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Introduction: Debilitating clinical complications in von Willebrand disease (VWD) can affect health-related quality of life (HRQoL), increase healthcare costs and cause long-lasting consequences. However, the magnitude of these burdens needs to be more fully explored. Aim: To estimate the prevalence and burden of clinical complications, the impact on HRQoL and the economic burden associated with V
This study introduces an efficient workflow for functional data analysis in classification problems, utilizing advanced orthogonal spline bases. The methodology is based on the flexible Splinets package, featuring a novel spline representation designed for enhanced data efficiency. The focus here is to show that the novel features make the package a powerful and efficient tool for advanced functio
Extreme Value Theory (EVT) is the state-of-the-art method for proactive prediction of accident frequency from traffic interactions on a microscopic scale. The main advantage of using EVT is to predict unobserved critical events based on one or more Surrogate Measures of Safety (SMoS) (single- or multivariate EVT) through a mathematical extrapolation of extreme interactions. Such interactions are q
Easy, low‐threshold access is widely regarded as a major advantage of online services. In Sweden, several municipalities are striving to increase the accessibility of their social services by responding to anonymous users online. This article considers the nature of the accessibility of these online services. Two online platforms were studied: (quasi‐)synchronous online chats and asynchronous onli
Purpose: To analyse risk of osteoporotic fractures in foreign-born individuals migrating to Sweden at different ages, compared to Swedish-born individuals. Methods: This was a nationwide open cohort study including individuals ≥30 years of age at baseline (N = 4,715,081). Foreign-born individuals were divided as having arrived to and being registered in Sweden from the ages 0–30 years of age or >3
Zircons from anatectic melts of the country rocks of three Proterozoic mafic-ultramafic intrusions from the Sveconorwegian Province in SW Sweden were microanalyzed for U-Th-Pb and rare earth elements. Melting and interaction of the wall rocks with the intrusions gave rise to new magmas that crystallized zircon as new grains and overgrowths on xenocrysts. The ages of the intrusions can be determine
Entanglement has the ability to enhance the transmission of classical information over a quantum channel. However, fully harvesting this advantage typically requires complex entangling measurements, which are challenging to implement and scale with the system's size. In this Letter, we consider a natural quantum information primitive known as a random access code in which the message to be communi
Modern imaging atmospheric Cherenkov telescopes have extensively observed young nearby supernova remnants (SNRs), with ages of about 1000 years or less, in the very-high-energy (VHE) gamma-ray band. These efforts resulted in the detection of VHE emission from three young SNRs – Cassiopeia A, Tycho, and SN 1006 – and provided significant evidence for emission from the more distant Kepler’s SNR. How
Easy and low-threshold access is considered to be a major advantage of online services. In Sweden, social services in several municipalities strive to increase their accessibility by responding to anonymous users online. This paper raises the question about the nature of accessibility that the online social services entail. Two online platforms were studied: synchronous online chats and asynchrono
Allergic contact dermatitis (ACD) caused by textile dyes is not uncommon. The main dye allergens belong to disperse dyes which are used for coloring synthetic textile fibers. The European baseline series is not suitable for the reliable detection of textile dye allergy although p-phenylenediamine has been considered as a marker for contact allergy to disperse azo dyes. In order to diagnose ACD fro
In patch testing, a standardized manner of testing and of patch test reading is essential. In this chapter, the basic aspects of these issues are discussed, as well as thoughts on when patch testing should be probably, with what to patch test, especially considering the baseline series, and pitfalls when patch test reading.
Prostate cancer is a highly heterogeneous disease, understanding the crosstalk between complex genomic and epigenomic alterations will aid in developing targeted therapeutics. We demonstrate that, even though snail family transcriptional repressor 2 (SNAI2) is frequently amplified in prostate cancer, it is epigenetically silenced in this disease, with dynamic changes in SNAI2 levels showing distin
Coking is a common catalyst deactivation route in industrial processes involving carbonaceous species. While coking is easy to diagnose, this is often performed by bulk analysis. Understanding specific symptoms such as pore blockage and obstruction of active sites is especially challenging for technical catalysts and requires a spatially-resolved approach. Here a combination of ptychographic X-ray
Recent developments in computer graphics and hardware technology enable easy access to virtual reality headsets along with integrated eye trackers, leading to mass usage of such devices. The immersive experience provided by virtual reality and the possibility to control environmental factors in virtual setups may soon help to create realistic digital alternatives to conventional classrooms. The im
This is the software artifact for the paper "Efficient Demand Evaluation of Fixed-Point Attributes Using Static Analysis" published in SLE 2024.This artifact supports the evaluation of a new demand-driven algorithm for efficient circular Reference Attribute Grammar evaluation, specifically designed to improve performance of higly circular applications, e.g., dataflow analyses for Java. The artifac
Phylogenetic inference is challenged by genealogical heterogeneity amongst molecular markers. Such discordance is driven predominantly by incomplete lineage sorting (ILS) and interspecific gene flow, and bears attendant consequences for the accurate resolution of species relationships. Understanding the distribution of gene conflict in organismal genomes is, therefore, a key aspect of phylogenetic
For magnetic field orientation of nonstructures to become a viable method to create high performance multifunctional nanocomposites, it is of paramount importance to develop a method that is easy to implement and that can induce long-range uniform nanostructural alignment. To overcome this challenge, inspired by low field nuclear magnetic resonance (NMR) technology, a highly uniform, high field st
