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Recent observations of the gamma-ray source HAWC J2227+610 by Tibet AS+MD and LHAASO confirm the special interest of this source as a galactic PeVatron candidate in the northern hemisphere. HAWC J2227+610 emits Very High Energy (VHE) gamma-rays up to 500 TeV, from a region coincident with molecular clouds and significantly displaced from the nearby pulsar J2229+6114. Even if this morphology favour

This thesis is a study of social life, addressing issues concerning how and by what means people meet in urban public space. The main aim of this thesis is to is to investigate how certain artefacts and architectural features support the formation and temporal stabilisation of heterogeneous clusters and collectives, and thus, in order to the development of conceptual tools that can contribute to a

Pulmonary diseases are known to be largely inhomogeneous. To evaluate such inhomogeneities, we are testing an image-based method to measure gas flow in the lung regionally. Dynamic, spin-density-weighted hyperpolarized (3)He MR images performed during slow inhalation of this gas were analyzed to quantify regional inflation rate. This parameter was measured in regions of interest (ROIs) that were d

p90 ribosomal S6 kinases (RSKs) respond to various mitogen stimuli and comprise two distinct protein kinase domains. The C-terminal kinase domain (CTKD) receives signal from ERK1/2 and adopts an autoinhibitory mechanism. Here, the crystal structure of human RSK1 CTKD is reported at 2.7 Å resolution. The structure shows a standard kinase fold, with the catalytic residues in the ATP-binding cleft or

In this paper the Poisson bracket algebra for the open massless relativistic string in the one-space-and one-time-dimensional case is considered. In order to characterize the orbit of the system the directrix function, i.e., the orbit of one of the endpoints of the string, is used. It turns out that the Poisson bracket algebra is of a very simple form in terms of the parameters of the directrix fu

This article analyses the nexus of technocracy-peacebuilding and its implications on water conflicts and hydropolitics. It is a conceptual exploration, which advances an interdisciplinary approach by combining theories from two distinct research fields: peacebuilding and transboundary water management. It probes the argument that synergies between water management, development and peacebuilding fr

There is growing awareness that the profound changes in the environment (eg, in diet and other lifestyle conditions) that began with the introduction of agriculture and animal husbandry approximate to10 000 y ago occurred too recently on an evolutionary time scale for the human genome to adjust. In conjunction with this discordance between our ancient, genetically determined biology and the nutrit

BACKGROUND: Patients with inflammatory joint diseases tend due to new treatments to be more physically active; something not taken into account by currently used outcome measures. The Rheumatoid and Arthritis Outcome Score (RAOS) is an adaptation of the Knee injury and Osteoarthritis Outcome Score (KOOS) and evaluates functional limitations of importance to physically active people with inflammato

Analytic expression for the exact bit error probability of the (7,5) convolutional code was discussed. Recursive systematic encodes which became especially important as component encoders in concatenated coding schemes were also studied. This technique can calculate the probability distribution of the output log-likelihood ratios of the Max-Log-MAP algorithm in analytic form.

Visual abilities of the honey bee have been studied for more than 100 years, recently revealing unexpectedly sophisticated cognitive skills rivalling those of vertebrates. However, the physiological limits of the honey bee eye have been largely unaddressed and only studied in an unnatural, dark state. Using a bright display and intracellular recordings, we here systematically investigated the angu

This chapter is a micro-sociological exploration of the justifications that Danish general practitioners adopt to support antibiotic usage in their clinical practices. Based on qualitative in-depth interviews with 21 general practitioners in Denmark, the chapter looks upon the clinic as a particular social world (a justificatory regime) in which different antibiotic treatment strategies are qualif

Automated task planning for robots is usually implemented on a motion primitive domain, where the focus is on constructing meaningful, general motion primitives. In this work we propose planning on the higher abstraction level of robot skills. In this context, skills are general, functional blocks that contain both sensing and action, have a welldefined expected outcome and set of preconditions, a

The article describes a new method for determining the biological age (BV) of a person, developed by a team of authors: A. Skrebneva, V. Popov, A. Buslova. The goal and objectives are to develop a new method for assessing BV with determining its validity and usefulness for predicting the rate of aging in the framework of a large national sample of people. Material and methods. For the work, anonym