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Significance Our results demonstrate the existence of early cellular pathways and network alterations in oligodendrocytes in the alpha-synucleinopathies Parkinson's disease and multiple system atrophy. They further reveal the involvement of an immune component triggered by alpha-synuclein protein, as well as a connection between (epi)genetic changes and immune reactivity in multiple system atrophy

The lack of treatments during the recent Ebola and Zika outbreaks dramatically exposed the vulnerability of the global health system and the dire consequences thereof. But even where therapies against infectious diseases had been available, an additional threat has gained world-wide attention: antimicrobial resistance (AMR). A growing number of microbial organisms are becoming resistant to availab

Background Coronary artery disease is the primary etiology for sudden cardiac arrest in adults, but potential differences in the incidence and utility of invasive coronary testing between resuscitated men and women have not been extensively evaluated. Our aim was to characterize angiographic similarities and differences between men and women after cardiac arrest. Methods and Results Data from the

OBJECTIVE: Although hospitals have been described as inadequate place for end-of-life care, many deaths still occur in hospital settings. Although patient-reported outcome measures have shown positive effects for patients in need of palliative care, little is known about how to implement them. We aimed to explore the feasibility of a pilot version of an implementation strategy for the Integrated P

ObjectiveImplementation of patient-reported outcome measures for patients with palliative care needs is characterized by both enablers and barriers. The ways in which healthcare professionals experience the use of assessment tools is important. Our aims were to explore factors contributing to or hindering patients with palliative care needs in assessing their symptoms with the Integrated Palliativ

Objectives:The Multidimensional Dyspnea Profile (MDP) comprehensively addresses dyspnea, incorporating both perceptual and affective components, and has proven effective in assessing breathlessness among patients with chronic lung conditions. Despite its validation in High-Income Countries, its applicability in Low/Middle-Income countries remains uncertain. Additionally, the MDP has not been trans

Healthcare organizations are under increasing pressure to account for their performance to outside constituencies. This chapter reviews the background, nature, and consequences of organized efforts to enhance transparency in healthcare. The driving forces differ between regions, but the trends are broad enough to result in similar developments across Europe. Market reforms and quality concerns cre

Background: Chronic breathlessness adversely impacts people with chronic obstructive pulmonary disease and their caregivers (family and friends), who may, in turn, experience significant burden due to their caregiving role. Sustained-release morphine may reduce chronic breathlessness in some patients, which may have an impact on caregivers’ perceived burden. Aim: To explore the impact on caregiver

Acute myeloid leukemia (AML) is characterized by a differentiation block leading to accumulation of immature cells. Chromosomal translocations in AML affect transcription factors that are involved in regulation of myeloid differentiation. Aberrant expression of these factors interferes with differentiation events and has a role in the pathogenesis of AML through superactivation or (dominant negati

Rationale: According to the Global Initiative for Obstructive Lung Disease (GOLD), the FEV1/FVC ratio is used to confirm the presence of airflow obstruction in the diagnosis of chronic obstructive pulmonary disease (COPD), whereas FEV1 percent predicted normal value (FEV1%pred) is used for grading its severity. The STaging of Airflow obstruction by the FEV1/FVC Ratio (STAR), and its prediction of

Background: Family members play a crucial role in supporting women with breast cancer during their recovery. In the complex situation of being an informal caregiver, their own health and ability to support the patient needs to be acknowledged. The aim was to explore the experiences, needs and roles of family members throughout the rehabilitation process of women with breast cancer. Methods: A qual

Objectives: Dyspnea, or breathlessness, is a frequent and distressing symptom among patients with heart and lung diseases, particularly in advanced cancer stages, where it affects up to 90% of lung cancer cases. This symptom considerably diminishes quality of life, leading to physical deconditioning, increased levels of anxiety and depression, repeated hospitalizations, and elevated mortality rate

Background In adults with serious respiratory illness, breathlessness is prevalent and associated with reduced health-related quality of life. The aim of this review was to assess the impact of breathing techniques on breathlessness in adults with serious respiratory illness. Methods Electronic databases were searched to identify randomised controlled trials testing breathing techniques (technique

Background: Percutaneous coronary intervention (PCI) of saphenous vein grafts (SVG) is associated with poor outcomes and is often regarded as inferior to native vessel PCI. We investigated clinical outcomes of SVG-PCI using contemporary drug-eluting stents (DES), in a complete, nationwide population. Methods: The complete Swedish Coronary Angiography and Angioplasty Registry (SCAAR) was used to id

In 1778, a large bronze bell was cast by royal bellfounder Michael Troschell in Copenhagen. Unlike most of his bells, which were destined for church towers, this one was sent to La Grange, the largest plantation on St. Croix in the Danish West Indies. The bell functioned as an instrument of discipline, structuring the workday for more than a thousand enslaved laborers. This paper explores the plan

Tonkilometermetoden används för beräkning av andelstal för enskilda vägar som är gemensamhetsanläggningar. Den trafikmängd som olika fastighetstyper genererar återspeglas i vissa framtagna schablonvärden. Eftersom det saknas framtagna schablonvärden för specialfastigheter såsom vindkraftverk och vattenkraftverk har jag genom detta examensarbete undersökt möjligheten att ta fram schablonvärden för The ton kilometer method is used to calculate participatory shares for private roads which is joint facility. The amount of traffic that different property types generate is reflected in certain produced templates. Because there are no templates for special properties such as wind turbines and hydroelectric plants I have investigated if it is possible to produce these types of values. I have also

Purpose of the study – The purpose of the study is to develop a conceptual framework and model for further research, of front-line logistic workers ́ perception of sharing their personal information at their work. Furthermore, the study aims to create a framework for how to study information disclosure programs potential impact on employee turnover when being implemented on intermediate parties, n

Behandling av personuppgifter på utbildningsområdet 1 Regeringens proposition 2017/18:218 Behandling av personuppgifter på utbildningsområdet Prop. 2017/18:218 Regeringen överlämnar denna proposition till riksdagen. Stockholm den 5 april 2018 Stefan Löfven Gustav Fridolin (Utbildningsdepartementet) Propositionens huvudsakliga innehåll Propositionen innehåller förslag till lagändringar på utbildnin

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/prop_201718_218.pdf - 2026-05-17