Filetype
A model membrane system based on lipid lyotropic phases confined inside the pores of a well-defined scaffold membrane, thereby forming a double-porous membrane structure, is described. The model membrane system is characterized with regard to lipid structure, lipid location, and phase transitions, using small-angle X-ray scattering, differential scanning calorimetry, and confocal microscopy. The s
The complex structure-activity correlation of the CO oxidation on ruthenium has been studied in a batch reactor by using in situ surface X-ray diffraction (SXRD) and on-line mass spectrometry. Two distinct active phases are identified at higher pressures in the mbar range depending on the reaction conditions: a non-oxidic phase and a RuO2(1 1 0) layer of variable thickness ranging from 1.5 nm to 1
This paper focuses on the issue plasticity within the framework of a micromechanical model for single-crystal shape-memory alloys. As a first step towards a complete micromechanical formulation of such models, we work with classical J(2)-von Mises-type plasticity for simplicity. The modeling of martensitic phase transitions is based on the concept of energy relaxation (quasiconvexification) in con
This study examined variability of lip movements across repetitions of the same utterance as a function of age in Swedish speakers. The specific purpose was to extend earlier findings by examining variability in both phase and amplitude. Subjects were 50 typically developed native Swedish children and adults (28 females, 22 males, aged 5-31 years). Lip movements were recorded during 15-20 repetiti
The homolytic Co-C bond dissociation energy (BDE) is central to the understanding of the function of vitamin B12, an important coenzyme of many proteins. We investigate why earlier density functional (B3LYP) estimations of the BDE in methylcobalamin have given so poor results (91-117 kJ/mol) compared to the experimental estimate (155 ± 13 kJ/mol). Improving the basis set increases the discrepancy,
In search for a possible explanation of the phenotypic heterogeneity in selective immunoglobulin (Ig)A deficiency, we studied the IgG2 antibody response to meningococcal polysaccharide A (PSA) in IgA-deficient (IgAd) individuals after vaccination with meningococcal A + C polysaccharide vaccine. Two groups of IgAd individuals, one frequently infected and one clinically apparently healthy, as well a
Previously, time/temperature treatments of starch have been performed mainly on starch/water systems. In this study the same time/temperature treatments were applied to starch/water systems and to potato starch in situ. Two potato varieties (Solanum tuberosum cultivars Asterix and Bintje) were used. The effect of time/temperature treatments on gelatinisation behaviour was evaluated using different
A general approach to exploratory analysis and modeling of network data is to investigate dyad distributions. We discuss clustering of dyad distributions when there are several variables defined on the vertices, and these variables interact with the arc values of the network. As an illustration we use data on achievement, race, sex and friendship for children in 48 different school classes. A clus
The kinetics of dipolar nonradiative energy transfer (DET) between dyes confined to the core−corona interface region of poly(isoprene-b-methyl methacrylate) block copolymers (PI−PMMA) in acetonitrile was analyzed using a new distribution model for energy transfer in spherical micelles. The distribution of block junction points was described by the model of Helfand and Tagami (HT) for the strong se
Repeated exposures to both microbial and innocuous Ags in vivo have been reported to both eliminate and tolerize T cells after their initial activation and expansion. The remaining tolerant T cells have been shown to suppress the response of naive T cells in vitro. This feature is reminiscent of natural CD4+CD25+ regulatory T cells. However, it is not known whether the regulatory function of in vi
Fluctuations in the fluorescence polarization degree and direction are reported for the first time for single conjugated polymer molecules embedded in a polystyrene matrix at room temperature. The polymer molecule, a polythiophene derivative, clearly emits as a multi-chromophore ensemble showing that the energy does not funnel to any specific low-energy trap. The fluorescence instead originates fr
In this work, we describe the application of a sorption calorimeter to study the binary system n-octyl beta-D-glucoside/water at 25, 40, and 60 degreesC. At 25 degreesC we also carried out experiments with heavy water which showed similar results to those with normal water. The method used allows one to simultaneously obtain information about the activity of water and the enthalpy of mixing in bin
Theoretical results are presented on the absorption and fluorescence of indole in aqueous solution as well as at the air/water surface. We use a combined quantum chemical statistical mechanical model with explicit solvent. An approximate ab initio complete active space self-consistent field description of the indole molecule is used, coupled to a discrete polarizable water medium. From the bulk si
Anti-proliferative drugs have been used for immunosuppression since the introduction of clinical transplantation. Most transplant centres include azathioprine (Aza) and cyclosporine (CyA) in their standard regimens, despite several controlled studies having failed to confirm the benefit of this combination. Aza is still. the most commonly used anti-proliferative drug, although no major differences
We show how a difference in the correlation length longitudinally and transversely, with respect to the jet axis in e+e− annihilation, arises naturally in a model for Bose-Einstein correlations based on the Lund string model. In genuine three-particle correlations the difference is even more apparent and they provide therefore a good probe for the longitudinal stretching of the string field. The c
Only a small number of protein homologues cause the majority of allergies. There is no consensus structure or other obvious common denominator discriminating the few proteins that are allergens from thousands of other, non-allergenic proteins. By database sequence homology searching, we here show that to date known allergen sequences have no or few bacterial homologues, in contrast to randomly sel
Lipid A (a hexaacylated 1,4' bisphosphate) is a potent immune stimulant for TLR4/MD-2. Upon lipid A ligation, the TLR4/MD-2 complex dimerizes and initiates signal transduction. Historically, studies also suggested the existence of TLR4/MD-2-independent LPS signaling. In this article, we define the role of TLR4 and MD-2 in LPS signaling by using genome-wide expression profiling in TLR4- and MD-2-de
