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Two different main concepts for the treatment of a severe traumatic brain injury have been established during the last 15 years, namely the more conventional concept recommended in well-established guidelines (eg, U.S. Guideline, European Guideline, Addelbrook's Guideline from Cambridge), on the one hand, and the Lund concept from the University Hospital of Lund, Sweden, on the other. Owing to the

The interregional traveller’s preferences of railway stations, their service provision and location, are of interest in the discussion of station reinvention brought on by the introduction of high speed train traffic. A railway station is created by station as well as societal agents, and can be described as a synthesis of symbolic value, location, traffic, services and stationscape. Traveller pr

This paper addresses the need for secure storage in virtualized services in the cloud. To this purpose, we evaluate the security properties of Intel's Software Guard Extensions (SGX) technology, which provides hardware protection for general applications, for securing virtual Hardware Security Modules (vHSM). In order for the analysis to be comparable with analyses of physical HSMs, the evaluation

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The Potchefstroom Fire Protection Association (FPA) has an important role in preventing and managing veld fires in the Tlokwe Local Municipality’s rural environment. The FPA works closely with several governmental stakeholders, but these stakeholders do not view the FPA as having high levels of organisational legitimacy. A lack of organisational legitimacy hinders the FPA in obtaining its organisa

Background: Since the publication of the European League Against Rheumatism (EULAR) recommendations for the management of large vessel vasculitis (LVV) in 2009, several relevant randomised clinical trials and cohort analyses have been published, which have the potential to change clinical care and therefore supporting the need to update the original recommendations. Methods: Using EULAR standardis

A search for the production of three massive vector bosons in proton–proton collisions is performed using data at s=13 TeV recorded with the ATLAS detector at the Large Hadron Collider in the years 2015–2017, corresponding to an integrated luminosity of 79.8 fb−1. Events with two same-sign leptons ℓ (electrons or muons) and at least two reconstructed jets are selected to search for WWW→ℓνℓνqq. Eve

Background: The Movement Disorder Society criteria for progressive supranuclear palsy introduced the category “probable 4-repeat (4R)-tauopathy” for joint clinical diagnosis of progressive supranuclear palsy and corticobasal degeneration. Objectives: To validate the accuracy of these clinical criteria for “probable 4R-tauopathy” to predict underlying 4R-tauopathy pathology. Methods: Diagnostic acc

Cross-sectional studies of growth in post-colonial Africa have overwhelmingly focussed on explaining the failure of growth in Africa. This prompting stylised fact has its qualifications and when these are taken into consideration the explanations of African economic growth appear incoherent. The notion of a chronic African growth failure has diverted attention from the process of economic growth a

Secondary metabolites from fungi have become a major source of chemical innovation in programs searching for lead molecules with bioactivities, especially over the last 50 years. In this review, we discuss the fundamental considerations in the discovery of molecules for agricultural and medicinal uses. This group of organisms possesses a strong potential for scientific and industrial communities.

We can trace the beginnings of our knowledge of early Upper Paleolithic (Aurignacian) use of fire to the pioneering 1910–1911 excavations at Abri Blanchard undertaken by Louis Didon and Marcel Castanet. At Blanchard, the excavators recognized and described fire structures that correspond in many ways to features excavated more recently in Western and Central Europe. Here, we address the issue of h

The Just-in-Time production system, or lean production system, tries to achieve a continuous flow of production, thereby reducing the inventories of materials, works-in- process and finished products. As a result only minimum levels of inventories exist in the various layers of the supply chain. Under this situation, the major earthquake followed by the tsunami on March 11, 2011 in Eastern Japan,

After many years of preclinical development, cell and gene therapies have advanced from research tools in the lab to clinical-grade products for patients, and today they constitute more than a quarter of all new Phase I clinical trials for Parkinson's disease. Whereas efficacy has been convincingly proven for many of these products in preclinical models, the field is now entering a new phase where