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Popular Abstract in Swedish Typ 2-diabetiker: söt som socker och rik på fett Det finns flera olika varianter av diabetes och den mest förekommande är typ 2-diabetes (T2D). T2D kallades förr i dagligt tal åldersdiabetes, men numera drabbas individer i alla åldrar. Sjukdomen kännetecknas av förhöjda nivåer av socker och fett i blodet, vilket beror på att kroppens celler har en nedsatt förmåga att tType 2 diabetes (T2D) is a heterogeneous disease characterized by altered lipid parameters and elevated glucose levels, as a direct consequence of impaired insulin signaling in target tissues and reduced insulin exocytosis from pancreatic β-cells. Obesity, which dramatically increases worldwide, is associated with insulin resistance and T2D. In this thesis, we elucidate the effects of hormones and

Allergen-specific immunotherapy (AIT) induces tolerance and shifts the Th2 response towards a regulatory T-cell profile. The underlying mechanisms are not fully understood, but dendritic cells (DC) play a vital role as key regulators of T-cell responses. DCs interact with allergens via Fc receptors (FcRs) and via certain C-type lectin receptors (CLRs), including CD209/DC-SIGN, CD206/MR and Dectin-

We report the signature of an unconventional zwitterion in thick (>40 angstrom) L-cysteine films grown at low temperature (100 K) by means of sublimation in ultrahigh vacuum. Using X-ray photoelectron spectroscopy (XPS) we find that protonated amino groups (57%) are less prevalent than in films grown at higher temperatures. A large majority of the protonated amino groups receive the hydrogen throu

This study explores the influences of steric hindrance and excited state solvent ligation on the excited state dynamics of Cu(I) diimine complexes. Ultrafast excited state dynamics of Cu(I)bis(3,8-di(ethynyltrityl)-1,10-phenanthroline) [Cu(I)(detp)(2)](+) are measured using femtosecond transient absorption spectroscopy. The steady state electronic absorption spectra and measured lifetimes are comp

Denna undersökning studerar vilka säkerhetsperspektiv som speglas i idén Skyldigheten att Skydda genom att utforska ett par nyckeldokument: ICISS rapport från 2001 samt FN:s summitdokument från 2005. Med hjälp av en idé- och ideologianalys svarar undersökningen på vilket av det mänskliga, det politiska, det militära samt ett postkolonialt säkerhetsperspektiv som framförallt speglas i Skyldigheten

Primarily due to a massively overburdened docket, the European Court of Human Rights has been experiencing major challenges in the last decade. The crisis has prompted it to modify its procedures and one recent innovation at the Court is the pilot judgment procedure, which is a tool for dealing with systemic deficiencies in the Member States. This thesis assesses what the effects of the pilot judg

Thought Leadership är en kunskapsbaserad position, som The Big Four vill uppnå hos sina kunder. Målet är att positionera sig, och positionen underbyggs av kunskap internt hos revisionsbolaget. Thought Leadership är ett omfattande arbete, som det skyltas lite med. Kännedomen hos konsumenter är lågt och det är viktigt att ta hänsyn till i arbetet med Thought Leadership, för att nå önskad effekt.

The pressure on businesses to act ethically and to get involved in the development area has increased. At the same time, the strength of sportsas a vehicle for development is highlighted from various worldly respected leaders and organizations. The research maps the emerging field of businesses responsibility, development andsport in Kenya. Fifteen companies, which operate in the Kenyan market, ar

The thesis attempts to assess the role of the OECD Commentaries in tax treaty interpretation process concluded between Non-OECD and OECD states. In order to reach the goal of the thesis the thesis discusses the legal status of the OECD Commentaries under public international law, in particular the interrelation of the Commentaries with the Articles of 31 and 32 of the Vienna Convention. The thesis

The war in Ukraine has rocked the international security order with a changed threat picture as a fact. The relationship between China, Russia and the West is complex due to that China agrees with Russia in a common adversary; Western democratic values, while having economic interests in continuing exporting their goods to the West. The united West, including its sanctions against Russia, can put

Climate change is a global issue and a serious threat to the world we live in. The consequences of climate change are devastating. Despite the overwhelming scientific consensus on climate change, studies have shown that politicians and voters of far-right parties are particularly likely to dismiss climate change. People who in various ways go against the research and large amounts of scientific ev

This paper takes a point of departure in the municipality of Copenhagen (two administrations herein) and their participation in Eurocities. The main question is what kind of processes of Europeanization that takes place in the two administrations. Furthermore, it will be discussed what kind of approach they are taking to European cooperation and how their perception and reflection on the matter is

Under mer än 800 år har en bitter konflikt utkämpats mellan främst Irland och Storbritannien. De senaste 50 åren har denna konflikt primärt handlat om Nordirlands varande eller icke varande i unionen med Storbritannien. Den komplexa historien till trots kunde ett avtal tecknas mellan de inblandade parterna 1998. Denna uppsats fokuserar främst på USA som inbegrips i konflikten i början på 90-talet,

In this essay we discuss the importance of the rule of law for upholding fundamental rights within the liberal democratic state formation. The case in point is that of the Jamaica state and its longstanding record of arbitrary human rights practices. Under the rule of law all parts of the state apparatus is subject to the principals of legality and accountability, this entails testing the legality

In this theses I discuss and analyse how nationalism effects local conflict reporting with a field study in Israel and the occupuied territories. Since 2000 Israelis and Palestinians have not been able to meet each other. The Israelis do not enter the occupied palestinian territories because of fear and Palestinians are not allowed to enter Israel without a special permitt. Instead they met throug

How political order sustains and is constructed is a fundamental problem in the social sciences, and it is still disagreement of how it should be solved. The structure of the operating system is argued has changed, which has contributed to the nation-states ability to manage the problem of political order has enervated. The thesis point of departure is that the traditional way of study and analyze

The aim of this research is to create an understanding for the motivation to include conditional clauses regarding foreign countries in domestic green house gas (GHG) abatement legislation. In addition I aim to explain how these clauses change the strategic environment, in an interaction with the purpose to reach an international environmental agreement (IEA) to combat global warming. I chose this

The purpose of this thesis is to criticize the Commission’s approach to the application of Article 82 to the exclusionary abuses of the dominant firms. It is a very interesting and hot topic as the attitude of the Commission and the European Courts have many implications on the consumer welfare and total efficiency in common market and innovation capacity and the economic development of the Europe

Syftet med uppsatsen är att undersöka hur teorin The Leadership Pipeline kan tillämpas för att förstå chefsflödet i en matrisorganisation. Det kommer därför att ske en prövning om hur väl teorin går att applicera i en matrisorganisation och om den behöver utvecklas för att passa in. Uppsatsen har använt sig av en kvalitativ metod där sju respondenter från fallföretaget Ericsson Mobile Platforms (E