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The compressibility of a protein relates to its stability, flexibility, and hydrophobic interactions, but the measurement, interpretation, and computation of this important thermodynamic parameter present technical and conceptual challenges. Here, we present a theoretical analysis of protein compressibility and apply it to molecular dynamics simulations of four globular proteins. Using additively
INTRODUCTION: Despite favourable results from structured face-to-face treatment of osteoarthritis (OA) in Sweden through the Better management of patients with OsteoArthritis (BOA) initiative, only around 20% of people with knee or hip OA receive the primary treatment recommended by international guidelines (ie, information, exercise, weight management). In 2014, a digital treatment programme name
Phase shifter-based hybrid beamforming has received a lot of attention at millimeter-wave frequencies for cellular communications. Nevertheless, the implementation complexity of such beamformers is rather high due to the complexities involved in designing and fabricating the required radio-frequency (RF) circuits. In contrast, lens-based RF beamformers significantly reduce the implementation compl
A new simplifed formula is derived for the absorption cross section of small dielectric ellipsoidal particles embedded in lossy media. The new expression leads directly to a closed form solution for the optimal conjugate match with respect to the surrounding medium, i.e. the optimal permittivity of the ellipsoidal particle that maximizes the absorption at any given frequency. This defnes the optim
Background: Low-dose opioids can relieve breathlessness but may be underused in late-stage COPD due to fear of complications, contributing to poor symptom control. Objectives: We aimed to study the period prevalence and indications of opioids actually prescribed in people with end-stage COPD. Methods: The study was a longitudinal, population-based study of patients starting long-term oxygen therap
Objectives: Clinical trials have demonstrated the efficacy of vedolizumab in inflammatory bowel disease (IBD). However, these findings may not reflect the clinical practice. Therefore, we aimed to describe a vedolizumab-treated patient population and assess long-term effectiveness. Materials and methods: Patients initiating vedolizumab between 1 June 2014 and 30 May 2015 were identified through th
The purpose of this study is to address the main reasons that limit Jordanian women from undertaking expatriation, based on the assumption that Arab women’s opportunities for international engagement may be compromised by local cultural and institutional issues. Design/methodology/approach: A cross-sectoral survey with 60 Jordanian expatriates (30 women and 20 men) located in EU countries and the
RelA/SpoT Homologue (RSH) proteins, named for their sequence similarity to the RelA and SpoT enzymes of Escherichia coli, comprise a superfamily of enzymes that synthesize and/or hydrolyze the alarmone ppGpp, activator of the "stringent" response and regulator of cellular metabolism. The classical "long" RSHs Rel, RelA and SpoT with the ppGpp hydrolase, synthetase, TGS and ACT domain architecture
Objectives: Thermal and mechanical stresses during osteotomy preparation can impair implant osseointegration. This study investigated implant osseointegration following the measurement of temperature exposure during osteotomy drilling, varying drill design, sequence, and drill wear. Materials and methods: 36 tapered implants were placed in a mandibular minipig model after guided drilling of implan
BACKGROUND/AIMS: The aim of this study was to develop a risk model for intraoperative complication (IC) during cataract surgery, defined as posterior capsule rupture and/or zonular dehiscence, and to include previous intravitreal therapy (pIVT) in the model.METHODS: This retrospective register-based study covered patients reported to the Swedish National Cataract Register (SNCR) between 1 January
Abstract in UndeterminedContextThe key for effective problem prevention is detecting the causes of a problem that has occurred. Root cause analysis (RCA) is a structured investigation of the problem to identify which underlying causes need to be fixed. The RCA method consists of three steps: target problem detection, root cause detection, and corrective action innovation. Its results can help with
Aim: To characterize early amplitude-integrated electroencephalogram (aEEG) and single-channel EEG (aEEG/EEG) in very preterm (VPT) infants for prediction of long-term outcome. Patients: Forty-nine infants with median (range) gestational age of 25 (22-30) weeks. Methods: Amplitude-integrated electroencephalogram/EEG recorded during the first 72 h and analysed over 0-12, 12-24, 24-48 and 48-72 h,
Purpose: To demonstrate a novel method for tracking of head movements during MRI using electroencephalography (EEG) hardware for recording signals induced by native imaging gradients. Theory and Methods: Gradient switching during simultaneous EEG–fMRI induces distortions in EEG signals, which depend on subject head position and orientation. When EEG electrodes are interconnected with high-impedanc
Purpose: Image-based analysis of breast tumor growth rate may optimize breast cancer screening and diagnosis by suggesting optimal screening intervals and guide the clinical discussion regarding personalized screening based on tumor aggressiveness. Simulation-based virtual clinical trials (VCTs) can be used to evaluate and optimize medical imaging systems and design clinical trials. This study aim
Background Despite well-established guidelines for managing major depressive disorder, its extensive disability burden persists. This Value of Treatment mission from the European Brain Council aimed to elucidate the nature and extent of gaps between best-practice and current-practice care, specifically to: 1. Identify current treatment gaps along the care pathway and determine the extent of these
Context. Measuring the abundances of neutron-capture elements in Galactic disk stars is an important part of understanding key stellar and galactic processes. In the optical wavelength regime a number of different neutron-capture elements have been measured; however, only the s-process-dominated element cerium has been accurately measured for a large sample of disk stars from the infrared H band.
Background: Process evaluations are an important component in the interpretation and understanding of outcomes in trials. The Online Remote Behavioural Intervention for Tics (ORBIT) study is a randomized controlled trial evaluating the effectiveness of an Internet-delivered behavioural intervention (called BIP TIC) compared to an Internet-delivered education programme aimed at children and young p
Most often, the laminar burning velocity (SL) of ammonia was measured in mixtures diluted by nitrogen bearing in mind its potential use as an alternative carbon-free fuel. Replacing the diluent with argon can increase the flame temperature and thus provide additional targets for validating pertinent detailed kinetic models. The SL data for ammonia + oxygen + argon mixtures are scarce; therefore, i
Beaches are important coastal features that provide vital ecosystem services; however, these systems are threatened by coastal erosion, sea-level rise, and coastal squeeze. Beach nourishments are a commonly applied coastal protection measure to mitigate erosion and flood risks while maintaining or enhancing recreational values. Nourishments vary in scale from mega-nourishments to small-scale nouri
