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Dimension Reduction and Signal Decomposition for Genotype–Phenotype Relations

Over the last few decades, DNA sequencing has developed from costing billions of dollars to get the complete sequence of the human genome, to being a routine procedure performed in labs all around the world. This has transformed the field of experimental biology since measurements can be done at a level of detail that was not possible before. Still, the relationship between genotype and low-level

Electric bike navigation behaviour in pedestrian crowds

This study investigates the influence of pedestrian crowdedness on e-bike navigation behaviour in a controlled field experiment. The dataset includes a total of 1520 trajectories, including 18 pedestrians and one e-bike at a time. Based on the e-bike navigation through the pedestrians, the so-called “hindrance” concept was used to classify the data into two phases: passing (same-direction encounte

Regulation of survival and proliferation of human intestinal epithelial cells by leukotriene D4.

Popular Abstract in Swedish Inflammation is a protective response against injury or infection (the invading microbes or their toxins) with the aim being the removal of causal agent followed by the repair process. Without inflammation, infections would go unchecked and wounds would not heal. However, inflammation is like a double-edged sword. Though it is mainly a protective response, some times, iThe pro-inflammatory mediator, Leukotriene D4 (LTD4) is a product of arachidonic acid cascade and has been implicated in asthma and inflammatory bowel diseases. Prolonged inflammatory conditions like ulcerative colitis increases the risk for the development of cancer and the factors that induce the chronic immune response remain uncertain. In this context, in the present study, we examined if expo

Självmordsförsök bland narkotikamissbrukare

Popular Abstract in Swedish Denna avhandling handlar om en grupp narkotikamissbrukare som gjort självmordsförsök. Såväl självmord som självmordsförsök är betydligt vanligare bland narkotikamissbrukare jämfört med totalbefolkningen. Bland vårdade narkotikamissbrukare är det mellan 19 till 47 procent som gjort självmordsförsök. Det höga självmordsförsökstalet bland narkotikamissbrukare förklaras oftThe aim of this thesis is to describe suicide attempts in a group of drug abusers who previously had received treatment of their addiction. Another aim is to interpret and analyse the life situations that the individual associates with the suicide attempt. The dissertation is based on interviews conducted on two occasions with 92 drug abusers, 62 men and 30 women. The majority of the drug abusers

Swedish Butterfly Monitoring Scheme, annual report for 2012

This is the third annual report of the Swedish Butterfly Monitoring Scheme, a national monitoring programme coordinated by Lund University for the Swedish Environmental Protection Agency since 2010. The programme is a partnership between the Entomological Society of Sweden, the Swedish Environmental Protection Agency, Lund University, the Swedish University of Agricultural Sciences and the Swedish

Lean and six sigma – critical success factors revisited

Purpose – The purpose of this paper is to provide a review of the critical success factors (CSF) for lean and six sigma and an analysis of these CSF as compared to previously popular change methods. Design/methodology/approach – The paper uses a literature search and comparative analysis complemented with examples from previous case studies. Findings – With only slight variations, the critical suc

Quantitative Imaging-Biomarker in Prostate Cancer. Validation of Automated Bone Scan Index in the Context of Radiographic Disease Progression in Metastatic Castration Resistant Prostate Cancer

Background: Metastatic castration resistant prostate cancer (mCRPC) is a bone dominant lethal disease. Progression in bone scan of mCRPC disease is assessed with the Prostate Cancer Working Group (PCWG) two and three criteria, which relies on the appearance of two or more new lesions. There is an unmet need for a quantitative assessment that can build on the current progression criteria. This thes

An empirical assessment of the MODIS land cover dynamics and TIMESAT land surface phenology algorithms

Observations of vegetation phenology at regional-to-global scales provide important information regarding seasonal variation in the fluxes of energy, carbon, and water between the biosphere and the atmosphere. Numerous algorithms have been developed to estimate phenological transition dates using time series of remotely sensed spectral vegetation indices. A key challenge, however, is that differen

Screening over Speech in Unselected Populations for Clinical Trials in AD (PROSPECT-AD) : Study Design and Protocol

Background: Speech impairments are an early feature of Alzheimer’s disease (AD) and consequently, analysing speech performance is a promising new digital biomarker for AD screening. Future clinical AD trials on disease modifying drugs will require a shift to very early identification of individuals at risk of dementia. Hence, digital markers of language and speech may offer a method for screening

Experiences Creating a Framework for Smart Traffic Control using AWS IOT

Public clouds such as Amazon Web Services (AWS) and Microsoft’s Azure provide excellent capabilities for scalable Web applications and Hadoop-based processing. Recent ad- ditions to public clouds to support connected devices and IoT have the potential to similarly disrupt emerging home- grown and/or proprietary approaches. While early public cloud IoT success stories have focused on smaller-scale

Calibrating the Wildfire Decision Model using hybrid choice modelling

Wildfire occurrences is creating serious challenges for fire and emergency response services and a diverse range of communities around the world due to the increment of the occurrence of these disasters. As such, understanding the physical and social dynamics characterizing wildfires events is paramount to reduce the risk of these natural disasters. As such, one of the main challenges is to unders

