BACKGROUND: Analyses of clinical outcomes following radiotherapy (RT) have advanced our understanding of fundamental radiobiological characteristics in head and neck squamous cell carcinoma (HNSCC). Low fractionation sensitivity appears to be a common feature, as well as susceptibility to changes in overall treatment time (OTT). Large tumors should be harder to cure if a successful RT requires the
Background: Severe left-sided cardiac obstructions are associated with high morbidity and mortality if not detected in time. The correct prenatal diagnosis of coarctation of the aorta (CoA) is difficult. Fetal cardiac magnetic resonance imaging (CMR) may improve the prenatal diagnosis of complex congenital heart defects. Flow measurements in the ascending aorta could aid in predicting postnatal Co
Objective To date, the major pathways contributing to cardiovascular disease among night shift workers remain poorly understood. MicroRNAs (miRNAs) have been identified as novel regulators of cardiovascular risk factors and are estimated to control more than 30 candidate miRNAs among night shift workers.Materials and Methods RNA was extracted from plasma samples of 110 night and 90day shift worker
Background: Vasovagal syncope (VVS) is a common yet challenging condition with limited effective treatments. Elastic compression stockings (ECS) have been proposed as a potential therapy, but their real-world effectiveness remains unclear. Objectives: This study sought to compare the effectiveness of lower extremity compression with thigh-high ECS vs sham stockings for the prevention of VVS recurr
Protein crystallization is key to determining the structure of proteins at atomic resolution. It can occur naturally, including in pathological pathways, for instance with aquaporin and γ-crystallin proteins. A fundamental understanding of the underlying crystallization process is both technologically and biologically relevant. A multitechnique approach is employed here to investigate protein crys
Our viewpoint highlights the challenges faced by women in the Induced Polarization (IP) community (and elsewhere), particularly the persistent gender imbalance in scientific workshops. This underrepresentation in leadership roles, presentations and discussions reflects broader systemic biases in academia. By sharing the experience of the 7th IP workshop, where the organizing team made deliberate eff
A core principle of the Safe System approach is shared responsibility among stakeholders and road users. Traditionally, public actors have shouldered most of the stakeholder responsibility, and traffic safety has mainly been viewed as a duty of governments [1,2]. However, the United Nations and the World Health Organisation call on all stakeholders, both public and private, to take on the responsi
Introduction Neoadjuvant therapy is the standard of care for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC). Studies on first-generation antibody-drug conjugates, such as trastuzumab emtansine (T-DM1), showed equal or slightly lower efficacy than chemotherapy combined with dual HER2 blockade. Trastuzumab deruxtecan (T-DXd) is a next-generation conjugat
BACKGROUND: The ORBITA and ORBITA-2 trials have provided valuable insights into the effects of coronary revascularization in chronic coronary syndrome (CCS). However, uncertainties remain regarding the efficacy of revascularization on symptoms in large real-world populations. To evaluate the efficacy of revascularization, we used dispensed long-acting nitrates as a proxy for the presence of angina
This study aimed to test and validate a dual-time-window (DTW) protocol for 6-(fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]MK6240) dynamic PET imaging in experimental datasets acquired in human subjects. Methods: DTW protocols were tested and validated in datasets previously collected in 25 participants: 13 were cognitively normal, 10 had mild cognitive impairment, and 2
When searching for an object in my pocket, I can clearly perceive the edges, shape, and hardness of the items I touch — regardless of which part of my fingers makes contact and despite large sensorimotor noise. What accounts for these perceptual invariants? Vincent Hayward introduced key elements to investigate this question, by (i) analyzing mechanical spatiotemporal invariants emerging from the
Correlated electron physics is intrinsically a multiscale problem, since high-energy electronic states screen the interactions between the correlated electrons close to the Fermi level, thereby reducing the magnitude of the interaction strength and dramatically shortening its range. Thus the handling of screening is an essential ingredient in the first-principles modeling of correlated electron sy
Any new technology and any form of contact between cultures will necessarily lead to change. ICTs are in this sense far from unique. However, ICTs have rapidly come to occupy a prominent position our societies, and are shaping the lives of young people in ways that we could not have imagined only a decade ago. These technologies allow almost immediate access to a wealth of knowledge and knowhow, a
Background: Infants with congenital heart defects (CHD) are at risk for white matter brain injury. This novel rat pup model characterizes the systemic effects of intravasal cell-free hemoglobin and hyperoxia, hypothesizing that immature endogenous scavenging systems relate to increased vulnerability to conditions present during cardiopulmonary bypass (CPB).Methods: Plasma pharmacokinetics of cell-
