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Novel strategies for specific tumour cell targeting are necessary in order to improve survival rates and to reduce side effects of current therapies in cancer patients. Hypoxia is a hallmark of solid tumours and one of the major driving forces for tumour progression. Targeting of the adaptive responses of cancer cells to hypoxia offers opportunities for tumour specific therapies. The aim of this
Generalized lock-in amplifiers use digital cavities with Q-factors as high as 5 × 108 to measure signals with very high precision. In this Note, we show that generalized lock-in amplifiers can be used to analyze microwave (giga-hertz) signals with a precision of few tens of hertz. We propose that the physical changes in the medium of propagation can be measured precisely by the ultra-high precisio
Aims: Type 1 diabetes mellitus is associated with increased fracture risk, whereas the risk associated with type 2 diabetes is less obvious. Elevated fasting blood glucose (FBG) and high 2-hour glucose during an oral glucose tolerance test (OGTT) indicate impaired glucose tolerance or diabetes. The associations between FBG, 2-h glucose and the risk of fracture were investigated. Methods: The Malmö
Time perspective (TP) refers to individuals’ ways of constructing, reconstructing, and relating the psychological concepts of past, present,and future, and provides individuals with a coherence of experiences over time. In the present study, the relationships among five TPs (past negative, past positive, present fatalistic, present hedonistic, and future) were studied in a student sample (N = 280)
Many patients on renal replacement therapy (RRT) require parathyroidectomy (PTX). Trends and current rates of PTX on a national level are not known. Furthermore, it is not completely clear which factors influence rates of PTX. Thus, our aim was to investigate the incidence, regional distribution and factors associated with PTX as well as possible temporal changes, in the Swedish RRT population.
Platelet-derived growth factor receptors (PDGFR) alpha and beta have been suggested as potential targets for treatment of rhabdomyosarcoma, the most common soft tissue sarcoma in children. This study identifies biologic activities linked to PDGF signaling in rhabdomyosarcoma models and human sample collections. Analysis of gene expression profiles of 101 primary human rhabdomyosarcomas revealed el
Objectives To determine the causes and predictors of mortality in systemic sclerosis (SSc). Methods Patients with SSc (n=5860) fulfilling the American College of Rheumatology criteria and prospectively followed in the EULAR Scleroderma Trials and Research (EUSTAR) cohort were analysed. EUSTAR centres completed a structured questionnaire on cause of death and comorbidities. Kaplan-Meier and Cox pro
Symmetry breaking is a crucial technique in modern combinatorial solving, but it is difficult to be sure it is implemented correctly. The most successful approach to deal with bugs is to make solvers certifying, so that they output not just a solution, but also a mathematical proof of correctness in a standard format, which can then be checked by a formally verified checker. This requires justifyi
It is intuitive and well known, that if agents in a multi-agent system iteratively update their states in the Euclidean space as convex combinations of neighbors’ states, all states eventually converge to the same value (consensus), provided the interaction graph is sufficiently connected. However, this seems to be also true in practice if the convex combinations of states are mapped or radially p
In this paper, we present three studies in which we develop and test different representations of intonation contours and prosodic stress with the aim to provide foreign language learners with a notation that they can easily interpret. Study I addresses learners’ productions of target intonation based on six common notation systems. The results reveal how learners themselves make sense of the diff
When a child's parents are divorced or separated and violence has occurred between them, several problems can arise in custody cases. The purpose of this thesis is to study these problems and the possibilities to solve them. The first problem I study in this thesis is the different parties' rights which often rise in opposition to one other. These rights refers to the abused parent's r
En av de stora utmaningarna inom den internationella handelsrätten idag är hur man ska kunna förbättra situationen för utvecklingsländer inom den internationella handeln. Denna uppsats belyser specifika undantagsregler, inom WTO-rätten, som har till ändamål att öka utvecklingsländers möjligheter att delta i den internationella handeln. Industriländer tilldelar utvecklingsländer, i enlighet med WTOOne of the current challenges within the field of international trade law is how to meet the special needs of developing countries and how to a greater extent include these countries in the world trading system. This thesis examines a particular set of exception rules that exist on behalf of developing countries. Developing countries are, in accordance with WTO law, granted different tariff prefer
This bachelor thesis analyses the impact that development projects working with higher education and micro-credit have on youth’s empowerment processes. I have made a minor field study in Kenya and conducted 21 semi-structured respondent interviews with a group with higher education, a group that was provided with micro-credit and a group which was not provided with neither. The interviews were co
Denna uppsats behandlar ingående hur officialprincipen tillämpas i de svenska migrationsdomstolarna. Uppsatsen tar, efter en kort introduktion till migrations- processen i Sverige, avstamp i en förvaltningsprocessuell diskussion kring vad som omfattas av en förvaltningsdomstols utredningsskyldighet. Olika faktorer som påverkar utredningsskyldigheten tas upp. Därefter övergår uppsatsens fokus till This essay discusses in detail how the ex officio inquiry principle (“officialprincipen”) is applied in the Swedish migration courts. After a brief introduction to the Swedish migration process, a general discussion concerning what is covered by an administrative court’s obligation to investigate is performed. Various factors that affect this obligation are discussed. Focus then shifts towards how
This study maps the intersection of homelessness and migration in Europe by focusing on Italy and Sweden; in the study, ‘Europe’ is defined by the Schengen Common Area Agreement, by the Common European Asylum System and by the Dublin Regulation. Using Kimberlé Crenshaw’s Intersectionality as one of its main theoretical reference points, the study argues that different dimensions of power relations
This thesis aimed to work with different techniques of building archaeology, both traditional and digital. The goal was to define the possibilities offered by the “traditional” and the “digital” building archaeology but also to show the limits of these two methods. The main issue of discussing methodological problems in building archaeology was the need to define digital building archaeology, espe
Jag har analyserat huvud- och spårelementkoncentrationer i plagioklas från en norit-anortositintrusion, Älgön, Hakefjorden vid Sveriges västkust med syfte att fastställa intrusionens magmatiska ursprung, magmans utveckling och dess transport upp genom jordskorpan. Megakrister av plagioklas i anortositen har en homogen fördelning med avseende på huvud- och spårelement medan plagioklas-megakrister iMajor and trace element data taken from plagioclase crystals from anorthosites and related rock units in the Hakefjorden Complex located off the west coast of Sweden were investigated for the purposes of constraining magma chamber processes and the source of the magma. Although the anorthosite units were completely homogenous in regards to its chemistry, the plagioclase in the associated norite an
Research Purpose The concept of strategic thinking is vague in the previous literature, and we lack an understanding of what strategic thinking is. The purpose of this thesis is to contribute towards the understanding of the cognitive elements or components in strategic thinking. To fulfil this purpose, we aim to collect survey and interview data from students studying Computer Science and Enginee
