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Background: Hemophilia A patients with inhibitors are generally treated with preparations containing activated coagulation factors to achieve hemostasis by bypassing factor (F)VIII. Objectives: We developed an assay for monitoring the kinetic of thrombin generation in human FVIII inhibitor plasma reconstituted in vitro with activated prothrombin complex concentrate, FEIBA, and in plasma samples fr
We report the experimental observation of a strongly selective population of the spin-orbit components in the HCl+ (X) over tilde (2)Pi(Omega) states after excitation into the dissociative 2p(-1)6sigma* core excited state. A progression of highly excited vibrational states with either the Omega=3/2 or Omega=1/2 component of the final state is populated, respectively, when the excitation is tuned i
Sixty-five patients who were primary or secondary refractory to melphalan/prednisone or other type of chemotherapy, or relapsed within 6 months after high dose chemotherapy with stem cell support, were given thalidomide at a dose of 200 mg/d escalating to 800 mg. The patients were followed for a median of 2 years and 22 weeks. Response was evaluated according to M-protein reduction combined with i
The glycaemic index (GI) concept is based on the difference in blood glucose response after ingestion of the same amount of carbohydrates from different foods, and possible implications of these differences for health, performance and well-being. GI is defined as the incremental blood glucose area (0-2 h) following ingestion of 50 g of available carbohydrates in the test product as a percentage of
Postadress Box 117, 221 00 Lund · Besöksadress Allhelgona kyrkogata14 M · Telefon 046-222 0801 · Fax 046-222 4004 E-post studievagledare@genus.lu.se · Webbadress www.genus.lu.se Genus vetenskap l i ga i ns t i tu t ionen Arbetsmiljöarbete vid Genusvetenskapliga institutionen perioden 2015-2017 Antagen av Genusvetenskapliga institutionens styrelse 2014-11-12 Det yttersta ansvaret för arbetsmiljöarb
https://www.genus.lu.se/sites/genus.lu.se/files/arbetsmiljoplan.pdf - 2026-05-28
Antalet höstrastande och övervintrande gäss i Sverige 2023/2024. Staging and wintering geese in Sweden 2023/2024 Fredrik Haas Lunds universitet Haas, F. 2025. Antalet höstrastande och övervintrande gäss i Sverige 2023/2024. Biologiska institutionen, Lunds universitet. Haas, F. 2025. Staging and wintering geese in Sweden 2023/2024. Department of Biology, Lund university. Foton: Åke Lindström 2 Inne
Till de absolut mest fascinerande problemen inom matematiken hör de som är enkla att formulera och förstå sig på men som trots detta stått emot sofistikerade attacker under en längre tid. Collatz förmodan eller ”3n+1-problemet”, vilket det kanske är mer känt som, hör till denna kategori. I snart hundra år har matematiker – bland dessa, några av vår tids främsta – utan framgång angripit det. Vad ärWe investigate the dynamics of the Collatz map over various domains. In particular, cycles will be studied, and conditions for their existence will be provided.
