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Capacity shortages in electricity grids can impose significant costs on society due to missed investments in industry. Due to limited profit opportunities and long lead times, grid reinforcements are not a viable solution to the problem, which must therefore be prevented through efficient use of existing grid resources. Local flexibility markets can financially compensate electricity users to shif
The purpose of this report is to evaluate and assess fire safety at Bombardier Arena, located in Västerås. This report will only focus on personal safety and therefore no consideration has been taken regarding economic or environmental damage. Bombardier Arena is used during several events, for example, during concerts, car shows, and different sports activities. The maximum number of attendees at
Background/Problematization: Iconic brands are the gold standard of branding and have established a central role in the consumers’ lives. Behind every iconic brand, we can find iconic products. Despite the importance of these products, iconic products are overlooked in academia. Few studies have explored the concept and there is no common definition or comprehensive framework. This is restrictive
Konflikten i den Syriska Arabiska Republiken började för mer än tio år sedan och ingen lösning är i sikte. Konflikten anses vara den mest dokumenterade konflikten någonsin. Trots att konflikten har pågått under en lång tid saknas det straffrättsligt ansvar för de begångna brotten. Det har gjorts försök, att genom användandet av international straffrätt hänvisa konflikten till den Internationella BThe conflict in the Syrian Arab Republic is ongoing since more than ten years, and there is no end in sight. The conflict is deemed to be the most documented conflict of all time. Despite the longevity of the conflict, there has been a lack of criminal accountability for the crimes committed. The international community has through the use of international criminal law attempted to refer the confl
With the rapid development of Information and Communication Technology (ICT) industry the demand for power has also increased. ICT tends to play a significant role in global greenhouse gas emissions. It was responsible for 10% of world’s total energy consumption in 2010 and is doubling in every 10 years [1]. Cellular networks are among the main energy consumers in the ICT field. To have an environ
Uppsatsen undersöker hur lagreglering av tiggeri har sett ut sedan sent 1800-tal fram till idag i Sverige. Övergripande syfte är att, utifrån ett rättsutvecklingsperspektiv, belysa rättens förändring över tiden. Från medeltiden till tidigt 1800-tal fanns regleringar av tiggeri ämnade att säkra arbetskraft till Sveriges begynnande industrialisering samt förhindra att allmänheten stördes. Syftet änThis thesis examines how statutory regulations of begging have looked like since late 19th century until today in Sweden. The overall purpose is to illustrate the change of regulations over time, from a law development perspective. From the Middle Ages to early 19th century, rules regarding begging existed in order to secure manpower for Sweden’s beginning industrialization and to prevent the pub
The aim of this study was to investigate how the new Non-Invasive Prenatal Diagnosis method (NIPD) is represented within a public policy constituted by The Swedish National Council on Medical Ethics, “SMER”. In order to do this, a post-structural method for policy-analysis called “What’s the problem represented to be”, founded by Carol Lee Bacchi (2009) have been used for the analysis. Through a d
In recent years, overall survival was significantly prolonged in Mantle Cell Lymphoma (MCL) patients due to improved treatment regimen. However, there is still a subgroup of patients that relapse after a short time. Better understanding of the underlying genetic and non-genetic events can be used to achieve personalized medicine for each patient. MCL is associated with the translocation t(11;14)(q
High temperature corrosion presents a challenge both in predicting material loss over time and in cleaning and reusing the material after oxidation cycles. This thesis investigates the oxidation behavior and descaling of different austenitic stainless steels exposed to a range of temperatures in an oxygen-rich environment. The first part of the project focused on developing a descaling method. Tw
Detta kandidatarbete undersöker hur utformningen av en produkt kan förenkla vardagshandling och minska beroendet av bil vid inköp av dagligvaror. Arbetet tar sin utgångspunkt i en målgrupp som lever utan bil, ofta i mindre bostäder, och som upplever svårigheter med att integrera spontana eller nödvändiga inköp i en tidspressad vardag mellan jobb, skola och aktiviteter. Syftet har varit att utvecklThis bachelor’s thesis examines how the design of a product can simplify everyday grocery shopping and reduce car dependency. The project focuses on a target group that lives without a car, often in smaller apartments, and faces challenges integrating spontaneous or necessary purchases into a time-pressed daily schedule of work, school, and activities. The aim has been to develop an aid that facil
The darknet cryptomarkets marked an evolution in the drug trade by providing technological anonymity and security for both sellers and buyers. Together with their surrounding forums, they form an ecosystem where participation and access to its safety and harm reduction benefits depend on digital capital, a resource that is not equally available to all. This study examines how digital capital influ
Background: Climate change can directly affect human health by varying exposure to non-optimal outdoor temperature. However, evidence on this direct impact at a global scale is limited, mainly due to issues in modelling and projecting complex and highly heterogeneous epidemiological relationships across different populations and climates. Methods: We collected observed daily time series of mean te
In KEYNOTE-564, adjuvant pembrolizumab, a PD-1 antibody, significantly improved disease-free survival (DFS) in localised clear-cell renal cell carcinoma (ccRCC) with a high risk of relapse. In 2021, the European Association of Urology RCC Guidelines Panel issued a weak recommendation for adjuvant pembrolizumab for high-risk ccRCC as defined by the trial until final overall survival data and result
Current derivatization-dependent approaches for amino acid composition analysis of cereal proteins have significant variability due to lack of direct analysis opportunities and loss of amino acids during protein-hydrolysis. To tackle these drawbacks, a novel direct, derivatization-free approach was successfully introduced, using HPAEC-PAD, and applied for analysis of hydrolyzed defatted oat flour
Background: The estrogen receptor (ER) can change expression between primary tumor (PT) and distant metastasis (DM) in breast cancer. A tissue biopsy reflects a momentary state at one location, whereas circulating tumor cells (CTCs) reflect real-time tumor progression. We evaluated ER-status during tumor progression from PT to DM and CTCs, and related the ER-status of CTCs to prognosis. Methods: I
PURPOSE: Reliable molecular diagnostic tools are still unavailable for making informed treatment decisions and monitoring the response in patients with castration resistant prostate cancer. We evaluated the significance of whole blood circulating androgen receptor transcripts of full length (AR-FL) and splice variants (AR-V1, AR-V3 and AR-V7) as biomarkers of abiraterone acetate treatment resistan
Viruses are infections species that infect a large spectrum of living systems. Although displaying a wide variety of shapes and sizes, they are all composed of nucleic acid encapsulated into a protein capsid. After virions enter the host cell, they replicate to produce multiple copies of themselves. They then lyse the host, releasing virions to infect new cells. High proliferation rate of viruses
In order to effectively tackle the on-going changes in global climate, stakeholders and policy makers across the globe need timely and accurate information they can trust on a wide range of topics. Here we briefly describe how observational data on greenhouse gas concentrations collected from the ICOS network of measurement stations in Europe is transformed via atmospheric modelling into informati
Background Allogeneic stem cell transplantation (SCT) enhances coagulation via endothelial perturbation and inflammation. Role of natural anticoagulants in interactions between coagulation and inflammation as well as in acute graft-versus-host disease (GVHD) are not well known. The purpose of this study was to define changes in natural anticoagulants over time in association with GVHD. Patients an
