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Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new lo
Neurons with internal memory have been proposed for biological and bio-inspired neural networks, adding important functionality. We introduce an internal time-limited charge-based memory into a III-V nanowire (NW) based optoelectronic neural node circuit designed for handling optical signals in a neural network. The new circuit can receive inhibiting and exciting light signals, store them, perform
Background: Patients with bacteraemia caused by gram-positive bacteria are at risk for infective endocarditis (IE). Because IE needs long antibiotic treatment and sometimes heart valve surgery, it is very important to identify patients with IE. Objectives: In this narrative review we present and discuss how to determine which investigations to detect IE that are needed in individual patients with
Constructed wetland (CW), a green wastewater treatment technology, is extensively used in the world owing to its advantages of less investment, low energy consumption, simple operation and maintenance, and satisfactory purification effect. Currently, with the promotion of CW application, a variety of problems have been gradually exposed. This paper summarizes the common problems of CWs, including
During the past decade, cognitive neuroscience has been calling for population diversity to address the challenge of validity and generalizability, ushering in a new era of population neuroscience. The developing Chinese Color Nest Project (devCCNP, 2013–2022), the first ten-year stage of the lifespan CCNP (2013–2032), is a two-stages project focusing on brain-mind development. The project aims to
Background: Insomnia is common in adolescents. This study evaluated feasibility and preliminary efficacy of a six-week internet-delivered cognitive-behavioral therapy for insomnia (ICBT-I) in adolescents. Methods: In this uncontrolled pilot study, participants (n = 27, 78% female) completed assessments pre- and post intervention. Data on recruitment, adherence to treatment, treatment activity, sat
It is important for utilities to plan for Distributed Energy Resources (DER) uptake by representing and modelling their characteristics using appropriate assumptions, methods and tools. Large-scale DER deployment impacts power flows and power system performance in various complex ways as well as potentially contributing to ancillary services. In this paper, we explore state of the art planning me
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To determine the effects of methylxanthines (caffeine; theophylline or aminophylline) and 'no methylxanthine administration' on morbidity and mortality in preterm infants, using network meta-analysis.
The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses a severe threat to humanity and demands the redirection of scientific efforts and criteria to organized research projects. The international COVID19-NMR consortium seeks to provide such new approaches by gathering scientific expertise worldwide. In particular, making available viral proteins and RNAs will pave th
Pentachlorophenol (PCP) is a commonly found recalcitrant and toxic groundwater contaminant that resists degradation, bioaccumulates, and has a potential for long-range environmental transport. Taking proper actions to deal with the pollutant accounting for the life cycle consequences requires a better understanding of its behavior in the subsurface. We recognize the huge potential for enhancing de
Epstein Barr Virus (EBV) has been recognized for its ability to transform B lymphocytes and for its association with different types of cancers including Hodgkin lymphoma. In addition, EBV may also modulate the microenvironment of HL. In this study, we aimed to investigate the prevalence of EBV among HL cases in Ethiopia and to assess the tissue cellular composition of EBV-related and EBV-unrelate
Fossil fuel subsides are estimated to between 523‐1900 billion USD per year, depending on how subsidies are defined. Phasing out fossil fuel subsides is therefore considered a first best solution towards more sustainable energy systems and making progress on fossil fuel subsidy reform has a big potential for climate change mitigation. Also in Sweden that has among the highest environmental taxes i
The goal of this master thesis is to set up a low cost automated robotic test system which can later be reproduced to greatly increase test coverage. Mostly through experimental research this thesis will find good components to use and evaluate these from a performance and cost perspective. It will also develop computer vision algorithms needed and automation software for the final set up. The per
As the Union Customs Code will replace the Community Customs Code with effect from 1 May 2016, the thesis focuses on the new treatment of royalty payments for customs purposes and its legal consequences. In a first step, a comparison between the Community Customs Code and the Union Customs Code reveals that importers will have to face a significant increase in the customs liability of royalty pa
Med ofta stora summor involverade i ärenden relaterade till osäkra hamnar är det av stort intresse för både redaren och befraktaren att etablera deras respektive risk de har under en resa. Den här uppsatsen behandlar relationen mellan redaren och befraktaren då redaren har åsamkats skada på grund av en osäker hamn. Frågan är till vilken grad det är möjligt att hålla befraktaren ansvarig för en såWith often large amounts involved, the issue of unsafe ports is of great interest for both the shipowner and the charterer in order to establish what kind of risk they would bear under a voyage. This thesis deals with the relationship between the shipowner and the charterer when the shipowner has suffered a loss due to an unsafe port. The question is to what extent it is possible to hold the char
This thesis explores the interlinking of evaluation and development through an anthropological lens by considering the indigenization process of an evaluation culture, and how evaluation travels across boundaries as an assemblage, similar to many other global phenomena. Central to the thesis is the national evaluation capacity building trend viewed as a two-sided project; first as internal capacit
The aim of this master thesis has been to develop a Blocking device that makes sure that a Spring parking brake is not unintentionally activated after a manual release. There is also a need for developing a new Piston indicator that should give two signals depending on if the Spring parking brake is active or inactive. Both are supposed to fit with a completely new generation of Spring parking bra
