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This article presents the analysis of a large survey on file-sharing that was conducted in April 2011 with over 75,000 respondents from all over the world. The study, also known as The Research Bay, due to that it was conducted in collaboration with the infamous BitTorrent site The Pirate Bay, by the Cybernorms research group. The aim of the online study of The Pirate Bay community has been to des
Today independent publishers are offering digital libraries with fulltext archives. In an attempt to provide a single user-interface to a large set of archives, the studied Article-Database-Service offers a consolidated interface to a geographically distributed set of archives. While this approach offers a tremendous functional advantage to a user, the fulltext download delays caused by the networ
The hydrophobic contributions of 17 individual peptides, fused to the N-terminal of Bacillus stearothermophilus lactate dehydrogenase (LDH) were studied by hydrophobic interaction chromatography (HIC) and aqueous two-phase system (ATPS). The constructs were sequenced from a protein library designed with a five-amino acid randomised region in the N-terminal of an LDH protein. The 17 LDH variants an
Parasol is a computer program for calculating the solar and thermal properties of windows with sunshades and the energy demands of a room with a window/shading system. The program has three main features. One of them is a calculation of g, T and U for normal incidence of beam irradiation, which is performed as soon as a window or an internal/interpane sunshade is selected. The other two are based
Thymidine kinase 1 (TK1) provides a crucial precursor, thymidine monophosphate (dTMP), for nucleic acid synthesis, and the activity of TK1 increases up to 200-fold during the S-phase of cell division in humans. An important part of the regulatory check-points is the ATP and enzyme concentration-dependent transition of TK1 from a dimer with low catalytic efficiency to a tetramer with high catalytic
Since its introduction more than 40 years ago, electronic fetal monitoring has become widely used for intrapartum surveillance to determine fetal wellbeing in labor. Although fetal hypoxia and acidosis are reflected in changes in fetal heart rate, there is no evidence that cardiotocography has been effective in reducing neonatal morbidity related to fetal distress occurring during labor. Indeed th
The twisted elliptical tube heat exchangers with the novel coupling-vortex chessboard tube layout (TETHXs-CV) were simulated with the RNG k-ε model in software Fluent 15.0. The shell-side flow pattern at the tangential points between adjacent tubes in traditional TETHX is countercurrent while that in TETHX-CV is concurrent, which helps enhance heat transfer capability without any extra manufacturi
Background: In many parts of the world, roadsides are regularly managed for traffic-safety reasons. Hence, there are similarities between roadsides and certain other managed habitats, such as wooded pastures and mown or grazed grasslands. These habitats have declined rapidly in Europe during the last century. For many species historically associated with them, roadsides may function as new primary
Previous work has shown that amylose (AM) can cross-link hydrophobically modified polymers by inclusion complexation, whereby thermoreversible cold-setting gels are formed. Here we investigate the complexation of AM with different samples of hydrophobically modified ethyl(hydroxyethyl) cellulose (HMEHEC), distinguished by differences in the architecture of the hydrophobes (the hydrophobic side cha
Evidence supports an important role for beta-amyloid (A beta) in the pathogenesis of Alzheimer's disease ( AD). Here, we investigate baseline levels of the 40- and 42-amino-acid-long A beta peptides (A beta 40 and A beta 42) in cerebrospinal fluid (CSF) from a cohort of patients with mild cognitive impairment (MCI, n = 137) in relation to the final diagnosis after 4 - 6 years of follow-up time. CS
A brief period of rapidly recurring hippocampal seizures can lead to the progressive development of a permanent increase of seizure susceptibility over several weeks, so-called 'delayed kindling'. We have analyzed seizure parameters critical for the induction of delayed kindling in two strains of rats characterized by fast and slow rates of traditional kindling, respectively. Forty seizures were p
The cancer microenvironment has been attracting increasing attention as the realization of its importance for both disease treatment and malignant progression. Here the aim was to elucidate some of the effects and mechanisms of the tumor microenvironment related to the extracellular matrix (ECM). We hypothesized that collagen fibril assembly is an instrumental component in the formation of the bar
Testicular germ cell cancer is preceded by a pre-invasive stage called carcinoma-in-situ (CIS). The majority, if not all cases of CIS will progress into invasive cancer. Today, the only reliable way of diagnosing CIS is by performing open testicular biopsy. There is an ongoing search for non-invasive techniques for diagnosing early testicular neoplasia. The possibility of using ultrasound of the t
In contrast with human hemoglobin (Hb) in red blood cells, plant Hbs do not transport oxygen, instead research points towards nitrogen metabolism. Using comprehensive and integrated biophysical methods we characterized three sugar beet Hbs: BvHb1.1, BvHb1.2 and BvHb2. Their affinities for oxygen, CO, and hexacoordination were determined. Their role in nitrogen metabolism was studied by assessing t
Micelles play an important role in both experimental and computational studies of the effect of lipid interactions on biological systems. The spherical geometry and the dynamical behavior of micelles makes generating micelle structures for use in molecular simulations challenging. An easy tool for generating simulation-ready micelle models, covering a broad range of lipids, is highly desirable. He
In this paper we consider calibration of hydraulic models for district heating networks based on operational data. We extend previous theoretical work on the topic to handle real-world complications, namely unknown valve characteristics and hysteresis. We generate two datasets in the Smart Water Infrastructure Laboratory in Aalborg, Denmark, on which we evaluate the proposed procedure. In the firs
Time-domain spectroscopy encompasses a wide range of techniques, such as Fourier-transform infrared, pump-probe, Fourier-transform Raman, and two-dimensional electronic spectroscopies. These methods enable various applications, such as molecule characterization, excited state dynamics studies, or spectral classification. Typically, these techniques rarely use sampling schemes that exploit the prio
We demonstrate reliable machine-learned tuning of quantum-dot-based artificial Kitaev chains to Majorana sweet spots, using the covariance matrix adaptation algorithm. We show that a loss function based on local tunneling spectroscopy features of a chain with two additional sensor dots added at its ends provides a reliable metric to navigate parameter space and find points where crossed Andreev re
In this paper, I argue for how environmental psychology as a discipline could benefit both conceptually and practically from considering basic psychological needs as specified within Self-Determination Theory (Ryan & Deci, 2017). I begin with a definition of basic psychological needs as “innate psychological nutriments that are essential for ongoing psychological growth, integrity, and well-be
Pilots in long-duration flight missions in single-seat aircraft may be affected by fatigue. This study determined associations between cognitive performance, emotions and physiological activation and deactivation–measured by heart rate variability (HRV)–in a simulated 11-h flight mission in the 39 Gripen aircraft. Twelve participants volunteered for the study. Perceived fatigue was measured by the
