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Under anaerobic conditions S. cerevisiae produces glycerol to regenerate NAD+ from the excess NADH produced in cell metabolism. We here report on the role of an uncharacterized protein, Yig1p (YpI201cp), in anaerobic glycerol production. Yig1p was previously shown to interact in two-hybrid tests with the GPP1 and GPP2 encoded glycerol 3-phosphatase (Gpp), and we here demonstrate that strains overe
The aim of this study was to collect new knowledge about the importance of signal crayfish predation on zebra mussels in Lake Erken. Possibly with implications on biological control of the invasive species in Swedish lakes. I performed a field experiment with enclosures (including signal crayfish) and exclosures (without signal crayfish) during 11 summer weeks in Lake Erken. My results showed that
Estimating the spatial extent of the impacts of renewable energy infrastructure on tourism is crucial for the identification of potential locations of resource use conflict. Such a task, however, is complicated and requires inclusion of social perceptions on the spatial extent of the impacts. This study investigates perceptions of the tourism industry in Iceland regarding the impact area of existi
Accurate communication of the severity of violence in intimate relations is essential for the appropriate evaluation of offenders and victims in contexts such as court trials, custody cases, and the continuation of relationships. Using a new paradigm, this study quantifies discrepancies in how the severity of violence is communicated in texts written by offenders, victims, and bystanders who witne
There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). The severity of the coronavirus disease 2019 (COVID-19) is inversely correlated with HDL plasma levels. It is known that the SARS-CoV-2 spike (S) protein binds the HDL particle, probably depleting it of lipids and altering HDL function. Based on neutron reflectometry (NR) and
Facilitated by mobility, occupational participation outside the home is vital in old age. However, the relative importance of factors influencing mobility and occupational participation remains unclear. The present study describes older peoples’ motives for, and experiences of, mobility and occupational participation outside the home. Nine focus-group interviews were conducted and analyzed using c
The Gram-positive bacterium Streptococcus pneumoniae is a major human pathogen that causes infections ranging from acute otitis media to life-threatening invasive disease. Pneumococci have evolved several strategies to circumvent the host immune response, in particular the complement attack. The pneumococcal glycolytic enzyme phosphoglycerate kinase (PGK) is both secreted and bound to the bacteria
Background: Arterial hemodynamic parameters derived from reservoir-excess pressure analysis exhibit prognostic utility. Reservoir-excess pressure analysis may provide useful information about an influence of altered hemodynamics on target organ such as the kidneys. We determined whether the parameters derived from the reservoir-excess pressure analysis were associated with the reduction in estimat
Background: The menopause transition is associated with unfavourable alterations in health. However, postprandial metabolic changes and their mediating factors are poorly understood. Methods: The PREDICT 1 UK cohort (n=1002; pre- n=366, peri- n=55, and post-menopausal females n=206) assessed phenotypic characteristics, anthropometric, diet and gut microbiome data, and fasting and postprandial (0–6
Protein C is a vitamin K-dependent protein circulating in plasma as a zymogen to an anticoagulant serine protease. After its activation, protein C cleaves and inactivates coagulation factors Va and VIIIa. Human protein C is synthesized in liver and undergoes extensive post-translational modification during its synthesis. Recently, the protein C inhibitor was demonstrated to be synthesized in sever
BACKGROUND: Forefoot gangrene in patients with diabetes is a severe form of foot ulcers with risk of progress and major amputation. No large cohort studies have examined clinical characteristics and outcome of forefoot gangrene in patients with diabetes. The aim was to examine clinical characteristics and outcome of forefoot gangrene in patients with diabetes admitted to a diabetic foot centre.MET
How actors relate to the future has long been considered important in research on the governance of transformations towards sustainability. Recent contributions have explored the politics at play in the ‘making’ of futures and the forming of collective expectations. Building on the concept of socio-material incumbency and integrating academic discussions which appreciate the politics of future-mak
Diverse perspectives are essential to the advancement of biodiversity science, yet persistent structural biases continue to shape who is seen and heard in academic spaces. Despite efforts to promote inclusivity, it remains unclear whether increased representation translates into equitable visibility and engagement from peers. Seminar talks, key arenas for idea exchange and networking, offer a wind
Aims With a growing population of women with congenital heart disease (CHD), pregnancies in this group are expected to increase. However, pregnancy in women with CHD is associated with increased adverse outcomes for both mother and child. The aim of this study was to evaluate pregnancy and foetal complications in women with CHD and to test their association with the modified WHO (mWHO) classificat
Purpose – Our research examines the impact of Islamic religiosity, exploring the role of religious actors, religious ideas (knowledge-based religiosity) and religious practice, on the involvement in early-stage entrepreneurial activity at the provincial level in Indonesia. Design/methodology/approach – We rely on the survey conducted by Global Entrepreneurship Monitoring in Indonesia, spanning fro
In this chapter, I describe how technological progress triggers and shapes structural change within the economy and society, which in turn—if the resulting changes are significant enough—may shift the scope and outcome of established legislation and regulatory frameworks. The argument presented focuses on the ongoing digitalization, using its common technological characteristics to identify and de
