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The mitochondrial protein frataxin plays a central role in mitochondrial iron homeostasis, and frataxin deficiency is responsible for Friedreich ataxia, a neurodegenerative and cardiac disease that affects 1 in 40000 children. Here we present a single-particle reconstruction from cryoelectron microscopic images of iron-loaded 24-subunit oligomeric frataxin particles at 13 and 17 angstrom resolutio

BACKGROUND: The method of treatment of aortic valve stenosis in early infancy is still controversial. This study was performed to evaluate short-term and long-term outcome in our center during a 14-year period.METHODS: Between 1991 and 2004, 64 consecutive patients younger than 3 months old underwent open surgical commissurotomy because of aortic valve stenosis. Median age was 18 days (range, 1 to

Objectives The aim of the present study was to test whether construction workers, who are known to have a relatively higher risk of cardiovascular disease (CVD), had higher concentrations of cortisol in saliva and a lower relative variability when compared with white-collar workers. Methods Data from two groups of male construction workers with physically demanding job assignments, with either reg

The aim of this study was to determine the threshold of fracture probability at which interventions became cost-effective in women based on data from the UK. We modelled the effects of an intervention costing pound350 per year given for 5 years that decreased the risk of all osteoporotic fractures by 35% followed by a waning of effect (offset time) for a further 5 years. Sensitivity analyses inclu

Objective: The aim of current study was to evaluate the changes of health-related quality of life (HRQoL) and its clinical, demographic and socioeconomic determinants during chemotherapy and 4 months follow-up in women with breast cancer using a repeated measures framework. Methods and Materials: A double blind cohort study was performed in 100 breast cancer patients given fluorouracil, doxoru

Objective: Compare perioperative course and long-term mortality after liver resection for colorectal cancer (CRC) metastases between patients who had preoperative treatment with portal vein embolization (PVE) and chemotherapy or chemotherapy alone. Methods: Among patients undergoing liver resection for CRC metastases following preoperative chemotherapy treatment, 17 patients who had received pre

Characterization of directed differentiation of pluripotent stem cells towards therapeutically relevant cell types, including pancreatic beta-cells and hepatocytes, depends on molecular markers and assays that resolve the signature of individual cells. Pancreas and liver both have a common origin of anterior definitive endoderm (DE). Here, we differentiated human embryonic stem cells towards DE us

PURPOSE: The purpose of this study is to investigate the results of first-time surgery for sporadic primary hyperparathyroidism (pHPT) in patients with preoperatively negative sestamibi scintigraphy and ultrasound. METHODS: Data were gathered prospectively in a multicenter database for quality control in parathyroid surgery. Between 2004 and 2008, 3,158 patients underwent first-time surgery for sp

Background: Recent studies show that FVIIa binds to endothelial cell protein C receptor (EPCR) on vascular endothelium; however, the importance of this interaction in hemostasis or pathophysiology is unknown. Objective, The aim of the present study is to investigate the role of FVIIa interaction with EPCR on the endothelium in mediating FVIIa transport from the circulation to extravascular tissues

The objective of this paper is twofold. First, against the background of an existing empirical literature on the duration of trade which has found that international trade is often of strikingly short duration, we aim to establish whether or not EU imports from the rest of the world also are short-lived. Second, since there is at this point no clear commonly accepted theoretical explanation for th

Cultural values and beliefs within the jazz community have intrigued social scientists for a long time. Being one of the oldest recognised subcultures, jazz has been celebrated for its socio-political ambitions as well as the complexity and aesthetics of the music itself. Being recognised as an outlet for fighting social injustices throughout history, the notable exclusion of female jazz musicians

The transition from InterBank Offered Rates (IBORs) to Risk-Free Rates (RFRs) represents one of the most significant shifts in modern financial markets. This transition addresses concerns about the reliability and transparency of IBORs by adopting benchmarks based on actual market transactions. However, this change has far-reaching implications for the valuation of complex financial instruments, s

Sverige har genomfört en ny lagreform som möjliggör användandet av anonyma vittnen. Syftet med lagen är att stärka vittnesskyddet och bryta tystandeskulturen inom kriminella miljöer för att förbättra möjligheterna att klara upp brott. Lagändringen innebär en stor förändring över hur den svenska rättstillämpningen har sett ut innan och väcker många frågor om rättssäkerhet. Uppsatsen undersöker vadSweden has implemented a new law that allows the use of anonymous wit-nesses. The purpose of the legal form is to strengthen witness protection and break the culture of silence within criminal environments, thereby im-proving the ability to solve crimes. This legal reform represents a signifi-cant shift in how Swedish law has previously been applied and raises many questions about legal certainty.

Klimatpåverkan och dess effekter är ett högaktuellt ämne för alla branscher och industrier särskilt för bygg- och fastighetsbranschen som år 2021 stod för 22% av utsläppen av växthusgaser i Sverige (Boverket, 2024a). Visserligen har det skett en minskning av utsläppen för branschen sedan 2008 men behovet av att bygga nya bostäder är stort samtidigt som byggkostnaderna i Sverige blir dyrare och dyrThe impact of climate change and its effects is a current topic for all industries, especially the construction and real estate sectors, which accounted for 22% of greenhouse gas emissions in Swedenin 2021 (Boverket, 2024a). Although emissions from the sector have decreased since 2008, the need for new housing is significant, and construction costs in Sweden are rising more and more every year. T

Critical-sized bone defects remain a significant unmet clinical need, with > 500,000 reconstructive procedures performed annually in the United States and Europe and associated costs exceeding US$3 billion. Autologous bone grafting—the current gold standard—suffers from limited harvest volume and donor-site morbidity, whereas allografts show variable integration and carry immunological and infecti

Background: Systecon is a leading European consultancy and software company within system logistics, system reliability, maintenance and Life Cycle Cost (LCC) analysis. Historically the military and military suppliers have accounted for the majority of the commissions, but over time other industries have realized that effective maintenance and logistic support can greatly enhance the overall effec

Alloimmunization against the RhD antigen is the most common cause of hemolytic disease of the fetus and newborn. Antenatal anti-D prophylaxis in addition to postnatal anti-D prophylaxis reduces the number of RhD-immunizations compared to only postnatal administration. Cell-free fetal DNA released from the apoptotic trophoblastic placental cells into the maternal circulation can be used to determin

With the increased availability of computational resources, the past decade has seen a rise in the use of computational fluid dynamics (CFD) for medical applications. There has been an increase in the application of CFD to attempt to predict the rupture of intracranial aneurysms, however, while many hemodynamic parameters can be obtained from these computations, to date, no consistent methodology