Search results

The shore protection has in Sweden been statutory regulated since 1950. Since then it has been extended and developed, as the awareness of the importance for preservation of unexploited land along the shores has grown. The earlier legislation focused entirely on human’s access to the shores and the surroundings near the shores, for recreation and extracurricular activities. The terms for, and presThe shore protection has in Sweden been statutory regulated since 1950. Since then it has been extended and developed, as the awareness of the importance for preservation of unexploited land along the shores has grown. The earlier legislation focused entirely on human’s access to the shores and the surroundings near the shores, for recreation and extracurricular activities. The terms for, and pres

The recent Kunming-Montreal Global Biodiversity Framework (GBF) sets ambitious goals but no clear pathway for how zero loss of important biodiversity areas and halting human-induced extinction of threatened species will be achieved. We assembled a multi-taxa tracking dataset (11 million geopositions from 15,845 tracked individuals across 121 species) to provide a global assessment of space use of

Alkaliskt sfingomyelinas, en antiinflammatorisk faktor som kan motverka colit och colorektal cancer Rui-Dong Duan, Erik Hertervig, Åke NilssonBakgrund: Borstbrämsenzymet alkaliskt sfingomyelinas (alk-SMas) som vi upptäckt, renat och klonat hydrolyserar sfingomyelin (SM) och den proinflammatoriska glycerofosfolipiden platelet activating factor (PAF). Metaboliter av SM är anticarcinogena och inaktiv

Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls. We identify a novel association of a low-frequency nonsynonymous SNV in GLP1R (A316T; rs10305492; MAF=1.4%) with lower FG (β=-0.09±0.01

Genome-wide association studies (GWAS) have provided strong evidence for inherited predisposition to childhood acute lymphoblastic leukaemia (ALL) identifying a number of risk loci. We have previously shown common SNPs at 9p21.3 influence ALL risk. These SNP associations are generally not themselves candidates for causality, but simply act as markers for functional variants. By means of imputation

Popular Abstract in Swedish Nya möjligheter att förutsäga sjukdomsutvecklingen vid tidig ledgångsreumatism. I denna avhandling presenteras resultaten från sex studier av patienter med tidig reumatoid artrit (RA) – ledgångsreumatism. Syftet med avhandlingen var att i det tidiga sjukdomsskedet, så snart som möjligt efter diagnos, försöka skaffa information om hur sjukdomen kommer att utvecklas - om Objective: To investigate the role of magnetic resonance imaging (MRI), assessment of bone mineral density (BMD) and antibodies to citrullinated proteins (anti-CCP) in predicting radiologic outcome in patients with early rheumatoid arthritis (RA). Patients: All patients were included in the BARFOT programme (baseline). The patients had rheumatoid arthritis of recent onset with mean disease duratio

Popular Abstract in Swedish Människans arvsmassa består av DNA. DNA i sin tur består av nukleotiderna A, T, G och C som i olika kombinationer bygger upp våra gener. Människans "genom" (hela arvsmassa) består av uppåt 100 000 gener och varje gen kodar för ett protein som i sin tur är byggstenarna i våra kroppar. Eftersom DNA är en oerhört lång molekyl och cellerna är väldigt små (ca 10 micrometer) Chromosomal translocations commonly result in the production of fusion genes and the fusion genes are often tumor-type specific. In myxoid and round cell liposarcomas (MLS/RCLS), almost 95% of the cases carry a t(12;16)(q13;p11). In the remaining 5% of the MLS/RCLS tumors, another translocation and fusion gene can be found, i.e. the t(12;22)(q13;q12). These translocations fuse CHOP on chromosome 1

AIMS/HYPOTHESIS: Evidence that glucose-dependent insulinotropic peptide (GIP) and/or the GIP receptor (GIPR) are involved in cardiovascular biology is emerging. We hypothesised that GIP has untoward effects on cardiovascular biology, in contrast to glucagon-like peptide 1 (GLP-1), and therefore investigated the effects of GIP and GLP-1 concentrations on cardiovascular disease (CVD) and mortality r