Alternative macrophage activation is implicated in diverse disease pathologies such as asthma, organ fibrosis, and granulomatous diseases, but the mechanisms underlying macrophage programming are not fully understood. Galectin-3 is a carbohydrate-binding lectin present on macrophages. We show that disruption of the galectin-3 gene in 129sv mice specifically restrains IL-4/IL-13-induced alternative
Popular Abstract in Swedish Något som kan låta motsägelsefullt är att en stjärna fungerar som en svartkropp. Med svartkropp menas ett objekt, vilkens energiförlust i form av elektromagnetisk strålning bestäms av föremålets temperatur och storlek. Våglängderna på strålningen som lämnar ett objekt bestäms däremot endast av temperaturen. En snöboll med temperaturen -10 C strålar 271 W m$^{-2}$ medanThe spectra of symbiotic stars are shown to frequently contain numerous fluorescence lines caused by Photo-excitation by Accidental Resonance (PAR). So far, most work involving fluorescence in stellar spectra has been assigned to the search of new PAR mechanisms, which can explain the presence of certain emission lines. This is taken a step further as the PAR pumped emission lines are analyzed to
Popular Abstract in Swedish Populärvetenskaplig sammanfattning på svenska Datortolkning av myokardscintigrafibilder Kärlkramp och hjärtinfarkt sammanfattas ibland under benämningen ischemisk hjärtsjukdom, en vanligt förekommande sjukdom i många industriländer. Sjukdomen beror främst på förträngningar i hjärtats kranskärl, dvs. de kärl som förser hjärtmuskulaturen med blod. Sjukdomen går att behaIn the studies of this thesis, a method for automated classification of myocardial perfusion images was successfully developed and evaluated. The results show that the method, based on artificial neural networks, was equally good, or even better than human experts. It was also found that physicians interpreting myocardial perfusion images benefit from the advice of the artificial neural networks.
Phosphodiesterase 3B (PDE3B) is an important component of insulin and cAMP-dependent signalling pathways. In order to study phosphorylation of PDE3B, we have used an adenoviral system to express recombinant flag-tagged PDE3B in primary rat adipocytes and H4IIE hepatoma cells. Phosphorylation of PDE3B after treatment of cells with insulin, cAMP-increasing agents, or the phosphatase inhibitor, calyc
In order to identify biological processes relevant for cell death and survival in the brain following stroke, the postischemic brain transcriptome was studied by a large-scale cDNA array analysis of three peri-infarct brain regions at eight time points during the first 24 h of reperfusion following middle cerebral artery occlusion in the rat. K-means cluster analysis revealed two distinct biphasic
Objectives To determine the accuracy of established ultrasound dating formulae when used at 12-14 weeks of gestation. Methods One-hundred and sixty-seven singleton pregnancies conceived after in-vitro fertilization (IVF) underwent a dating scan at 12-14 weeks of gestation. Gestational age at the dating scan was calculated by adding 14 days to the number of days between the date of oocyte retrieva
The electronic structure of the strongly Coulomb correlated cuprate CuGeO3 has been calculated by the local-density-approximation method (LDA+U). The parameter U was varied from 0 to 8 eV. The results of the band-structure calculations are compared with experimental data obtained by means of X-ray photoelectron and resonant X-ray emission spectroscopy methods (Cu Lalpha and O Kalpha X-ray emission
Previous studies have identified an association between osteoporotic fracture and a polymorphism affecting a Sp1 binding site in the first intron of the collagen type I alpha 1 gene (COL1A1). It is currently unclear, however, whether this association is direct or the result of linkage disequilibrium with other polymorphisms situated nearby. In this study we analyzed the relationship between four w
Nerve growth factor (NGF) protein levels were determined in various forebrain regions using a two-site immunoassay following kindling-induced seizures. In the dentate gyrus the NGF content was significantly elevated 7 days after the last seizure (to 152% of control). In the piriform and parietal cortices, maximal increases were seen at 12 h (to 261% of control) and at 24 h (to 169% of control), re
Popular Abstract in Swedish Kliniska aspekter på ärftlig bröstcancer, en populärvetenskaplig sammanfattning på svenska Bröstcancer är den vanligaste cancerformen hos kvinnor. Ungefär 10% av kvinnorna i den svenska befolkningen får någon gång under livet denna sjukdom. Förekomst av sjukdomen i familjen är en av de starkaste riskfaktorerna för att en kvinna ska utveckla bröstcancer, och i 5-10% av A positive family history of breast cancer (BC) is one of the strongest predictors of the disease. Two major BC susceptibility genes, BRCA1 and BRCA2 were identified about a decade ago. In this thesis, studies of different biological. clinical and epidemiological aspects of hereditary BC are presented. In the first paper data on the expression of steroid hormone receptors in hereditary BC are pres
