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Objective: A widely recognized metabolic side effect of glucocorticoid (GC) therapy is steroid-induced diabetes mellitus (DM). However, studies on the molecular basis of GC-induced pancreatic beta cell dysfunction in human beta cells are lacking. The significance of non-coding RNAs in various cellular processes is emerging. In this study, we aimed to show the direct negative impact of GC on beta c
One of many important features of blue-green infrastructure is the ability to lower flood risks by detention of stormwater. This ability of flood risk reduction has for the first time been evaluated with empirical data in this study. In 2014, Malmö, Sweden, was hit with extreme precipitation corresponding to a return period of 50–200 years that led to severe pluvial flooding. This and other large
Background: The Swedish healthcare is decentralised to 21 regions. Detailed information on all delivered care in the southernmost region, Skåne, is prospectively collected in the Skåne Healthcare Register (SHR). The data is updated daily and hence a good source for epidemiological studies. However, the diagnostic codes used to identify cancer patients in SHR have not yet been validated. Methods: W
Virtual reality headsets, such as the HTC Vive, can be used to model objects, forces, and interactions between objects with high perceived realism and accuracy. Moreover, they can accurately track movements of the head and the hands. This combination makes it possible to provide subjects with precise quantitative feedback on their performance while they are learning a motor task. Juggling is a cha
Aims. Spatial distribution and growth of dust in a clumpy protoplanetary disk subject to vigorous gravitational instability and fragmentation is studied numerically with sub-au resolution using the FEOSAD code. Methods. Hydrodynamics equations describing the evolution of self-gravitating and viscous protoplanetary disks in the thin-disk limit were modified to include a dust component consisting of
Ongoing globalisation combined with the rapid pace of technological change have generated significant growth in economic activities and have improved the welfare and living standards of many people around the world. e opening up of the world economy has also led to unprecedented surges in international trade and has fundamentally transformed the way that goods and services are produced, exchanged
The study has developed an interactive mission benefit analysis (MBA) tool that allows instantaneous evaluation of a range of potential mission designs. The designs are evaluated in terms of their constraint on carbon and water fluxes through calibration of a terrestrial bisphere model. The constraint is quantified by methematically rigorous uncertainty propagation in CCDAS. Applying the MBA tool,
While popular narratives about success in South Africa focus on individual effort, accidents of birth continue to determine life prospects. Inequalities in early childhood development, health, and education narrow the range of possibilities that young people have available to them, and this impacts on their risk appetite, including, through the workings of the maturing brain, a propensity to viole
Despite the controversies that surround the introduction of the third generation (3G) mobile telecommunication systems, the massive investment by industry and the constant demand for new technology and services are expected to usher in its eventual success. WCDMA is a dominant standard in the 3G system designed to succede the highly successful GSM standard. A new technology proposed for WCDMA is a
Swedish alpine and subarctic areas undergo rapid transitions due to climate change, especially in relatively humid areas where the forest vegetation is expanding. It has been suggested that lakes in these areas are in transition from clearwater into brownwater state, because of the humus layer building up in surrounding soils, with negative consequences, e.g., for the biomass production of zooplan
A possible overlap between autism spectrum disorder (ASD) and anorexia nervosa (AN), in terms of both behavioural and cognitive features, has led to new areas of research. The aim of the present study was to examine the occurrence of eating behaviours frequently seen in ASD among adolescents and young adults with AN. The participants were females within the age range 15–25 years: 36 with current A
OBJECTIVES: The aim of this study is to investigate associations between hospitalization for epilepsy and two factors: socioeconomic status and occupation.DESIGN AND SETTING: A nationwide database was constructed in Sweden by linking the Swedish Census to the Hospital Discharge Register to obtain data on all first-time hospitalizations for epilepsy in adults in Sweden during the study period (1987
IMPORTANCE: The clinical utility of stress cardiovascular magnetic resonance imaging (CMR) in stable chest pain is still debated, and the low-risk period for adverse cardiovascular (CV) events after a negative test result is unknown.OBJECTIVE: To provide contemporary quantitative data synthesis of the diagnostic accuracy and prognostic value of stress CMR in stable chest pain.DATA SOURCES: PubMed
Michael Unterguggenberger was raised in semi-poverty, yet grew to make money for the unemployed and destitute. He had no formal education, yet lived to prove an advanced knowledge of money. Shattering economic crisis marked his life, yet he managed to accomplish what many described as an economic miracle. His monetary experiment succeeded in repairing the economic ills of the time, yet was soon ba
This article investigates the impact of climate policies on electoral support for governing parties in Sweden through mixed methods combining a sentiment analysis of news articles and regression discontinuities of voter support over time. The regression discontinuity models indicate that the effects of climate policies on government support are not robust and are spurious across different model sp
När föräldrar väljer att separera från varandra aktualiseras många rättsliga frågor som berör barnet. Föräldrar kan befinna sig i en konfliktfylld situation. Ibland kan konflikten mellan föräldrarna vara så djup att de inte kan komma överens om vem som ska ha vårdnaden om barnen, var barnen ska bo eller hur umgänget med en av föräldrarna ska se ut. De flesta föräldrar kan komma överens om frågornaWhen parents decide to separate from each other many legal issues concerning their child arises. Parents can find themselves in a very contentious situation. Sometimes the conflict can be so deep that the parents cannot agree on who should have custody of the child, where the child will live or how one parents visitation rights should be formed. Most parents can reach an agreement on their own, bu
I media har diskussioner angående förbud mot rasistiska organisationer väckts i samband med att Nordiska motståndsrörelsen (NMR) kandiderar till riksdagsvalet i Sverige, samtidigt som organisationen förbjudits i Finland då den anses sprida hatretorik och legitimera våld. Förespråkare av ett sådant förbud argumenterar att Sverige genom FN:s Internationella konvention om avskaffandet av alla former In the media, discussions about banning racist organizations have been raised in connection with the Nordic resistance movement (NMR) standing as a candidate in the Swedish parliamentary elections, while at the same time the organization has been banned in Finland because it is considered to spread hate and legitimize violence. Advocates of a ban argue that Sweden through the International Convent
