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Objective Overproduction of cell-free fetal hemoglobin (HbF) in the preeclamptic placenta has been recently implicated as a new etiological factor of preeclampsia. In this study, maternal serum levels of HbF and the endogenous hemoglobin/heme scavenging systems were evaluated as predictive biomarkers for preeclampsia in combination with uterine artery Doppler ultrasound. Study design Case-control
To increase the market share of hybrid vehicles within the automotive industry, it is necessary to minimize the cost increase related to the hybridization. In this context a methodology to estimate the cost of the electrical machine and transmission is developed. Insights on the selection of a cost effective electrical machine topology are provided and the benefits and disadvantages of different d
The introduction of smart phones has redefined the usage of mobile phones in the communications world. Smart phones are now equipped with various sophisticated features such as Wi-Fi, Global Positioning System (GPS) navigation capability, high-resolution camera, touch screen, and broadband access which helps the mobile phone users to stay connected and updated. Many of these features are primarily
Several genetic studies have demonstrated an association between mutations in glucocerebrosidase (GBA), originally implicated in Gaucher's disease, and an increased risk of Parkinson's disease (PD). We have investigated the possible involvement of genetic GBA variations in PD in the Swedish population. Three GBA variants, E326K, N370S, and L444P were screened in the largest Swedish Parkinson cohor
In information systems security, the objectives of risk analysis process are to help to identify new threats and vulnerabilities, to estimate their business impact and to provide a dynamic set of tools to control the security level of the information system. The identification of risk factors as well as the estimation of their business impact require tools for assessment of risk with multi-value s
We study a design framework for robust, independently verifiable, and workload-balanced distributed algorithms working on a common input. The framework builds on recent noninteractive Merlin--Arthur proofs of batch evaluation of Williams~[31st IEEE Colloquium on Computational Complexity (CCC'16, May 29-June 1, 2016, Tokyo), to appear] with the basic observation that Merlin's magic is not needed fo
We study System Optimum Dynamic Traffic Assignment (SO-DTA) for realistic traffic dynamics controlled by variable speed limits, ramp metering, and routing controls. We consider continuous-time cell-based Dynamic Network Loading models that include the Cell Transmission Model with FIFO rule at the diverge junctions as well as non-FIFO diverge rules. We consider SO-DTA formulations in which the tota
The sky roller ride depends on interaction with the air to create a rolling motion. In this paper, we analyse forces, torque and angular velocities during different parts of the ride, combining a theoretical analysis, with photos, videos as well as with accelerometer and gyroscopic data, that may be collected e.g. with a smartphone. For interpreting the result, it must be taken into account that t
Multiple exciton generation (MEG) is a process in which more than one electron hole pair is generated per absorbed photon. It allows us to increase the efficiency of solar energy harvesting. Experimental studies have shown the multiple exciton generation yield of 1.2 in isolated colloidal quantum dots. However real photoelectric devices require the extraction of electron hole pairs to electric con
Low latency signal processing and high throughput implementations are required in order to realize real-time TDD massive MIMO communications, especially in high mobility scenarios. One of the main challenges is that the up-link and down-link turnaround time has to be within the coherence time of the wireless channel to enable efficient use of reciprocity. This paper presents a hardware architectur
Stanniocalcin-1 (STC-1) is a nerve cell-enriched protein involved in intracellular calcium homeostasis regulation. Changes in calcium regulation are hypothesized to play a role in the pathophysiology of Alzheimer's disease (AD). The expression of STC-1 increases in response to ischemic stroke, but whether it is altered in neurodegenerative disorder, particularly Alzheimer's disease (AD), has not b
Background: Sonographers' perceptions of ergonomic and work-related pain problems at work have so far mostly been researched in quantitative studies by questionnaires. There is a need of experience-based research to deepen the knowledge about how sonographers perceive ergonomic problems at work. Therefore, the aim of this qualitative study was to describe sonographers' perceptions of ergonomic pro
The levels of protein kinase C-γ (PKC-γ) and the calcium/calmodulin-dependent kinase II-α (CaMKII-α) were measured in crude synaptosomal (P2), particulate (P3), and cytosolic (S3) fractions of the neocortex of rats exposed to 1-hour and 2-hour middle cerebral artery occlusion (MCAO) and 2-hour MCAO followed by 2-hour reperfusion. During MCAO, PKC levels increased in P2 and P3 in the most severe is
Background Calcium imaging is based on the detection of minute signal changes in an image time-series encompassing pre- and post-stimuli. Depending on the function of the elicited response, change may be pronounced, as in the case of a genetically encoded calcium-reporter protein, or subtle, as is the case in a bath-applied dye system. Large datasets are thus often acquired and appraised only duri
This paper describes a heterogeneous competitive flow immunoassay with a high sample throughput which can be used for the screening of smaller analytes in various samples. The method is based on off-line incubation of the analyte (Ag), a fluorescent labelled tracer (Ag*) and the corresponding antibody (Ab). The separation of bound (Ab-Ag*) and free tracer (Ag*) is based on a size exclusion and rev
This paper proposes an IV-based panel unit root test that is general enough to accommodate general error serial and cross-section dependence, and a potentially nonlinear deterministic trend function. These allowances make the new test one of the most general around. It is also very simple to implement. Indeed, the IV statistic is asymptotically invariant to not only to all nuisance parameters char
This paper describes an American Monte Carlo approach for obtaining fast and accurate exercise policies for pricing of callable LIBOR Exotics (e.g., Bermudan swaptions) in the LIBOR market model using the Stochastic Grid Bundling Method (SGBM). SGBM is a bundling and regression based Monte Carlo method where the continuation value is projected onto a space where the distribution is known. We also
