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G. Karlsson group Our ResearchThe production of blood cells, hematopoiesis, is maintained by a small number of hematopoietic stem cells (HSCs) that have the capacity to differentiate into all hematopoietic lineages, and at the same time self-renew to maintain the HSC pool. These properties make HSCs essential for maintaining hematopoietic homeostasis and for reconstitution of patients during treat
https://www.stemcellcenter.lu.se/research-groups/gkarlsson - 2026-05-31
We investigate the prognostic significance of the pro-angiogenic cytokine vascular endothelial growth factor (VEGF), urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor 1 (PAI-1), and S-phase fraction (SPF) for distant disease free survival (DDFS) in 219 premenopausal patients with node-negative breast cancer (NNBC). In univariate analysis significantly shorter DDFS was obs
Popular Abstract in Swedish ”Vi kommo överens om att möten innehålla alla livets möjligheter, och att en människa som levat mycket vet mycket om möten om hon alls vet någonting.” Så uttalar den kvinnliga huvudpersonen i Mannen vid min sida (1933) sin övertygelse efter mötet med älskaren. Denna avhandling fokuserar mötet i Elin Wägners trettiotalsromaner. Genom att analysera detta vill avhandlingsfThe aim of this present thesis is to present the Utopian scheme in Elin Wägner’s novels of the nineteen-thirties: Dialogen fortsätter (1932) (“The Dialogue Continues”), Mannen vid min sida (1933) (“The Man by my Side”), Genomskådad (1937) (“Unmasked”) and Hemlighetsfull (1938) (“Mysterious”). With her authorship Wägner was aiming for a new social order, a radical change, polväxling (a shift of pol
Not all people with severe mental illness who attend Individual Placement and Support (IPS) gain and keep their jobs or work full time. Research has indicated a relationship between social disabilities and work performance in this group, and that support provided is often directed towards the social work environment. However, relationships between social skills performed in an authentic work setti
The equilibrium self-assembly of cationic surfactants in bulk solution and at negatively-charged silica substrates is investigated experimentally and theoretically. The surfactants used are quaternary ammonium salts, both monovalent (DoTAB, TTAB, CTAB) and divalent (DoPPDAC). The adsorption of DoPPDAC to silica, in the absence or presence of added electrolyte, is studied with the technique of null
Most of the decisive molecular events in biology take place at the protein-water interface. The dynamical properties of the hydration layer are therefore of fundamental importance. To characterize the dynamical heterogeneity and rotational activation energy in the hydration layer, we measured the 17O spin relaxation rate in dilute solutions of three proteins in a wide temperature range extending d
That data from polar orbiting satellites have detected a widespread increase in photosynthetic activity over the last 20 years in the grasslands of the Sahel is justifies investigating its role in the tropical carbon cycle. But this task is undermined because ground data that are generally used to support the use of primary production models elsewhere are lacking. In this paper, we profile a Light
A fully automatic system for abdominal organ segmentation is presented. As a first step, an organ localization is obtained via a robust and efficient feature registration method where the center of the organ is estimated together with a region of interest surrounding the center. Then, a convolutional neural network performing voxelwise classification is applied. Two convolutional neural networks o
Several studies have now shown that chronic myeloid leukaemia (CML) patients in deep molecular remission may discontinue tyrosine kinase inhibitor (TKI) treatment with a treatment free remission (TFR) rate of approximately 40–60 %. Some factors influencing the possibility of TFR have been described but better tools are needed for individual prediction of long-term TFR. Herein, two multiplex panels
Background: Potent antithrombotic therapy has significantly improved prognosis for patients with acute myocardial infarction (AMI), however, at a price of increased bleeding risk. Chronic gastric infection with Helicobacter pylori (Hp) commonly causes upper gastrointestinal bleeding and is proposed as a risk factor for subsequent bleeding post AMI. The prevalence of active Hp in a current AMI popu
Colorectal cancer (CRC) is the third most common cancer worldwide. Increasing evidence suggests that CRC should be considered a heterogeneous disease, with multiple differences between proximal and distal tumours. The immune system may, depending on the context, promote or inhibit tumour growth, and different immune cell subsets have been found to be associated with impaired or improved prognosis
Test application and test design, performed to ensure the production of fault-free chips, are becoming complicated and very expensive, especially in the case of SoCs (System-on-Chip), as the number of possible faults in a chip is increasing dramatically due to the technology development. It is therefore important to take test design into consideration as early as possible in the SoC design-flow in
The interest for effective preventive strategies for slips and falls is growing. Much remains to be done, however, to prevent slips and falls in the traffic environment. Some pedestrians are injured because of slippery pavements and roadways. Using an appropriate anti-skid device may reduce the risk of slips and falls on different surfaces outdoors during winter. The aim of this study was to evalu
This paper deals with a two-echelon spare parts inventory system with one central warehouse and a number of local warehouses facing Poisson demand. Normally, the local warehouses replenish stock from the central warehouse. However, if a demand cannot be satisfied within a pre-determined time window, an emergency shipment is requested from an outside supplier. Moreover, as in practice, this outside
Glycosaminoglycans (GAGs) are polysaccharides produced by essentially all mammalian cells. Due to their enormous structural diversity, they are involved in many biological processes both in health and disease, including all stages of tumor progression. GAGs are normally attached to a core protein as a part of a proteoglycan; however, GAG biosynthesis can be induced by compounds composed of a xylos
Molecular dynamic simulations inevitably demand large computational resources for structures of liner measures even as small as a few tens or hundreds of nanometers. Thus, a computationally efficient method to simulate larger structures and, at the same time, retain the properties and the mechanical response at the atomic scale is in demand. One such approach is peridynamics, which is a nonlocal e
Considerable progress in the investigation of the electronic and vibrational properties of atoms, molecules, materials, surfaces and interfaces has been achieved by combining different photon sources of complementary characteristics. In this paper some experimental results obtained recently at LURE by using two synchronized sources, such as the IR free-electron laser (FEL) CLIO, the VUV storage ri