Using ecological context to interpret spatiotemporal variation in natural selection

Spatiotemporal variation in natural selection is expected, but difficult to estimate. Pollinator-mediated selection on floral traits provides a good system for understanding and linking variation in selection to differences in ecological context. We studied pollinator-mediated selection in five populations of Dalechampia scandens (Euphorbiaceae) in Costa Rica and Mexico. Using a nonlinear path-ana

Assessing forest phenology : A multi-scale comparison of near-surface (UAV, spectral reflectance sensor, phenocam) and satellite (MODIS, sentinel-2) remote sensing

The monitoring of forest phenology based on observations from near-surface sensors such as Unmanned Aerial Vehicles (UAVs), PhenoCams, and Spectral Reflectance Sensors (SRS) over satellite sensors has recently gained significant attention in the field of remote sensing and vegetation phenology. However, exploring different aspects of forest phenology based on observations from these sensors and dr

Alternative Turbulent Trace Gas Flux Measurement Methods

The eddy-covariance (EC) method is the most direct micrometeorological approach to measure the surface–atmosphere trace gases under turbulent conditions. The measurement of trace gas fluxes by eddy covariance requires fast-response instruments (higher than 1 Hz) to measure the turbulent fluctuations of vertical wind velocity and trace gas mixing ratio. For many trace gas species, such fast respons

Efficacy of an ACT and Compassion-Based eHealth Program for Self-Management of Chronic Pain (iACTwithPain) : Study Protocol for a Randomized Controlled Trial

Background: Chronic pain (CP) has serious medical and social consequences and leads to economic burden that threatens the sustainability of healthcare services. Thus, optimized management of pain tools to support CP patients in adjusting to their condition and improving their quality of life is timely. Although acceptance and commitment therapy (ACT) is considered an evidence-based psychological a

Låga nivåer på relativ luftfuktighet och inomhusklimat - Hälsoeffekter samt effekter på mikroorganismers överlevnad

Problemställning: Vad händer vid låga relativa luftfuktighetsnivåer och vilka nivåer bör man åstadkomma? Syfte: Skapa en förståelse av vad som sker vid låga relativa luftfuktighetsnivåer och hur människan påverkas vid dessa nivåer. Vidare ska det även skapas en förståelse för vid vilka RF-nivåer befuktning eventuellt kan vara en lämplig åtgärd med beaktande av de fuktrelaterade risker som kan uppProblem: What happens at low relative humidity levels and what levels should be achieved? Purpose: Create an understanding of what happens at low relative humidity levels and how humans are affected at these levels. Furthermore, an understanding of which RH-levels humidification may be an appropriate measure considering the moisture related risks that may occur. Method: The thesis is a literatur

CSR Communication in Covid-19 — a Case Study of Nordic Aviation Company SAS

Purpose: This paper aims to explore the CSR communication in the natural crisis, with investigation of SAS, a Nordic aviation company who suffers huge negative impact during the pandemic. Methodology /Approach: The paper presents a case study where it uses thematic approach to identify the CSR communication content, then by the light of semiotic analysis, the semiotic analysis is conducted to inte

Uppbörd av skatt och andra förpliktelser – En EU-skatterättslig analys av ett antal lagändringar i SFL som berör utländska företag som bedriver näringsverksamhet i Sverige

Riksdagen har under hösten 2020 antagit de lagförslag som utarbetats i prop. 2019/20:190 Ekonomiskt arbetsgivarbegrepp – förändrade skatteregler vid tillfälligt arbete i Sverige. Den mest omtalade ändringen avser den s.k. 183-dagarsregeln i SINK och övergången från ett formellt till ett ekonomiskt arbetsgivarbegrepp. I propositionen presenterades det även lagförslag som numera innebär kraftigt ökaThe Swedish parliament adopted during the late autumn of 2020 the law proposals that were suggested by the Swedish government in prop. 2019/20:190 Ekonomiskt arbetsgivarbegrepp – förändrade skatteregler vid tillfälligt arbete i Sverige. The most debated topic has been the changes in the so called 183-day rule in SINK and the transition from a formal to an economic employer approach. In the same bi

Rapporteringspliktiga arrangemang - En undersökning om vad det innebär att Skatteverket ska använda inlämnade uppgifter som underlag för skattekontroll

Den 1 juli 2020 infördes ett nytt regelverk gällande rapporteringspliktiga arrangemang i Sverige och i samband med detta infördes även en uppgiftsskyldighet att lämna uppgifter om rapporteringspliktiga arrangemang till Skatteverket. För att ett arrangemang ska vara rapporteringspliktigt ska det vara gränsöverskridande samt innehålla minst ett kännetecken. Ett kännetecken är en egenskap i ett arranOn the July 1, 2020, a new framework of rules regarding reportable arrangements was introduced in Sweden and at the same time a reporting obligation to give information about reportable arrangements to the Swedish Tax Agency (STA) was introduced. For an arrangement to be reportable it must be cross-border and include at least one hallmark. A hallmark is a characteristic in an arrangement which is