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Few data exist regarding predictors of rapid aortic root dilation and referral for aortic surgery in Marfan syndrome (MFS). To identify independent predictors of the rate of aortic root (AoR) dilation and referral for aortic surgery, we investigated the data from the Pediatric Heart Network randomized trial of atenolol versus losartan in young patients with MFS. Data were analyzed from the echocar

BACKGROUND: Locally advanced breast carcinoma is associated with a poor prognosis. With single treatment modalities, i.e., surgery and/or radiation therapy, results have been consistently dismal. However, several earlier reports have indicated improvement in survival with a combined modality approach, i.e., the utilization of systemic therapy.METHODS: Between 1991 and 1994, 128 patients with local

Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient availability of biomarkers represents a significant gap in understanding the disease cause and progression. We conduct blinded, two-phase case-control plasma proteomics on the TEDDY study to identify biomarkers predictive of T1D development. Untargeted proteomics of 2,252 samples from 184 individuals identify 376 re

Genome-wide association studies (GWASs) identified hundreds of signals associated with type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have created the translational human pancreatic islet genotype tissue-expression resource (TIGER), aggregating >500 human islet genomic datasets from five cohorts in the Horizon 2020 consortium T2DSystems. We impute genotypes u

Genom äktenskapsförord har makar möjlighet att reglera sina egendomsförhållanden vid en eventuell skilsmässa. Om en make anser att ett eller flera villkor i äktenskapsförordet är oskäliga kan denne åberopa jämkning enligt bestämmelsen i 12 kap. 3 § Äktenskapsbalken (SFS 1987:230) (ÄktB). I förarbetena till lagen, prop.1986/87:1, uttalade departementschefen att bestämmelsen ska tillämpas restriktivThrough prenuptial agreements, spouses have the opportunity to regulate their economic conditions in case of a divorce. If one spouse finds one or more conditions in the agreement to be unreasonable, they can appeal for adjustment of this through the regulation in 12 ch. 3 § ÄktB (the Swedish martial law). In the legislative history of the law, prop.1986/87:1, the minister expressed that the admin

This thesis examines two central questions concerning business transfers under Swedish and EU labour law: (1) which collective agreement, and which parts of it, become binding for the transferee when a business, undertaking, or part thereof is transferred in accordance with Section 6 b of the Swedish Employment Protection Act (LAS); and (2) what role the collective agreement plays in determining w