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Presynaptic calcium signalling in cerebellar mossy fibres

Whole-cell recordings were obtained from mossy fibre terminals in adult turtles in order to characterize the basic membrane properties. Calcium imaging of presynaptic calcium signals was carried out in order to analyse calcium dynamics and presynaptic GABA B inhibition. A tetrodotoxin (TTX)-sensitive fast Na+ spike faithfully followed repetitive depolarizing pulses with little change in spike dura

Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics

Introduction: Breast cancer is a profoundly heterogeneous disease with respect to biologic and clinical behavior. Gene-expression profiling has been used to dissect this complexity and to stratify tumors into intrinsic gene-expression subtypes, associated with distinct biology, patient outcome, and genomic alterations. Additionally, breast tumors occurring in individuals with germline BRCA1 or BRC

Visible effects of invisible Hidden Valley radiation

Assuming there is a new gauge group in a Hidden Valley, and a new type of radiation, can we observe it through its effect on the kinematic distributions of recoiling visible particles? Specifically, what are the collider signatures of radiation in a hidden sector? We address these questions using a generic SU(N)-like Hidden Valley model that we implement in PYTHIA. We find that in both the e(+)e(-

The effect of exercise on the absorption of inhaled human insulin in healthy volunteers

What is already known about this subject * Exercise is known to affect absorption of other inhaled substances, but so far there are no reports on the effect of exercise on the absorption of inhaled insulin in humans. What this paper adds * This report is the first to investigate the effect of exercise on the absorption of inhaled insulin. * In this study in healthy volunteers we found that exercis

A structure of persuasion in Galatians: Epistolary and rhetorical appeal in an aural setting

The purpose of this paper is to ponder the reception of the Letter to the Galatians in an aural setting. How did the first recipients react, what can we expect that they remembered after having listened to the letter? Are there structural elements in the letter that would have aided the aural reception of the letter? In four readings, the investigation traces textual indicators of interaction and

CreditGrades and the iTraxx CDS index market

In the study reported, the CreditGrades model was used to calculate credit default swap spreads and the spreads were compared with empirically observed CDS spreads for eight iTraxx indices covering Europe. Theoretical and empirical spread changes were found to be significantly correlated. Also, lagged theoretical spread changes were correlated with current iTraxx spread changes. The correlations i

Remote Gaming by Deliberate Cellphone Movement

The input device for Remote Gaming has matured from a simple pointing device to a wireless console and recently even motion sensors are added. Similar motion sensors have already been integrated in camera’s to provide for image stabilization. In the cellphone, global motion is foremost determined through image processing. The paper extends this concept to support gaming, while aiming for a low-com

Collaboration between relatives of frail elderly patients and nurses in acute hospital wards. Dimensions, prerequisites and outcome

Popular Abstract in Swedish Formålet var at undersøge samspillet mellem pårørende til svækkede ældre patienter og sygeplejepersonalet i akutte hospitalsafdelinger, samt at udvikle og teste et instrument til at undersøge, udfra pårørendes perspektiv, samspillets dimensioner i denne kontekst og associationen mellem samspil og tilfredshed med patientforløbet. Den underliggende antagelse for studiet vThe aim was to investigate collaboration between relatives of frail elderly patients and nurses in acute hospital wards, and to develop and test an instrument to investigate, from the relatives? perspective, dimensions of collaboration in this context and the association between collaboration and satisfaction with the hospital care trajectory. The underpinning assumption for the study was that rel

Modeling of the degradation of elastic properties due to the evolution of ductile damage

An elasto-plastic constitutive model for porous materials is formulated within the thermodynamic framework. The formulation facilitates a natural modeling of damage as well as growth and the shrinkage of voids. Metal plasticity is used for demonstrating the possibilities of the formulation. The yield function employed is assumed to depend upon the void-volume fraction, whereas the free energy is d

Steady periodic capillary-gravity waves with vorticity

In this paper we prove the existence of steady periodic two-dimensional capillary-gravity waves on flows with an arbitrary vorticity distribution. The original free-surface problem is first transformed to a second-order quasi-linear elliptic equation with a second-order quasi-linear boundary condition in a fixed domain by a change of variables. We then use local bifurcation theory combined with th

Frequency mixing and phase detection functionalities of three-terminal ballistic junctions

Three-terminal ballistic junctions (TBJs) are fabricated from a high-mobility InP/In0.75Ga0.25As heterostructure by electron-beam lithography. The voltage output from the central branch is measured as a function of the voltages applied to the left and right branches of the TBJs. The measurements show that the TBJs possess an intrinsic nonlinearity. Based on this nonlinearity, a novel room-temperat