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Background: To quantify cardiovascular health (CVH), the American Heart Association (AHA) recently launched an updated construct of the “Life's Simple 7” (LS7) score, the “Life's Essential 8” (LE8) score. This study aims to analyse the association between both CVH scores and carotid artery plaques and to compare the predictive capacity of such scores for carotid plaques. Methods: Randomly recruite
New imaging technologies utilising X-rays and radiopharmaceuticals have developed rapidly. Clinical application of computed tomography (CT) has revolutionised medical imaging and plays an enormous role in medical care. Due to technical improvements, spatial, contrast and temporal resolutions have continuously improved. In spite of significant reduction of CT doses during recent years, CT is still
Objective: To study the impact of GH dose and age at GH start in girls with Turner syndrome (TS), aiming for normal height and age at pubertal onset (PO) and at adult height (AH). However, age at diagnosis will limit treatment possibilities. Methods: National multicenter investigator-initiated studies (TNR 87-052-01 and TNR 88-072) in girls with TS, age 3–16 years at GH start during year 1987–1998
Purpose: Proteases have been implicated in cancer progression and invasiveness. We have investigated the activities, as opposed to simple protein levels, of selected aminopeptidases in urine specimens to serve as potential novel biomarkers for urothelial cancer. Experimental design: The unique urinary proteomes of males and females were profiled to establish the presence of a gender-independent se
The immune control of tuberculosis (TB) infection could be influenced by pregnancy. To elucidate this, we longitudinally characterized Mycobacterium tuberculosis (Mtb)-specific and nonspecific immune responses in women during pregnancy and postpartum. HIV-uninfected women without past or current active TB, and with blood samples available from the 1st/2nd trimester, 3rd trimester, and 9 months pos
I Sverige spelar förhandlingar mellan arbetsgivare och fackliga organisationer en avgörande roll för löner och andra anställningsvillkor. Anders Kjellberg visar i sitt kapitel att den svenska arbetsmarknadsmodellen kännetecknas av partsreglering (kollektivavtal) snarare än statsreglering (lagstiftning). Trepartsöverenskommelser förekommer också. Huvudavtalet 2022 mellan arbetsmarknadens parter ing
BACKGROUND AND PURPOSE: Treatment of cancer with immune checkpoint inhibitors (ICIs) entails a risk of immune-related adverse events (irAEs). Data on the treatment of immune-related enterocolitis (irEC) in patients with inadequate symptom control after treatment with standard therapy including corticosteroids, infliximab, and vedolizumab are scarce. Based on limited data, recommendations include t
Increasing the amount of renewable generation in distribution networks is a fundamental part of the energy transition. Multiple methods exist to increase the hosting capacity in a grid, to allow larger injections of generation and more efficiently utilize existing infrastructure before operational limits are breached. In this thesis, the method studied for this is network reconfiguration. Many dis
Background: In Alzheimer’s disease (AD), the associations between tau pathology and brain atrophy and cognitive decline are well established, but imperfect. We investigate whether cerebrospinal fluid (CSF) biomarkers of biological processes (vascular, synaptic, and axonal integrity, neuroinflammation, neurotrophic factors) explain the disconnection between tau pathology and brain atrophy (brain re
Phylogenetic inference is challenged by genealogical heterogeneity amongst molecular markers. Such discordance is driven predominantly by incomplete lineage sorting (ILS) and interspecific gene flow, and bears attendant consequences for the accurate resolution of species relationships. Understanding the distribution of gene conflict in organismal genomes is, therefore, a key aspect of phylogenetic
Nonclusion is aligned with Universal Design and involves a critical approach to the categorisation of people. Specifically, nonclusion resists categorisations of bodies/roles and does not come with predefined or presupposed limits in terms of who something is meant for. While UD and nonclusion generally target Design and Architecture, this article explores how nonclusion can be conveyed through te
The importance of using efficient bases for current expansion in numerical computations of electromagnetic field problems has been emphasized for several decades. It is well known that the basis functions should approximate the physical current (electric or magnetic) to some extent. Moreover, for efficiency, it is reasonably to require that only a few basis functions are needed in order to obtain
We present the fabrication and characterization of single mode waveguides fabricated monolithically in SU-8. SU-8 is a negative resist, which can be structured by UV lithography followed by a baking step to induce cross-linking. As a material platform, SU-8 is well suited for systems used for biochemical analysis, as it possesses very high chemical resistance and good mechanical stability. Here we
Scalable and reliable distributed object-oriented computing (DOC) middleware systems is an important technology in, for example, telecommunications service logic and distributed web servers. The Common Object Request Broker Architecture (CORBA), developed by the Object Management Group (OMG) is a speci cation of a common platform for DOC systems. CORBA acts as middleware, by inserting itself betwe
Importance: Clonal hematopoiesis of indeterminate potential (CHIP) may contribute to the risk of atrial fibrillation (AF) through its association with inflammation and cardiac remodeling. Objective: To determine whether CHIP was associated with AF, inflammatory and cardiac biomarkers, and cardiac structural changes. Design, Setting, and Participants: This was a population-based, prospective cohort
PurposeCare has been theorized as a relational practice, but the research has focused on providers rather than users. Older care users have been cast in a passive role, and their relational activities to help with the provision of their care or to support those who provide it are underexplored. The purpose of this study is to develop knowledge about home care use as a form of relational ‘work’.Met
Mutations in GBA1 cause Gaucher disease and are the most important genetic risk factor for Parkinson’s disease. However, analysis of transcription at this locus is complicated by its highly homologous pseudogene, GBAP1. We show that >50% of short RNA-sequencing reads mapping to GBA1 also map to GBAP1. Thus, we used long-read RNA sequencing in the human brain, which allowed us to accurately quantif
